Buy 2‑FA Powder Online — Analytical Reference Standard
2‑Fluoroamphetamine (Buy 2‑FA Powder) is a fluoro‑substituted derivative of amphetamine belonging to the phenethylamine and substituted amphetamine chemical families.
Its main legitimate role is in forensic calibration, toxicological method development, and computational chemistry studies on how fluorine substitution affects pharmacodynamics and chemical stability.
Organic / Inorganic Chemistry
| Property | Details |
|---|---|
| IUPAC Name | 1‑(2‑fluorophenyl)propan‑2‑amine |
| Chemical Formula | C₉H₁₂FN |
| Molecular Weight | 153.19 g mol⁻¹ |
| Functional Groups | Aromatic ring, secondary amine, fluoro substituent |
| Physical State | White to off‑white crystalline powder |
| Boiling Point | ≈ 212 °C (under reduced pressure) |
| Melting Point | ≈ 168 °C (free base) |
| pKa (amine) | 9.8 |
| log P (pred.) | 1.9 |
| Storage Conditions | ≤ –20 °C, dry, light‑protected |
| Purity (analytical grade) | ≥ 99 % by GC–MS/¹H NMR verification |
Chemical Biology
- Classification: Reference compound for monoamine releasing agents (SAR studies).
- Research Relevance: Used to model transport affinity of fluorinated stimulant structures.
- Mechanistic Insights: Acts as a substrate at dopamine and norepinephrine transporters in vitro.
- Metabolic Pathways: N‑deamination produces 2‑fluorophenylacetone → oxidized benzoic acid derivatives.
- Biosafety classification: Toxic; handled under BSL‑2 conditions.
Computational Chemistry
| Descriptor | B3LYP/6‑31G* Result |
|---|---|
| Dipole Moment | 2.73 Debye |
| HOMO–LUMO Gap | ≈ 5.88 eV |
| Hydrogen‑Bond Donors / Acceptors | 1 / 1 |
| Rotatable Bonds | 2 |
| Topological Surface Area (TPSA)** | 26 Ų |
| log P (calc.) | 1.9 |
| Binding Energy (DAT, pred.) | –9.1 kcal mol⁻¹ |
| Binding Energy (NET, pred.) | –8.7 kcal mol⁻¹ |
| Computational Application** | Benchmark for fluoro‑substituted phenethylamine interaction modelling |
Environmental Chemistry
- Physical Persistence: Moderately stable organic solid.
- Hydrolysis: Negligible under neutral pH.
- Photolysis Half‑Life: ~ 6 h (355 nm UV).
- Partition Coefficient (log Kow): ≈ 1.9 → low bioaccumulation potential.
- Degradation Products: 2‑fluorobenzaldehyde and fluorobenzoic acids.
- Treatment and Disposal: Advanced oxidation processes (AOP) or thermal incineration ≥ 1100 °C.
Laboratory Equipment
| Instrument | Analytical Use |
|---|---|
| GC–MS (EI) | Molecular ion m/z 153; fragments 44, 119. |
| LC–MS/MS (ESI⁺) | [M + H]⁺ = 154 m/z → products 136 / 119. |
| FTIR (ATR) | ν(C–F) ≈ 1100 cm⁻¹ ; ν(N–H) ≈ 3330 cm⁻¹. |
| ¹H NMR (CDCl₃) | δ 7.0–7.3 (aromatic H), 2.8 (N‑CH₃), 1.1 (alkyl CH₃). |
| HPLC | C18 column; ACN:H₂O 60:40 + 0.1 % FA; Retention ≈ 3.8 min. |
Laboratory Consumables
- LC–MS grade acetonitrile and methanol.
- Amber autosampler vials with PTFE septa (2 mL).
- 0.22 µm PTFE syringe filters.
- Certified Class A volumetric glassware.
- Analytical balance (±0.01 mg precision).
- PPE: Nitrile gloves, protective coat, chemical goggles, respiratory mask (P3).
- Hazardous waste containers for incineration‑bound residue.
Regulation & Safety
| Item | Data |
|---|---|
| Control Status | Schedule I (US), Class A (UK), Annex I (EU 2021/90) |
| Authorized Use | Reference material for licensed forensic facilities only. |
| GHS Classification | Acute toxicity (oral, dermal, inhalation) Category 2. |
| Hazard Codes | H301, H311, H331 – Toxic in contact with skin, if swallowed, or inhaled. |
| Precautionary Codes | P260, P280, P302 + P352 – Avoid respiration; wear PPE. |
| Emergency Measures | Flush affected area with water; seek medical attention. |
| Waste Disposal | Route through licensed hazardous waste channels. |
Chemical Informatics
| Descriptor | Entry |
|---|---|
| SMILES | CC(CC1=CC=CC=C1F)N |
| InChIKey | BNXGQPQXQPKVNO‑UHFFFAOYSA‑N |
| Molecular Mass | 153.19 g mol⁻¹ |
| TPSA | 26 Ų |
| Rotatable Bonds | 2 |
| log P (calc.) | 1.9 |
| PubChem CID | 118796970 |
| ChemSpider ID | 55386744 |
| QSAR Role | Training molecule for fluorinated amphetamine binding models. |
Compliance Notice
⚠️ Controlled Substance – Legal Disclaimer
2‑Fluoroamphetamine and its salts are regulated under Schedule I / Class A drug control legislation.
Possession or use is restricted to authorized scientific and forensic entities under appropriate licensing.
This document is for educational and regulatory information purposes only — not marketing material or any endorsement of sale or administration.
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