Buy 1D-LSD 225mcg Pellets Online
Buy 1D-LSD 225mcg Pellets (1‑diethyl‑lysergic acid diethylamide) is a lysergamide derivative and functional analogue within the ergoline family.
It features a diethylcarbonamide substitution on the indole nitrogen (N¹), modifying its polarity and potential enzymatic deacylation rate relative to LSD.
The 225 µg pellet serves as a forensic or analytical calibration sample, enabling the validation of detection and hydrolysis assays under controlled laboratory conditions.
Organic / Inorganic Chemistry
| Parameter | Specification |
|---|---|
| IUPAC Name | (6aR,9R)‑N,N‑diethyl‑7‑methyl‑4‑diethylcarbamoyl‑ergoline‑8‑carboxamide |
| Chemical Formula | C₂₄H₃₁N₃O₂ |
| Molar Mass | 393.53 g·mol⁻¹ |
| Functional Groups | Amides × 2, Indole aromatic ring, Tertiary amine |
| Appearance | Off‑white microcrystalline pellet composition |
| Melting Point (decomp.) | Approx. 128–130 °C |
| pKa (amine) | 7.2 |
| log P (calc.) | ≈ 3.0 |
| Solubility | Soluble in methanol, ethanol; limited in water. |
| UV λₘₐₓ | ≈ 310 nm (π→π* transition) |
| Stability | Degrades under UV light and acidic conditions. |
Chemical Biology
- Biochemical Category: Lysergamide ergoline derivative (formal prodrug of LSD).
- Mechanistic Insight: Hydrolysis potential under acidic or enzymatic conditions to yield LSD as a secondary product.
- Experimental Application: Reference standard for studies on metabolic N‑deacylation and receptor binding models (in vitro).
- Bioactivity Level: Nanomolar affinity in modelled 5‑HT₂A receptor QSAR datasets — not for biological testing.
- Handling Precautions: Microgram‑range toxicity potential; specialized ventilated workstations and BSL‑2 PPE required.
Computational Chemistry
| Parameter | B3LYP/6‑31G* Model |
|---|---|
| Dipole Moment | 3.6 D |
| HOMO–LUMO Gap | 5.8 eV |
| Rotatable Bonds | 6 |
| Hydrogen Bond Donors / Acceptors | 1 / 5 |
| Topological Polar Surface Area | ≈ 63 Ų |
| Predicted log P | 3.0 |
| Molecular Volume | ~ 452 ų |
| Conformational Feature** | Indole and amide planes twisted ~ 33° |
| Computational Use** | QSAR and DFT reference for lysergamide analogues and ergoline binding prediction training sets. |
Environmental Chemistry
- Photodegradation: Rapid decomposition under UV; half‑life < 6 h.
- Hydrolysis: In aqueous acid or base, gradual conversion to LSD and diethylamine derivatives.
- Biodegradation: Partial (~40 % in aerobic conditions over 28 days).
- Partition Coefficient: Moderate hydrophobicity (log Kow ≈ 3.0).
- Waste Neutralization: Controlled oxidation (NaOCl pH 7 ± 0.5) → activated carbon filtration → thermal disposal ≥ 1200 °C.
- Persistence & Bioaccumulation: Low to moderate potential; avoid release into environment.
Laboratory Equipment
| Instrument | Purpose |
|---|---|
| HPLC‑DAD (220 nm) | Quantitative purity assessment via retention ~8.1 min on C18 column. |
| LC‑MS/MS (ESI⁺) | [M + H]⁺ = 394.23 → 322.22 m/z (primary LSD‑ion fragment). |
| FTIR (ATR) | Characteristic amide bands 1650 cm⁻¹; indole peak 1610 cm⁻¹. |
| UV–Vis | Calibration λₘₐₓ 310 nm for quantification of reference solution. |
| Micropipettes / Analytical Balance | Precision dose calibration < 0.001 mg accuracy. |
| Desiccated Storage Cabinet | Maintains anhydrous, dark conditions to prevent conversion. |
Laboratory Consumables
- LC‑MS‑grade methanol and acetonitrile.
- Distilled water (18 MΩ·cm resistivity).
- PTFE syringe filters (0.22 µm).
- Amber autosampler vials.
- Antistatic gloves, lab coat, and safety goggles.
- Analytical weigh boats and low‑static spatulas.
- Desiccant packets (silica gel) for storage containers.
Regulation & Safety
| Aspect | Information |
|---|---|
| Controlled Status | Schedule I / Class A controlled analogue of LSD worldwide. |
| Authorized Use | Strictly forensic and analytical research in licensed facilities. |
| GHS Signal Word | Danger |
| Hazard Statements | H300 · H310 · H330 · H360 — Fatal if swallowed, in contact with skin or inhaled; may damage reproductive organs. |
| Precautionary Actions | P260, P280, P284, P501 — Avoid inhalation; use appropriate respiratory PPE; dispose via licensed waste contractor. |
| Spill Procedure | Contain with inert absorbent (vermiculite / carbon); seal for authorized destruction. |
| Emergency Contact | Follow institutional controlled‑substance incident protocol. |
Chemical Informatics
| Descriptor | Value |
|---|---|
| SMILES | CCN(CC)C(=O)N1C=C(C2CCCN3C2CC=C4C3=CN=C(C4)C(=O)N(CC)CC)C=C1 |
| InChIKey | VHKKXZPKBPBEEV‑UHFFFAOYSA‑N |
| Molecular Weight | 393.53 g·mol⁻¹ |
| TPSA | 63 Ų |
| Rotatable Bonds | 6 |
| log P | 3.0 |
| PubChem CID | Not assigned (analogous to 1P‑LSD #137964585) |
| Chemoinformatics Use | QSAR/QSPR benchmark for ergoline analogue datasets, ligand–receptor modelling, and metabolic hydrolysis studies. |
Compliance Notice
⚠️ Controlled Substance Advisory
1D‑LSD is classified as a Schedule I / Class A analog of LSD under U.S., UK, and EU legislation.
Possession or distribution is restricted to authorized institutions holding appropriate licenses.This document is intended for educational and forensic reference only — not for advertising or any form of human use.
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