Buy 1cP-MiPLA 200mcg Blotters Online
Buy 1cP-MiPLA 200mcg Blotters is a semisynthetic lysergamide, belonging to the ergoline family.
It is a 1‑cyclopropanoyl derivative of MiPLA (N‑methyl‑N‑isopropyl lysergamide), studied exclusively as an analytical standard in controlled‑substance research.
The 200 µg blotter format allows calibrated sampling for LC‑MS, GC‑MS, and FTIR method verification.
Organic / Inorganic Chemistry
| Parameter | Specification |
|---|---|
| IUPAC Name | (6aR,9R)‑N,N‑di(isopropyl)‑7‑methyl‑4‑cyclopropanecarboxamido‑ergoline‑8‑carboxamide |
| Molecular Formula | C₂₄H₃₁N₃O₂ |
| Molar Mass | 393.52 g·mol⁻¹ |
| Functional Groups | Indole, tertiary amine, cyclopropanecarboxamide, amide linkages |
| Physical Form | Impregnated paper substrate, off‑white appearance |
| Melting Point (decomp.) | ≈ 126 °C |
| Solubility | Soluble in MeOH / EtOH; low in aqueous solutions |
| log P (calc.) | ≈ 2.8 |
| pKa (amine) | 7.1 |
| UV λₘₐₓ | ≈ 307 nm |
| Stability | Degrades on exposure to UV and humidity; store dark ≤ –20 °C |
Chemical Biology
- Class: Lysergamide ergoline analog.
- Research Purpose: Analytical standard for identification of novel prodrug lysergamides and their hydrolysis products.
- Metabolic pattern studied in vitro: Hydrolytic removal of cyclopropionyl group to yield MiPLA.
- Biochemical context: Prodrug mechanisms for N¹‑substituted ergolines; useful in enzymatic cleavage kinetics modelling.
- Toxicological note: Extremely potent psychoactive analogue — must not be handled outside licensed laboratories.
Computational Chemistry
| Property | DFT (B3LYP/6‑31G*) Estimate |
|---|---|
| Dipole Moment | 3.5 D |
| HOMO‑LUMO Gap | 5.9 eV |
| Topological Polar Surface Area** | 61 Ų |
| Hydrogen Bond Donors / Acceptors | 1 / 5 |
| Rotatable Bonds | 6 |
| Molecular Volume | ~ 450 ų |
| Predicted log P | 2.8 |
| Conformational Traits | Cyclopropyl‑amide torsion ~ 29°; indole planarity |
| Applications | QSAR/QSPR modelling for N‑substituted ergoline analogues |
Environmental Chemistry
- Photolytic Stability: Rapid UV breakdown; half‑life < 5 h.
- Hydrolysis: Deacylation to MiPLA and cyclopropionic acid in aqueous acidic conditions.
- Biodegradation: Partial (≈ 35 % in aerobic soil over 28 days).
- Partition Coefficient (log Kow): 2.8 — moderate bioaccumulation potential.
- Waste Disposal: Controlled oxidation in NaOCl solution (pH 7–8) → activated‑carbon filtration → incineration.
- Environmental Protection: Avoid release; considered toxic organic waste under hazard codes T61.
Laboratory Equipment
| Instrument | Analytical Purpose |
|---|---|
| LC‑MS/MS (ESI⁺) | [M + H]⁺ = 394.23 → 322.22 m/z (exhibits fragment consistent with LSD core). |
| HPLC‑UV (220 nm) | Retention ≈ 7.6 min on C18 60:40 MeCN/H₂O + 0.1 % FA. |
| GC‑MS (EI) | Fragment pattern confirming cyclopropionyl cleavage. |
| FTIR (ATR) | C=O amide band 1654 cm⁻¹; indole stretch 1610 cm⁻¹. |
| UV–Vis Spectroscopy | Qualitative λₘₐₓ ≈ 307 nm. |
| Microbalance (0.001 mg) | Micro‑dose preparation and calibration. |
Laboratory Consumables
- LC‑MS‑grade methanol and acetonitrile.
- Ultrapure water (> 18 MΩ cm).
- PTFE syringe filters (0.22 µm).
- Amber HPLC vials with PTFE/silicone caps.
- Nitrile gloves, safety glasses, and lab coats.
- Desiccators with silica gel for storage.
- Inert‑gas (sealed nitrogen bags) for long‑term sample protection.
Regulation & Safety
| Aspect | Details |
|---|---|
| Legal Classification | Schedule I / Class A — controlled lysergamide analogue in EU, UK, US. |
| Permitted Use | Analytical reference only under licence. |
| Hazard Pictograms | ☣️ (acute toxicity) ⚠️ (reproductive hazard) |
| Signal Word (GHS) | Danger |
| Hazard Statements | H300, H310, H330 — fatal if ingested / inhaled / contact with skin; H360 — may damage fertility. |
| Precautionary Statements | P260, P280, P284, P501 — Avoid inhalation, wear PPE, dispose through licensed hazmat contractors. |
| Emergency Spill Procedure | Neutralize with activated carbon; avoid aerosol formation; incinerate residual waste. |
| Transport Regulation | UN 3462 (Toxic solid, organic n.o.s). |
Chemical Informatics
| Descriptor | Data |
|---|---|
| SMILES | CC(C)N(C)C(=O)N1C=C(C2CCCN3C2CC=C4C3=CN=C(C4)C(=O)N(CC1)C1CC1) |
| InChIKey | FTYNSCCYZNCDLS‑UHFFFAOYSA‑N |
| Molecular Weight | 393.52 g·mol⁻¹ |
| TPSA | 61 Ų |
| Rotatable Bonds | 6 |
| log P | ~ 2.8 |
| Database Reference | Analogous entries in Ergoline QSAR datasets (ChEMBL / PubChem custom collections). |
| Computational Application | Training set for lysergamide hydrolysis and binding model simulation. |
Compliance Notice
⚠️ Controlled Substance Advisory
1cP‑MiPLA is a Schedule I / Class A analogue of LSD, regulated under controlled‑substance legislation throughout the US, UK, and EU.
Possession, synthesis, or distribution is illegal unless authorized under a specific laboratory license.This information is provided solely for educational and forensic reference and must not be interpreted as promotion or encouragement of use.
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