Buy 2‑FMA Capsules 50mg Online — Analytical Reference Standard
Buy 2‑FMA Capsules 50mg (2‑fluoromethamphetamine) is a substituted amphetamine derivative in the fluoro‑phenethylamine chemical family.
It is primarily used as a reference and calibration compound in forensic toxicology, LC–MS/MS libraries, and computational drug profiling research.
The encapsulated 50 mg reference form provides precise handling for quality‑assured analytical workflows.
Organic / Inorganic Chemistry
| Parameter | Value |
|---|---|
| IUPAC Name | 1‑(2‑fluorophenyl)‑N‑methylpropan‑2‑amine |
| Molecular Formula | C₁₀H₁₄FN |
| Molecular Weight | 167.22 g mol⁻¹ |
| Chemical Class | Fluoro‑substituted amphetamines |
| Appearance | White to off‑white microcrystalline powder (50 mg capsules) |
| Functional Groups | Aromatic ring, secondary amine, fluoro substitution |
| pKa (amine) | 9.8 |
| log P (pred.) | 2.1 |
| Melting Point (free base) | ≈ 173 °C |
| Boiling Point (free base) | ≈ 230 °C |
| Storage | ≤ –20 °C, in amber airtight container |
| Purity | ≥ 99 % (by HPLC / MS verification) |
Chemical Biology
- Mechanistic Profile: Indirect sympathomimetic acting as dopamine and norepinephrine transporter substrate.
- Scientific Application: Used to validate mass spectral libraries of amphetamine analogues and study the effect of fluoro substitution on monoamine reuptake affinity.
- Biochemical Metabolism (in vitro): N‑demethylation → deamination → oxidation to 2‑fluorophenylacetone and benzoic acid derivatives.
- Toxicology: Potent CNS stimulant — microgram quantities require Class A controlled handling.
- Biosafety: Handle under BSL‑2 conditions with fume hood and respiratory PPE.
Computational Chemistry
| Descriptor | B3LYP/6‑31G* Value |
|---|---|
| Dipole Moment | 2.72 D |
| HOMO–LUMO Gap | 5.83 eV |
| Hydrogen‑Bond Donors | 1 |
| Hydrogen‑Bond Acceptors | 2 |
| Rotatable Bonds | 3 |
| Polar Surface Area (TPSA)** | 32 Ų |
| Binding Energy (DAT model)** | –9.0 kcal mol⁻¹ |
| Binding Energy (NAT model)** | –8.6 kcal mol⁻¹ |
| SAR Use** | Reference ligand for fluorinated amphetamine QSAR training sets. |
Environmental Chemistry
- Persistence: Stable under neutral aqueous conditions.
- Photolytic Half‑Life: ≈ 6 h (λ = 355 nm).
- Volatility: Low (vapor pressure ≈ 2 × 10⁻⁵ mm Hg at 20 °C).
- Partition Coefficient (log Kow): 2.1 — low bioaccumulation potential.
- Degradation: Oxidation → fluoro‑benzoic acid and amine oxides.
- Recommended Waste Treatment: Advanced oxidation (ozone / UV/H₂O₂) or thermal incineration ≥ 1100 °C.
Laboratory Equipment
| Instrument | Analytical Purpose |
|---|---|
| LC–MS/MS (ESI⁺) | [M + H]⁺ = 168 m/z → fragments 150 and 119 m/z |
| GC–MS (EI) | Molecular ion 167 m/z · base peak 44 m/z |
| FTIR (ATR) | N–H stretch 3300 cm⁻¹ · C–F stretch 1100 cm⁻¹ · Aromatic bands 1600 cm⁻¹ |
| ¹H NMR (CDCl₃) | δ 7.0–7.3 (aromatic), 2.8 (CH₂N), 1.2 (CH₃) |
| HPLC Conditions | C18 column, ACN:H₂O (60:40 + 0.1 % formic acid), Rt ≈ 4.0 min |
Laboratory Consumables
- LC–MS‑grade methanol and water.
- Disposable PTFE‑lined vials (2 mL amber).
- 0.22 µm PTFE filters.
- Calibrated micropipettes (Class A).
- PPE: nitrile gloves, lab coat, sealed goggles, P3 respirator or fume hood use.
- Absorbent spill mats and chemical‑resistant waste containers.
Regulation & Safety
| Category | Details |
|---|---|
| Legal Status | Controlled substance (analogue of methamphetamine) · Schedule I/Class A status in most regions. |
| Authorized Use | Certified forensic and academic laboratories under license. |
| GHS Signal Word | Danger |
| Hazard Statements | H301, H311, H331 — Toxic if swallowed, inhaled, or in contact with skin. |
| Precautionary Statements | P260, P280, P284 — Use PPE, avoid dust/vapor inhalation. |
| Storage Class | 6.1B Toxic Solids (TRGS 510). |
| Waste Disposal | Incineration via licensed facility ≥ 1100 °C or validated chemical destruction process. |
Chemical Informatics
| Field | Entry |
|---|---|
| SMILES | CC(CC1=CC=CC=C1F)NC |
| InChIKey | YBBNCOLWZSHXTK-UHFFFAOYSA-N |
| Molecular Mass | 167.22 g mol⁻¹ |
| TPSA | 32 Ų |
| log P (calc.) | 2.1 |
| Rotatable Bonds | 3 |
| Chemical Use Category | Analytical reference standard · computational receptor model testing. |
| Database Cross‑Reference | PubChem CID 118796969 · ChemSpider Ref. 55386749 |
Compliance Notice
⚠️ Controlled Substance Advisory
2‑Fluoromethamphetamine and its salts are classified as Schedule I (US), Class A (UK), and Annex I (EU) controlled stimulants.
Possession and use are restricted to licensed forensic and academic facilities.
This information is provided solely for educational and regulatory reference purposes, not for promotion, sale, or human consumption.
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