Buy 1P-LSD 150mcg Pellets Online
Buy 1P-LSD 150mcg Pellets is a N‑propionyl derivative of LSD (lysergic acid diethylamide).
The addition of a propionyl group at the indole nitrogen (N1‑position) slightly alters polarity and metabolic behavior but maintains the characteristic ergoline skeleton.
In the 150 µg pellet format, this compound is employed in trace‑analysis calibration, prodrug conversion studies, and controlled reference testing within accredited facilities.
Organic / Inorganic Chemistry
| Property | Value |
|---|---|
| IUPAC Name | (6aR,9R)‑N,N‑diethyl‑7‑methyl‑4‑propionamido‑1‑propionyl‑ergoline‑8‑carboxamide |
| Chemical Formula | C₂₃H₂₉N₃O₂ |
| Molecular Weight | 379.50 g·mol⁻¹ |
| Functional Groups | Amide × 2, tertiary amine, indole aromatic system |
| Physical Form | Off‑white microcrystalline embedded in pellet matrix |
| Solubility | Ethanol, methanol; practically insoluble in water |
| Log P calc. | ≈ 2.9 |
| pKa (amine) | 7.3 |
| Melting Point (decomp.) | ~ 127 °C |
| Storage Conditions | Dark, dry, ≤ –20 °C containers |
| Reactivity Notes | Decomposes by acid hydrolysis and UV radiation |
Chemical Biology
- Functional Class: Prodrug of LSD, generating LSD on in vitro hydrolysis or in enzyme media.
- Mechanistic Interest: Used to study N‑acyl cleavage and ergoline receptor binding models.
- In vitro Use: Applied as a substrate in cytochrome P450 microsome assays and receptor binding profiling.
- Metabolic Pathways: Hydrolytic conversion to LSD + propionic acid.
- Cautions: Nanomolar potency, requiring microgram‑precision instrumentation for handling.
Computational Chemistry
| Parameter | Value (B3LYP/6‑31G*) |
|---|---|
| Dipole Moment | 3.7 Debye |
| HOMO–LUMO Gap | 5.9 eV |
| Rotatable Bonds | 6 |
| TPSA | 62 Ų |
| Hydrogen Bond Donors / Acceptors | 1 / 5 |
| log P (pred.) | 2.9 |
| Molecular Volume | 440 ų |
| Optimized Structure Feature** | Ergoline plane with torsional amide angle ≈ 34° |
| In silico Use** | QSAR benchmark for ergoline analogue activation energies |
Environmental Chemistry
- Photodegradation: Rapid under UV and visible light; half‑life < 6 h in lab conditions.
- Hydrolysis: Accelerated in acidic pH; forms LSD and propionic acid.
- Biodegradation: Partial (≈ 40 % within 28 days, aerobic soil simulation).
- Partition Coefficient (Kow): ~ 2.9 — moderate hydrophobicity.
- Waste Neutralization: Controlled oxidation (NaOCl neutral pH) followed by activated carbon adsorption or high‑temperature incineration (≥ 1200 °C).
- Environmental Impact Assessment: Classified as hazardous waste — avoid water release.
Laboratory Equipment
| Instrument | Analytical Function |
|---|---|
| LC‑MS/MS (ESI⁺) | [M + H]⁺ = 380.22 → 322.22 m/z fragment (LSD ion). |
| HPLC‑UV (220 nm) | Retention ≈ 7.9 min (C18 column, 60/40 MeCN/H₂O + 0.1 % FA). |
| FTIR (ATR) | Amide C=O stretch ≈ 1660 cm⁻¹; Indole bands 1610–1500 cm⁻¹ |
| UV–Vis | λₘₐₓ ≈ 308 nm (indole π→π* band) |
| ¹H NMR (CD₃OD) | Characteristic indole signals ~ 7.0 ppm; Et₂N protons ~ 3.3 ppm. |
Laboratory Consumables
- LC‑MS‑grade methanol, acetonitrile, and water.
- Amber autosampler vials (to minimize UV degradation).
- 0.22 µm PTFE syringe filters.
- Analytical balances (0.001 mg precision or better).
- Nitrile gloves, lab coats, and face protection.
- Desiccant‑pack containers for storage of pellets.
Regulation & Safety
| Aspect | Information |
|---|---|
| Legal Classification | LSD analogue — controlled under Schedule I / Class A in multiple jurisdictions. |
| Scope of Use | Forensic standards / licensed analytical labs only. |
| Signal Word (GHS) | Danger |
| Hazard Statements | H301 · H311 · H331 · H360 — Toxic if swallowed or inhaled; may damage reproductive health. |
| Precautionary Statements | P260 · P280 · P284 · P501 – Avoid exposure, use PPE, dispose via controlled incineration. |
| Disposal Guidelines | Send for destruction via licensed chemical waste contractor. |
| Documentation Requirement | Controlled‑substance register entry + chain of custody records. |
Chemical Informatics
| Descriptor | Value |
|---|---|
| SMILES | CCC(=O)N1C=C(C2CCCN3C2CC=C4C3=CN=C(C4)C(=O)N(CC)CC)C=C1 |
| InChIKey | KDXQNBOJNSEWHS‑UHFFFAOYSA‑N |
| Molecular Mass | 379.50 g·mol⁻¹ |
| TPSA | 62 Ų |
| Rotatable Bonds | 6 |
| log P | 2.9 |
| PubChem CID | 137964585 |
| ChemSpider ID | 78619960 |
| QSAR Applications | Used as a reference in lysergamide activity predictive modeling datasets |
Compliance Notice
⚠️ Controlled Substance Advisory
1P‑LSD is classified as a Schedule I / Class A controlled analogue in the United States, United Kingdom, European Union, and most countries.
Possession or use is restricted to licensed research entities with appropriate authorization.This information is for forensic, academic, and regulatory reference purposes only and not for advertising or human administration.
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