Buy 1P-LSD 20mcg Micro Blotters Online
1‑Propionyl‑lysergic acid diethylamide (Buy 1P-LSD 20mcg Micro Blotters) is a propionyl‑substituted lysergamide—a structural analogue of LSD with a propionyl group at the indole nitrogen (N¹).
It is recognized as a lysergamide prodrug, because in vivo or in acidic conditions, the propionyl group cleaves, forming LSD.
The 20 µg micro‑blotter form enables forensic calibration, trace detection testing, and photodegradation research involving lysergamide materials embedded in blotter paper matrices.
Organic / Inorganic Chemistry
| Property | Value |
|---|---|
| IUPAC Name | (6aR,9R)‑N,N‑diethyl‑7‑methyl‑4‑propionamido‑1‑propionylergoline‑8‑carboxamide |
| Molecular Formula | C₂₃H₂₉N₃O₃ |
| Molecular Weight | 395.49 g·mol⁻¹ |
| Structure Type | Lysergamide (ergoline scaffold + N¹‑propionyl group) |
| Functional Groups | Amide × 2, tertiary amine, indole, alkyl chain |
| Solubility | Slight in water; high in ethanol / methanol |
| pKa (amine) | ≈ 7.5 |
| log P (calc.) | 3.1 |
| Stability | Sensitive to UV light and acid hydrolysis |
| Storage Conditions | ≤ –20 °C; light‑proof sealed vial, under desiccation |
| Physical Form | Paper matrix infused with trace compound (~20 µg per unit) |
Chemical Biology
- Functional Classification: Lysergamide analogue used for metabolic pro‑drug studies.
- Mechanism: In acidic or enzymatic conditions, N‑deacylation yields LSD.
- Research Use: Benchmark compound for receptor binding modeling and metabolic enzyme assays.
- In vitro Analysis: Hydrolysis kinetics assessed via LC‑MS/MS by monitoring 1P‑LSD → LSD conversion curves.
- Biohazard Note: Nanogram potency — handle in a BSL‑2 facility with controlled ventilation.
Computational Chemistry
| Parameter | Value (B3LYP/6‑31G*) |
|---|---|
| Dipole Moment | 3.7 Debye |
| HOMO–LUMO Gap | 5.8 eV |
| Hydrogen Bond Donors / Acceptors | 1 / 5 |
| TPSA | 64 Ų |
| Rotatable Bonds | 6 |
| log P | ≈ 3.1 |
| Lowest Energy Conformer** | Planar ergoline with amide torsion ≈ 34° |
| Modeling Use** | Benchmark in QSAR/QSPR datasets for LSD analogues |
Environmental Chemistry
- Photostability: Rapid loss of mass under ambient light (< 12 h).
- Hydrolysis: Acidic or base‑catalyzed hydrolysis forms LSD and propionic acid.
- Degradation Products: LSD, lysergic acid amides, indole oxidation fragments.
- Kow (log P): ≈ 3.1 → moderate sorption to organic material.
- Biodegradability (28 days): ~35–45 % under aerobic conditions.
- Waste Processing: High‑temperature incineration (≥ 1200 °C) or oxidative neutralization.
Laboratory Equipment
| Instrument | Purpose |
|---|---|
| LC–MS/MS (ESI⁺) | [M + H]⁺ 396.22 → 324.22 m/z (LSD ion transition). |
| HPLC–UV Detection | Retention ≈ 7.8 min (C18, 60:40 MeCN/H₂O + 0.1 % Formic Acid). |
| UV–Vis Spectroscopy | λₘₐₓ ≈ 308 nm (indole π→π* transition). |
| FTIR (ATR) | Amide C=O stretch 1660 cm⁻¹; N–H bend ~ 1550 cm⁻¹. |
| ¹H NMR (CD₃OD) | Characteristic signals at δ 1.1 (CH₃), 3.4 (N‑CH₂), 6.9 (indole region). |
Laboratory Consumables
- Amber vials (PTFE seals) to prevent UV degradation.
- LC‑MS‑grade methanol, acetonitrile, and ultrapure water.
- PTFE filters (0.22 µm) for sample preparation.
- Micro‑blotter cutting tools for controlled unit sampling.
- PPE: nitrile gloves, lab coat, respirator mask if transferring powders.
- Desiccated sample chamber or cold‑storage unit (–20 °C).
Regulation & Safety
| Aspect | Description |
|---|---|
| Controlled Status | Typically classified as an LSD analogue under Schedule I / Class A drug laws (US, UK, EU). |
| Permitted Use | Analytic reference within licensed academic or forensic labs only. |
| Signal Word (GHS) | Danger |
| Hazard Statements | H301 · H311 · H331 · H360 — Toxic if swallowed or inhaled; may damage fertility or fetus. |
| Precautionary Statements | P260 · P280 · P284 — Use respiratory protection; avoid dust/vapor formation. |
| Risk Control Measures | Operate under BSL‑2 hood and controlled access facility. |
| Disposal | Controlled waste incineration under licensed conditions. |
| UN Classification | UN 3462 — Organic toxic solid (n.o.s.) |
Chemical Informatics
| Descriptor | Data |
|---|---|
| SMILES | CCC(=O)N1C=C(C2CCCN3C2CC=C4C3=CN=C(C4)C(=O)N(CC)CC)C=C1 |
| InChIKey | CXXWQIQMWMTJCT‑UHFFFAOYSA‑N |
| Molecular Mass | 395.49 g·mol⁻¹ |
| TPSA | 64 Ų |
| Rotatable Bonds | 6 |
| log P | 3.1 |
| PubChem CID | 153841500 |
| ChemSpider ID | 81587211 |
| Use in Databases | QSAR/QSPR model compound for ergoline analogue evaluation. |
Compliance Notice
⚠️ Controlled‑Substance Advisory
1P‑LSD is treated as a controlled substance analog in many jurisdictions.
Handling, supply, or possession outside licensed scientific or forensic contexts is illegal.This data is provided solely for educational, regulatory, and laboratory informational purposes, not as promotional material.
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