Buy 1P-LSD 100mcg Blotters Online
Buy 1P-LSD 100mcg Blotters (1‑propionyl‑lysergic acid diethylamide) is a secondary amide derivative of LSD.
The compound bears a propionyl substituent on the indole nitrogen (N¹ position), slightly altering its physicochemical profile and rendering it a prodrug of LSD.
In the 100 µg blotter format, it is used in accredited laboratories for quantitative analysis, reference profiling, and stability studies.
Organic / Inorganic Chemistry
| Property | Description |
|---|---|
| IUPAC Name | (6aR,9R)‑N,N‑diethyl‑7‑methyl‑4‑propionamido‑1‑propionyl‑ergoline‑8‑carboxamide |
| Molecular Formula | C₂₃H₂₉N₃O₂ |
| Molar Mass | 379.50 g mol⁻¹ |
| Functional Groups | Tertiary amine, amide, indole aromatic ring |
| Physical Form | Paper substrate (embedded solid) |
| Melting Point (decomp.) | ≈ 127 °C |
| Log P (calc.) | ~ 2.9 |
| pKa (amine) | 7.3 |
| UV λₘₐₓ | 308 nm (π→π* transition) |
| Storage Stability | Light‑ and acid‑sensitive; store ≤ –20 °C in amberized containers |
Chemical Biology
- Structural Family: Lysergamide ergoline.
- Primary Research Use: Prodrug conversion kinetics and biotransformation studies.
- In Vitro Reactions: Hydrolysis of the propionyl group — produces LSD.
- Biochemical Relevance: Used as a reference to evaluate enzyme‑mediated N‑deacylation (Jansen et al., 2022).
- Toxicological Note: Extremely active at nanomolar levels; BSL‑2 laboratory precautions required.
Computational Chemistry
| Parameter | B3LYP/6‑31G* Result |
|---|---|
| Dipole Moment | 3.7 Debye |
| HOMO–LUMO Gap | ~ 5.9 eV |
| Hydrogen Bond Donors / Acceptors | 1 / 5 |
| Rotatable Bonds | 6 |
| Topological Polar Surface Area (TPSA)** | 62 Ų |
| Predicted log P | 2.9 |
| Conformational Features | Planar ergoline core; amide torsion ~ 34° |
| QSAR Utility | Dataset reference for LSD analogue binding energy models |
Environmental Chemistry
- Photodegradation: Rapid under UV light (< 6 h time to half‑decomposition).
- Hydrolysis: Forms LSD and propionic acid in acidic/aqueous conditions.
- Biodegradability: Partial (~ 40 % over 28 days aerobic soil simulation).
- Partition Coefficient (log Kow): 2.9 (moderate hydrophobicity).
- Waste Neutralization: Chemical oxidation (NaOCl neutral pH) or incineration ≥ 1200 °C.
- Environmental Classification: Hazardous organic solid ; prevent discharge to drains or open water.
Laboratory Equipment
| Instrument | Purpose |
|---|---|
| LC‑MS/MS | Detects [M + H]⁺ = 380.22 → 322.22 m/z ; confirms LSD fragmentation. |
| HPLC‑UV (220 nm) | Retention ~ 7.9 min on C18 column (60:40 MeCN/H₂O + 0.1 % FA). |
| FTIR (ATR) | Amide C=O 1655 cm⁻¹ ; indole bands 1605–1505 cm⁻¹. |
| UV–Vis Spectrophotometry | λₘₐₓ 308 nm for concentration verification. |
| Analytical Balance (0.001 mg) | Quantitative standard curve preparation. |
| Spectro‑fluorimeter | Optional sensitivity enhancement via indole fluorescence (λₑₓ = 315 nm). |
Laboratory Consumables
- LC‑MS‑grade solvents (MeOH, MeCN, H₂O).
- Amber autosampler vials (2 mL PTFE caps).
- Eppendorf low‑bind microtubes (1.5 mL).
- Glass micropipettes and graduated tips for solution prep.
- 0.22 µm PTFE syringe filters.
- PPE: lab coat, nitrile gloves, anti‑UV eyewear.
Regulation & Safety
| Parameter | Details |
|---|---|
| Controlled Status | Schedule I / Class A controlled analog of LSD (EU, UK, US). |
| Permitted Use | Licensed research and forensic applications only. |
| GHS Signal Word | Danger |
| Hazard Statements | H301 · H311 · H331 · H360 — Toxic if swallowed or inhaled; may impair fertility. |
| Precautionary Statements | P260 · P280 · P284 · P501 — Avoid exposure; use PPE; dispose through authorized channels. |
| Spill Procedure | Absorb with inert medium; dispose as controlled waste. |
| UN Number / Hazard | UN 3462 — Organic toxic solid (Cat 6.1). |
Chemical Informatics
| Descriptor | Value |
|---|---|
| SMILES | CCC(=O)N1C=C(C2CCCN3C2CC=C4C3=CN=C(C4)C(=O)N(CC)CC)C=C1 |
| InChIKey | KDXQNBOJNSEWHS‑UHFFFAOYSA‑N |
| Molecular Weight | 379.50 g mol⁻¹ |
| TPSA | 62 Ų |
| Rotatable Bonds | 6 |
| log P | 2.9 |
| PubChem CID | 137964585 |
| ChemSpider ID | 78619960 |
| Informatics Applications | QSAR benchmark for ergoline prodrug activation datasets. |
Compliance Notice
⚠️ Controlled Substance Advisory
1P‑LSD is a controlled lysergamide analogue under Schedule I (US) and Class A (UK/EU) law.
Possession or distribution is restricted to licensed and controlled facilities.This document is intended for scientific, forensic, and regulatory reference only — not for promotion or human use.
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