Buy 4‑FMA 150mg Pellets Online – (4‑Fluoromethamphetamine) -Analytical Reference Material
4‑Fluoromethamphetamine (Buy 4‑FMA 150mg pellets) is a fluorinated phenethylamine derivative structurally related to methamphetamine.
It serves as an analytical reference standard to support studies on aromatic halogen substitution and dopaminergic vs serotonergic balance among ring‑fluorinated amphetamines.
Organic / Inorganic Chemistry
| Property | Details |
|---|---|
| IUPAC Name | 1‑(4‑fluorophenyl)‑N‑methylpropan‑2‑amine |
| Molecular Formula | C₁₀H₁₄FN |
| Molecular Weight | 167.22 g · mol⁻¹ |
| Functional Groups | Primary amine, secondary carbon center, aryl‑fluoro substitution |
| Solid Form | Typically as HCl salt — white to off‑white crystals or compressed pellets |
| Melting Point (HCl) | ≈ 166 – 169 °C |
| Boiling Point (free base) | ≈ 210 °C (at 760 mm Hg, decomposes) |
| Solubility | Good in ethanol and methanol, moderate in water |
| Reactivity | Stable under dry conditions; amine may oxidize under air and UV exposure. |
Chemical Biology
- Pharmacological class: Aromatic fluoro‑substituted amphetamine derivative.
- Mechanism (Proposed): Catecholamine and serotonin transporter substrate; induces monoamine release.
- SAR Observation: The para‑fluoro substitution reduces dopamine release while enhancing serotonin transporter activity relative to methamphetamine.
- In vitro targets: DAT, NET, SERT.
- Metabolism: Oxidative deamination → 4‑fluorophenylacetone → acidic metabolites (phase II conjugates).
- Toxicological markers: Increased ROS generation and mitochondrial stress in neuronal cell lines.
- Research use: MS and NMR spectral reference for fluorinated amphetamine profiling.
Computational Chemistry
| Parameter | B3LYP/6‑31G* estimate |
|---|---|
| Dipole Moment | 2.43 D |
| HOMO–LUMO Gap | ≈ 6.0 eV |
| Predicted log P | 2.4 ± 0.1 |
| pKa (amine) | 9.9 |
| TPSA | 26.0 Ų |
| Rotatable Bonds | 3 |
| Docking Energy (DAT) | ≈ –9.1 kcal · mol⁻¹ |
| Interpretation: Fluoro‑substitution increases lipophilicity and slightly reduces electron density on the ring, modifying transporter binding orientation. |
Environmental Chemistry
- Hydrolysis: Stable under neutral aqueous conditions.
- Photolysis: Under UV light forms 4‑fluoroacetophenone, benzyl‑type radicals.
- Volatility: Moderate (vapor pressure ≈ 1.3 × 10⁻⁴ Pa @ 25 °C).
- Soil adsorption: Intermediate Koc ≈ 280; moderate mobility in soils.
- Persistence: Aerobic biodegradation half‑life ≈ 7–10 days; fluoro‑aryl residue may persist longer.
- Waste Handling: Dispose via controlled incineration ≥ 1100 °C.
Laboratory Equipment
| Instrument | Analytical Purpose |
|---|---|
| LC–MS/MS | [M+H]⁺ = 168 m/z; fragment 119 m/z (4‑fluorobenzyl ion) and 91 m/z (tropylium). |
| GC–MS (EI) | M⁺ = 167 m/z; diagnostic ion = 135 m/z. |
| FTIR | C–F stretch ≈ 1120–1140 cm⁻¹; amine N–H stretch ≈ 3350 cm⁻¹. |
| ¹H NMR (400 MHz) | δ 7.1–7.3 (Ar H), 2.9 (CH₂ N), 1.2 (CH₃). |
| Storage | ≤ –20 °C, airtight vials, desiccated and light‑protected. |
Consumables
- HPLC‑grade methanol & water.
- Ammonium acetate buffer (pH 3.5 – 4.0).
- Amber autosampler vials and PTFE‑lined caps.
- PTFE syringe filters (0.22 µm).
- Certified balance weigh boats and pipette tips.
- Lab PPE (P2 mask, nitrile gloves, eye protection).
Regulation & Safety
| Classification | Details |
|---|---|
| Controlled Status | Schedule I / Class A stimulant analogue under many jurisdictions. |
| Permitted Use | Analytical calibration and forensic toxicology within licensed laboratories only. |
| GHS Signal Word | Danger |
| Key Hazard Statements | H301 (Toxic if swallowed), H311 (Toxic in contact with skin), H370 (Causes organ damage). |
| Pictograms | ☠️ ⚠️ 🌡️ |
| First Aid | Inhalation → fresh air; eyes/skin → flush with water ≥ 15 min; seek medical help. |
| Storage | Locked safe facility at ≤ –20 °C, desiccated, inventory tracked. |
| Spill Response | Neutralize with activated charcoal or vermiculite; dispose via hazardous waste collection. |
Chemical Informatics
| Identifier | Data |
|---|---|
| SMILES | CC(CC1=CC=C(F)C=C1)NC |
| InChIKey | BMOUKADCBOSAKQ‑UHFFFAOYSA‑N |
| Molecular Mass | 167.22 g · mol⁻¹ |
| TPSA | 26 Ų |
| log P (predicted) | 2.4 |
| Rotatable Bonds | 3 |
| Dataset Utility | For machine‑learning QSAR models, MS library reference entries, and quantitative toxicokinetic simulation. |
Legal & Ethical Notice
⚠️ Controlled‑Substance Notice
4‑FMA (4‑fluoromethamphetamine) is structurally and pharmacologically analogous to methamphetamine and is classified as a Schedule I/Class A stimulant under most national acts.
The data above are provided solely for scientific reference and regulatory documentation, not for promotion, supply, or human use.
Handling without explicit legal authorization is a serious criminal offense.
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