Buy 2‑FMA Powder Online — Analytical Reference Material
2‑Fluoromethamphetamine (Buy 2‑FMA Powder ) is a fluorinated derivative of methamphetamine from the β‑phenethylamine and substituted amphetamine family.
It is utilized as an analytical and calibration reference in mass‑spectrometry, gas chromatography, toxicological screening, and computational modeling of monoaminergic ligands.
The powder form permits controlled gravimetric preparation of standard solutions and forensic assays.
Organic / Inorganic Chemistry
| Property | Specification |
|---|---|
| IUPAC Name | 1‑(2‑fluorophenyl)‑N‑methylpropan‑2‑amine |
| Formula | C₁₀H₁₄FN |
| Molecular Weight | 167.22 g mol⁻¹ |
| Chemical Family | Fluoro‑phenethylamines |
| Physical State | White to off‑white crystalline powder |
| Functional Groups | Aromatic ring, secondary amine, fluorine substituent |
| pKa (amine) | 9.8 |
| Boiling Point | ≈ 232 °C |
| Melting Point (free base) | ≈ 174 °C |
| log P (pred.) | 2.1 |
| Solubility | Soluble in ethanol and methanol; partially soluble in water |
| Storage | ≤ –20 °C, desiccated and light‑protected |
| Purity (Analytical) | ≥ 99 % verified by HPLC / GC–MS |
Chemical Biology
- Class: Monoamine releasing agent (amphetamine analogue).
- Research Use: Structure–activity relationship (SAR) reference for fluorine substitution effects on neurotransmitter transporter affinity.
- Mechanistic Data: Acts as a substrate for dopamine and norepinephrine reuptake transporters.
- Metabolism (in vitro): N‑demethylation and deamination → formation of 2‑fluorophenylacetone and oxidized acid metabolites.
- Toxicology: Potent sympathomimetic — requires strict containment and professional handling.
- Biological Assay Use: In receptor binding and in silico pharmacokinetic model validation.
Computational Chemistry
| Descriptor | Value (B3LYP/6‑31G*) |
|---|---|
| Dipole Moment | 2.72 Debye |
| HOMO‑LUMO Gap | 5.83 eV |
| Hydrogen‑Bond Donors | 1 |
| Hydrogen‑Bond Acceptors | 2 |
| Rotatable Bonds | 3 |
| Molecular Surface Area (TPSA)** | 32 Ų |
| log P (calc.) | 2.1 |
| DAT Binding Energy (in silico)** | –9.0 kcal mol⁻¹ |
| NET Binding Energy (in silico)** | –8.5 kcal mol⁻¹ |
| QSAR Significance** | Descriptor case for para‑/ortho fluoro‑substituent influence on activity |
Environmental Chemistry
- Environmental Stability: Stable at ambient conditions; slow degradation via oxidation.
- Hydrolysis: Negligible under neutral pH.
- Photolysis Half‑Life: ≈ 6 h at λ = 355 nm.
- Partition Coefficient (log Kow): 2.1 — minimal bioaccumulation.
- Biodegradation Potential: Low; fluorine atom confers chemical stability.
- Primary Degradation Products: Fluoro‑benzoic acid and N‑oxide intermediates.
- Waste Treatment: Advanced oxidation (AOP / ozone / UV + H₂O₂) or thermal incineration ≥ 1100 °C.
Laboratory Equipment
| Instrument | Analytical Purpose |
|---|---|
| LC–MS/MS (ESI⁺) | [M + H]⁺ = 168 m/z → major product ions 150 and 119 m/z |
| GC–MS (EI) | Molecular ion 167 m/z, base peak 44 m/z |
| FTIR (ATR) | C–F stretch ~ 1100 cm⁻¹, N–H stretch 3300 cm⁻¹ |
| ¹H NMR (CDCl₃) | δ 7.0–7.3 (aromatic H), 2.8 (N‑CH₃), 1.2 (iso‑CH₃) |
| HPLC Conditions | C18 column; ACN:H₂O (60:40 + 0.1 % FA); Retention ≈ 4.0 min |
Laboratory Consumables
- LC–MS grade solvents (acetonitrile, methanol).
- Amber glass vials (2 mL) with PTFE septa.
- 0.22 µm PTFE syringe filters.
- Calibrated pipettes and Class A volumetrics.
- Analytical microbalances (± 0.01 mg).
- PPE: nitrile gloves, lab coat, chemical goggles, positive‑pressure respirator if dust risk exists.
Regulation & Safety
| Aspect | Detail |
|---|---|
| Legal Classification | Controlled substance — Schedule I (US), Class A (UK), Annex I (EU) |
| Permitted Activity | Forensic reference standards under approved license only |
| GHS Signal Word | Danger |
| Hazard Statements | H301, H311, H331 — Toxic via oral, dermal, inhalation routes |
| Precautionary Statements | P260, P280 — Avoid dust inhalation / use PPE |
| First Aid Measures | Rinse skin with soap and water; seek medical advice immediately |
| Spill Response | Contain using inert material (vermiculite); seal for destruction |
| Waste Disposal | High‑temperature incineration ≥ 1100 °C via licensed facility |
| Transport | UN 2811 · Toxic solid, organic, n.o.s. · Packaging Group I |
Chemical Informatics
| Field | Entry |
|---|---|
| SMILES | CC(CC1=CC=CC=C1F)NC |
| InChIKey | YBBNCOLWZSHXTK-UHFFFAOYSA-N |
| Molecular Weight | 167.22 g mol⁻¹ |
| TPSA | 32 Ų |
| Rotatable Bonds | 3 |
| log P (calc.) | 2.1 |
| CAS Registry Number | not officially assigned (public registry inactive) |
| Database Cross‑Refs | PubChem CID 118796969 · ChemSpider 55386749 · Open Forensics DB |
| QSAR Role | Benchmark ligand for fluorinated amphetamine training sets |
Compliance Notice
⚠️ Controlled‑Substance Advisory
2‑Fluoromethamphetamine and its salts are listed as Schedule I / Class A psychoactive compounds in multiple jurisdictions.
Possession or distribution is restricted to licensed forensic facilities and authorized scientific entities.
The data above are intended solely for educational and regulatory reference purposes. This document must not be used for promotion, sale, or consumption.
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