Buy 4F-MPH 25mg Pellets Online – (4′‑Fluoromethylphenidate) – 25 mg Pellet (Analytical Reference Material)
Buy 4F-MPH 25mg pellets, or 4‑fluoro‑methylphenidate, is a fluorinated derivative of methylphenidate investigated in synaptic transporter assays, chemical toxicology, and structure–activity relationship (SAR) modeling.
The 25 mg pellet configuration enables mass‑controlled analytical use — e.g., for HPLC/LC‑MS calibration, standardization of controlled‑substance assays, and toxicological detection protocol development in legally licensed laboratories.
Organic / Inorganic Chemistry
| Property | Details |
|---|---|
| IUPAC Name | Methyl 2‑(4‑fluorophenyl)‑2‑(piperidin‑2‑yl)acetate |
| Chemical Formula | C₁₄H₁₈FNO₂ |
| Molecular Weight | 251.30 g · mol⁻¹ |
| Functional Groups | Ester (C=O–O–CH₃), tertiary amine (piperidine), para‑fluoro‑aryl ring |
| Bond types | C–F (aryl), C–N (amine), C–O (ester) |
| Melting point | ≈ 190 °C (HCl salt) |
| Solubility | Soluble in ethanol and methanol; sparingly in water. |
| Stability | Stable in neutral conditions; hydrolyses in base or moisture. |
Chemical Biology
- Class: Phenethylamine/piperidine‑type dopamine reuptake inhibitor.
- Activity: Selective for dopamine (DAT) and norepinephrine (NET) transporters; limited serotonin interaction.
- In‑vitro affinity: Ki(DAT) ≈ 35 nM; ~3× stronger than methylphenidate.
- Applications: Used as a comparative standard for halogen‑substituted stimulant analogues in forensic toxicology.
- Metabolic pathway: Ester hydrolysis to 4‑fluoro‑ritalinic acid; further oxidation by CYP2D6 enzymes.
- Hazards: Neurostimulant; may cause dopamine surge in vivo — research handle only.
Computational Chemistry
| Parameter | Prediction (B3LYP/6‑31G*) |
|---|---|
| Dipole Moment | 2.8 Debye |
| HOMO–LUMO Gap | 5.25 eV |
| Predicted log P | 2.1 – 2.3 |
| pKa (amine) | 8.6 |
| TPSA | 38 Ų |
| Rotatable bonds | 4 |
| Docking energy (hDAT) | ≈ –9 kcal · mol⁻¹ |
| Notes: Fluorination enhances binding affinity through π‑electron distribution and dipole‑π interactions. |
Environmental Chemistry
- Hydrolysis: Slow neutral decomposition; accelerated under alkaline conditions.
- Photodegradation: Moderate UV sensitivity; forms 4‑fluorophenol and piperidine residues.
- Biodegradability: Limited; persistent in organic soil matrices.
- Bioaccumulation: Moderate potential (log Kow ≈ 2.1).
- Disposal: Via hazardous organic waste stream — licensed incineration > 1100 °C.
- Environmental risk: Persistent organic micro‑contaminant if improperly discarded.
Laboratory Equipment
| Instrumentation | Purpose |
|---|---|
| LC‑MS/MS | [M+H]⁺ = 252.134 m/z, key fragments = 84 and 234. |
| GC‑MS (EI) | M⁺ = 251; base peak at 84 (piperidinium cation). |
| FTIR | 1730 cm⁻¹ (C=O), 1240 cm⁻¹ C–O, 1105 cm⁻¹ C–F. |
| ¹H NMR (500 MHz) | δ 7.2 (Ar H), 4.1 (CH near ester), 3.6 (OCH₃), 2.3 (piperidine). |
| Weighing Precision | Microbalance ± 0.1 mg for pellet standardization. |
| Storage Conditions | Dark, dry, ≤ –20 °C, sealed in controlled substance vault. |
Consumables
- LC‑MS grade methanol / acetonitrile / formic acid.
- PTFE syringe filters (0.22 µm), amber HPLC vials.
- Certified pipette sets, microsyringes, and analytical weigh boats.
- PPE: nitrile gloves, lab coat, eye protection, fume hood use.
- Analytical grade water (≥ 18 MΩ cm).
Regulation & Safety
| Aspect | Specification |
|---|---|
| Legal Status | Schedule I (USA Analogue Act); Class B (UK Psychoactive Substance Act 2016); controlled in EU/CA/AU jurisdictions. |
| Permitted Use | Analytical and toxicological testing under licence only. |
| GHS Codes | H301 – Toxic if swallowed ; H331 – Toxic if inhaled ; H370 – Causes organ damage. |
| Hazard Pictograms | ☠️ ⚠️ 🌡️ |
| Safe Handling | Conduct all work in fume hood; wear PPE; seal container post‑use. |
| Spill Measure | Neutralize with activated charcoal, use lined hazardous waste bin. |
| Waste Disposal | Authorized hazard waste contractor — thermal destruction. |
| Emergency Symptoms | Tachycardia, hyper‑alertness, hypertension (if accidental exposure). |
Chemical Informatics
| Identifier | Value |
|---|---|
| SMILES | COC(=O)C(C1CCCCN1)C2=CC=C(F)C=C2 |
| InChIKey | VIGXNXDNAOHARM‑UHFFFAOYSA‑N |
| CAS ID | 1354631‑73‑0 |
| TPSA | 38 Ų |
| Rotatable Bonds | 4 |
| log P | 2.05 (estimated) |
| Use Domain | Forensic libraries · QSAR datasets · controlled‑substance screening algorithms. |
Ethical & Legal Notice
⚠️ Controlled Substance Research Disclaimer
4F‑MPH is classified as a controlled stimulant‑type substance.
Possession, manufacture, or distribution without appropriate authority is illegal.
The data here serve solely scientific, regulatory, and educational purposes in licensed environments.
No statements here constitute medical advice, sales claims, or promotion.
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