Buy 4F-MAR Powder Online – (4‑Fluoromethamphetamine) Powder — Analytical Reference Material
Buy 4F-MAR powder, or 4‑fluoromethamphetamine, is a halogenated ring‑substituted phenethylamine and a structural analogue of methamphetamine.
It serves as a research analyte for toxicology, metabolite identification, and SAR (structure–activity relationship) modeling of fluorinated amphetamines and related psychoactive substances.
Organic / Inorganic Chemistry
| Property | Details |
|---|---|
| IUPAC Name | N‑methyl‑1‑(4‑fluorophenyl)propan‑2‑amine |
| Formula | C₁₀H₁₄FN |
| Molecular Weight | 167.22 g · mol⁻¹ |
| Functional Groups | Secondary amine (N‑CH₃), fluoro‑aryl ring, aliphatic chain (C₃) |
| Chemical class | Halogenated amphetamines (phenethylamine core) |
| Physical State | Crystalline powder; hygroscopic. |
| Melting Point (HCl salt) | ≈ 174–176 °C |
| Solubility | Freely soluble in ethanol and methanol; limited in water. |
| Chemical Stability | Stable in dry dark storage at ≤ 25 °C. Degrades under UV or strong acid/base. |
Chemical Biology
- Mechanism: Indirect sympathomimetic; strong dopamine (norepinephrine) releaser.
- Receptor/Transporter targeting: Elevated affinity for DAT and NET relative to MAT baseline structures.
- Metabolic pathway: N‑demethylation → 4‑fluoroamphetamine + formaldehyde; oxidation by CYP2D6 and MAO‑A → 4‑fluorophenyl‑acetone and benzoic acid analogues.
- In vitro effects: Potent monoamine release; high risk of neurotoxicity; no approved biomedical use.
- Research application: Toxicological screening standard, mass‑spectral reference, comparative SAR control.
Computational Chemistry
| Computed Parameter | B3LYP/6‑31G* Prediction |
|---|---|
| Dipole Moment | 2.9 Debye |
| HOMO–LUMO Gap | ~ 5.3 eV |
| Predicted log P | 2.6 – 2.8 |
| pKa (amine) | 9.8 |
| Topological Polar Surface Area | 27 Ų |
| Rotatable Bonds | 3 |
| Docking energy (hDAT) | ≈ –8.7 kcal · mol⁻¹ |
| Interpretation: Fluorine atom increases lipophilicity and dopamine transporter affinity via enhanced π–π interactions. |
Environmental Chemistry
- Hydrolysis: Slow; amine resistant to neutral hydrolysis.
- Photolysis: Degrades under UV to fluoro‑toluene and nitroso intermediates.
- Biodegradability: Limited; half‑life ≈ weeks in aerobic soil.
- Bioaccumulation Potential: Moderate (log Kow ≈ 2.7).
- Environmental Impact: Persistent micro‑pollutant risk if improperly disposed.
- Waste Management: Destroy via licensed high‑temperature incineration (> 1100 °C).
Laboratory Equipment
| Equipment | Recommended Use |
|---|---|
| GC‑MS (EI) | M⁺ = 167; major fragments = 44, 65, 135 m/z. |
| LC‑MS/MS | [M+H]⁺ = 168.118 m/z; quantitative for forensic screening. |
| FTIR | Characteristic peaks: 3360 cm⁻¹ (N–H stretch), 1510 cm⁻¹ C–F, 1475 cm⁻¹ aromatic C–C. |
| ¹H NMR (400 MHz) | δ 7.1 (Ar H), 2.8 (CH₂), 2.3 (N‑CH₃), 1.3 (CH₃). |
| Storage | Amber vial; dry inert gas environment; ≤ –20 °C; controlled access cabinet. |
Consumables
- Analytical‑grade methanol, acetonitrile, ammonium formate.
- PTFE syringe filters (0.2 µm).
- Glass autosampler vials (amber).
- Calibrated pipette tips, balance foils.
- Certified reference standards and lock‑spray tune solvents.
- Standard PPE: lab coat, nitrile gloves, eye protection, fume hood.
Regulation & Safety
| Category | Details |
|---|---|
| Controlled Status | Schedule I (US Analogue Act); Class A (UK Misuse of Drugs Act); Scheduled substance in EU and AU. |
| Permitted Use | Authorized forensic & chemical research under valid licence only. |
| GHS Hazard Codes | H301 (Toxic if swallowed), H331 (Toxic if inhaled), H370 (Causes organ damage). |
| Pictograms | ☠️ ⚠️ 🌡️ |
| Storage Protocol | Locked controlled substance safe, ambient humidity < 50 %. |
| Spill Procedure | Cover with activated carbon, collect as hazardous solid waste. |
| Disposal | Certified chemical destruction via licensed contractor. |
| Emergency First Aid | If exposure occurs – seek immediate medical attention; show container label. |
Chemical Informatics
| Identifier | Value |
|---|---|
| SMILES | CC(CC1=CC=C(F)C=C1)NC |
| InChIKey | FGYHXCVZJRCXNX‑UHFFFAOYSA‑N |
| CAS Registry No. | 101861‑37‑2 |
| Molecular Weight | 167.22 g · mol⁻¹ |
| log P | 2.7 (estimated) |
| TPSA | 27 Ų |
| Rotatable Bonds | 3 |
| Applications in informatics | Spectral database training · QSAR/QSPR model validation · LC‑MS forensic library entries. |
Regulatory & Ethical Notice
⚠️ Controlled Substance Disclaimer
4F‑MAR (4‑fluoromethamphetamine) is an illicit stimulant analogue regulated under international drug control conventions.
Possession, distribution, or synthesis outside licensed laboratories is illegal.
The data here are provided solely for chemical reference, forensic science, and educational purposes — not for human use, promotion, or sale.
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