Buy 4-FMA Pellets 100mg Online - (4‑Fluoromethamphetamine) — 100 mg Pellet Reference Standard
4‑Fluoromethamphetamine (Buy 4-FMA Pellets 100mg) is a para‑fluoro amphetamine analogue structurally related to methamphetamine.
Research uses include study of halogen‑substituted phenethylamines, metabolic oxidation pathways, and mass‑spectrometric calibration.
Organic / Inorganic Chemistry
| Property | Detail |
|---|---|
| IUPAC Name | 1‑(4‑fluorophenyl)‑N‑methylpropan‑2‑amine |
| Synonyms | 4‑FMA; para‑fluoromethamphetamine |
| Molecular Formula | C₁₀H₁₄FN |
| Molecular Weight | 167.22 g · mol⁻¹ |
| Physicochemical Form | Hydrochloride pellets (pressed powder, off‑white) |
| Melting Point (HCl) | ≈ 166 – 169 °C |
| Boiling Point (free base) | ≈ 210 °C (decomposes) |
| Solubility | Soluble in methanol, ethanol; partially soluble in water |
| Reactivity Profile | Stable when dry; amine oxidizes on exposure to light or air. |
Chemical Biology
- Classification: Aromatic fluoro‑substituted amphetamine derivative.
- Experimental relevance: Used to study monoamine release mechanisms and fluoro‑substituent effects on neurotransmitter transporters.
- Primary targets: Dopamine (DAT), norepinephrine (NET), and serotonin (SERT) transporters.
- Structure–activity summary: Fluorine shifts binding preference toward serotonergic system, reducing dopaminergic potency relative to methamphetamine.
- Metabolism observed: Oxidative dealkylation → 4‑fluorophenylacetone → acidic and phase II metabolites.
- Toxicological interest: Assessed for oxidative stress and cytotoxicity in neuronal cell models.
Computational Chemistry
| Parameter | Predicted Value (B3LYP/6‑31G*) |
|---|---|
| Dipole Moment | 2.43 D |
| HOMO–LUMO Gap | ≈ 6.0 eV |
| pKa (amine) | 9.9 |
| log P (pred.) | 2.4 ± 0.1 |
| Topological Polar Surface Area (TPSA) | 26 Ų |
| Rotatable Bonds | 3 |
| Predicted DAT‑binding energy | –9.1 kcal · mol⁻¹ |
| Note: Ring fluorination modifies electron distribution, affecting π–π interactions in binding sites. |
Environmental Chemistry
- Hydrolytic stability: Resists neutral hydrolysis; degrades slowly under acidic or alkaline conditions.
- Photolysis: Generates fluorinated acetophenone‑type products under UV exposure.
- Biodegradation: Moderate to slow (aerobic half‑life ≈ 7 ‑ 10 days).
- Mobility: Intermediate soil adsorption (Koc ≈ 280).
- Persistence: Fluoroaromatic moiety can persist in aquatic sediments.
- Waste disposal: Collect as hazardous amine compound; incinerate ≥ 1100 °C.
Laboratory Equipment
| Instrument | Analytical Utility |
|---|---|
| LC–MS/MS | [M+H]⁺ = 168 m/z; fragments 119 (benzyl ion) and 91 (tropylium). |
| GC–MS (EI) | M⁺ = 167 m/z with diagnostic ion 135 m/z. |
| FTIR (ATR) | C–F stretch ≈ 1130 cm⁻¹; amine N–H ≈ 3350 cm⁻¹; aromatic C=C ≈ 1600 cm⁻¹. |
| ¹H NMR (400 MHz) | δ 7.1–7.3 (aromatic), 2.9 (CH₂ N), 1.1 (CH₃). |
| Storage Conditions | ≤ –20 °C, light‑shielded, airtight container. |
Consumables
- LC‑MS‑grade solvents (methanol, water).
- Ammonium acetate mobile phase buffer (pH 3.5–4).
- Amber test vials to minimize UV degradation.
- PTFE syringe filters (0.22 µm).
- Analytical weigh boats and calibration standards.
- Personal protective equipment (P2 mask, nitrile gloves, safety goggles).
Regulation & Safety
| Category | Details |
|---|---|
| Controlled Status | Schedule I or Class A (amphetamine analogue) in most jurisdictions. |
| Permitted Use | Analytical calibration or forensic laboratory research only. |
| GHS Signal Word | Danger |
| Hazard Statements | H301 (Toxic if swallowed); H311 (Toxic in contact with skin); H370 (Causes organ damage). |
| Precautionary Notes | Handle in fume hood; avoid dust generation and inhalation. |
| First Aid | Flush exposure areas with water ≥ 15 minutes; seek medical attention immediately. |
| Spill Response | Absorb with activated charcoal or vermiculite; seal for incineration. |
Chemical Informatics
| Field | Information |
|---|---|
| SMILES | CC(CC1=CC=C(F)C=C1)NC |
| InChIKey | BMOUKADCBOSAKQ‑UHFFFAOYSA‑N |
| Molecular Mass | 167.22 g · mol⁻¹ |
| TPSA | 26 Ų |
| log P (predicted) | 2.4 |
| Rotatable Bonds | 3 |
| CAS (ref.) | 351‑03‑7 (varies by form) |
| Database Utility | MS/NMR reference library input, QSAR modelling, toxicokinetic simulation. |
Legal & Ethical Notice
⚠️ Controlled‑Substance Statement
4‑Fluoromethamphetamine is pharmacologically related to methamphetamine and is classified as a strictly controlled stimulant analogue under international law.
Handling is permitted only under license for research or analytical reference use.
The data above serve scientific and regulatory documentation purposes only and must not be interpreted as advertising or promotion.
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