Buy 4F‑PIHP Powder Online – (4′‑Fluoro‑α‑pyrrolidinohexiophenone) — Analytical Reference Profile
Buy 4F‑PIHP Powder is a synthetic cathinone, structurally related to α‑PVP and 4F‑PVP, developed solely for forensic and toxicological research into psychoactive pyrrolidinophenone analogues.
It is handled as a fine crystalline powder or solid HCl salt reference, generally in sub‑gram analytical quantities.
Organic / Inorganic Chemistry
| Property | Details |
|---|---|
| IUPAC Name | 1‑(4‑Fluorophenyl)‑2‑(pyrrolidin‑1‑yl)‑1‑hexan‑1‑one |
| Chemical formula | C₁₆H₂₂FNO |
| Molecular mass | 263.35 g · mol⁻¹ |
| Structure type | Cathinone derivative (pyrrolidinophenone core) |
| Functional groups | Ketone (C=O), tertiary amine (pyrrolidine), fluoroaryl ring |
| Physical form | Off‑white to tan powder or crystals |
| Melting point | ≈ 95–97 °C (HCl salt) |
| Solubility | Soluble in methanol, acetonitrile; low in water |
| Reactivity | Degrades by oxidation when exposed to air or UV light |
Chemical Biology
- Pharmacological class: Synthetic cathinone stimulant analogue.
- Mechanistic insight: Predominantly dopamine and norepinephrine reuptake inhibitor in cell assays.
- Transporter affinity model: High DAT/NET selectivity, low SERT activity.
- Metabolic pathways: O‑dealkylation, reduction of ketone, and lactamization of pyrrolidine ring.
- In‑vitro toxicity: Cytotoxic at micromolar levels in neuronal cell lines.
- Human administration: Prohibited and potentially dangerous; no medical use approved.
Computational Chemistry
| Descriptor | Predicted (B3LYP/6‑31G*) |
|---|---|
| Dipole moment | 3.0 D |
| HOMO–LUMO gap | ≈ 5.1 eV |
| Pred. log P | 3.9 |
| TPSA | 29 Ų |
| Rotatable bonds | 6 |
| pKa (amine) | 10.2 |
| Docking energy (DAT) | ≈ –9.2 kcal mol⁻¹ |
| Use: QSAR model training for dopamine transporter ligands. |
Environmental Chemistry
- Fate: May hydrolyze slowly in alkaline conditions to β‑hydroxy and carboxylic products.
- Photolysis: Fluoroaryl moiety confers moderate UV stability.
- Biodegradability: Low — expected to persist in aquatic sediments.
- Bioaccumulation: Moderate potential (log Kow ≈ 3.8).
- Disposal: High‑temperature incineration (> 1000 °C) through licensed hazard waste channels.
Laboratory Equipment
| Equipment | Purpose |
|---|---|
| LC‑MS/MS | [M+H]⁺ = 264.175; fragment ions 245 and 126 m/z. |
| GC‑MS | M⁺ = 263; base peak 126 m/z from fluorophenyl moiety. |
| FTIR | 1705 cm⁻¹ (C=O), 1125 cm⁻¹ C–F stretch. |
| ¹H NMR | δ 7.0–7.4 ppm (aromatic), 3.1 ppm pyrrolidine CH₂, 1–1.5 ppm aliphatic. |
| Storage | ≤ –20 °C, light‑protected, locked controlled cabinet. |
Consumables
- HPLC‑grade methanol / acetonitrile / water.
- Formic acid (0.1 %) for positive‑ion electrospray MS.
- Syringe and membrane filters (0.22 µm PTFE).
- Amber autosampler vials to prevent UV degradation.
- Certified microbalances, calibrated pipettes, and reference standards.
- Mandatory PPE: nitrile gloves, safety glasses, lab coat, fume hood.
Regulation & Safety
| Category | Information |
|---|---|
| Legal class | Schedule I (U.S.), Class B (U.K.), Schedule 9 (Australia). |
| Permitted use | Analytical and forensic reference only under licence. |
| Hazard statements | H301 Toxic if swallowed; H331 Toxic if inhaled; H370 Causes organ damage. |
| GHS pictograms | ☠️ ⚠️ 🌡️ |
| Precautionary PPE | Respirator if powder dusting possible; biosafety cabinet handling. |
| Storage | Controlled substance safe with access logs. |
| Disposal | Incineration via permitholder hazard‑waste contractor. |
Chemical Informatics
| Identifier | Value |
|---|---|
| SMILES | CCCCCN(C1CCCC1)C(=O)C2=CC=C(F)C=C2 |
| InChIKey | YWJFHYYEUVTBGJ‑UHFFFAOYSA‑N |
| CAS Registry No. | 1427329‑25‑8 |
| Molecular weight | 263.35 g · mol⁻¹ |
| log P (pred.) | 3.86 |
| TPSA | 29.1 Ų |
| Rotatable bonds | 6 |
| Primary use | Structure‑activity relationship datasets and spectral libraries. |
Ethical & Legal Notice
⚠️ Controlled‑Substance Statement
4F‑PIHP is a controlled synthetic cathinone under national and UN psychotropic schedules.
Manufacture, possession, or distribution outside licensed research applications is illegal.
This report is for educational, forensic, and regulatory reference only and is not intended for marketing or consumption guidance.
Be the first to review “4f-Pihp Powder”
Related products
Research Chemicals
Research Chemicals
Research Chemicals
Research Chemicals
Research Chemicals
Research Chemicals
Research Chemicals
Research Chemicals
Reviews
There are no reviews yet.