4F-MPH Powder

Name: 4F-MPH Powder
SKU: 223
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€16

Price is per 0.5g

Category: Research Chemicals

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Buy 4F‑MPH Powder Online — Analytical Reference Material

Buy 4F‑MPH powder, or 4′‑fluoro‑methylphenidate, is a fluorinated derivative of methylphenidate intended solely for scientific analysis under appropriate regulatory control.
Its primary use in forensic chemistry is for structure–activity correlation, mass‑spectrometry calibration, and metabolism studies of substituted phenidate analogues.

Organic / Inorganic Chemistry

Property	Data
IUPAC Name	Methyl 2‑(4‑fluorophenyl)‑2‑(piperidin‑2‑yl)acetate
Formula	C₁₄H₁₈FNO₂
Molecular weight	251.30 g · mol⁻¹
Functional groups	Ester (C=O–O–CH₃), tertiary amine (piperidine), fluoro‑aryl ring
Molecular type	Halogenated phenidate (stimulant analogue class)
Physical form	Fine white to beige crystalline powder
Melting point (HCl salt)	≈ 191 °C
Solubility	Soluble in methanol and ethanol; sparingly soluble in water.
Chemical stability	Stable under dry, dark storage conditions ≤ 25 °C.

Chemical Biology

Pharmacological classification: Psychostimulant (research analogue only).
Mechanism of action: High‑affinity dopamine and norepinephrine reuptake inhibition, weaker serotonin interaction.
In vitro findings: ~3‑fold stronger DAT affinity compared with methylphenidate.
Research applications: Monoamine transporter binding assays, toxicological screening, neurotransmission modeling.
Metabolic transformations: Ester hydrolysis → 4‑fluoro‑ritalinic acid; oxidative dealkylation via CYP2D6 pathways.
Toxicology: Animal data indicate stimulant toxicity; human exposure is prohibited and unsafe.

Computational Chemistry

Descriptor	B3LYP/6‑31G* Prediction
Dipole moment	2.7 D
HOMO–LUMO gap	≈ 5.2 eV
Pred. log P	2.1
pKa (piperidine N)	8.6
TPSA	38 Å²
Rotatable bonds	4
Docking Energy (hDAT)	≈ –9.0 kcal · mol⁻¹
Computational use: QSAR development for dopamine‑transporter ligands and fluoro‑aryl SAR models.

Environmental Chemistry

Hydrolysis: Slow in neutral aqueous phase; accelerated in alkaline conditions.
Photostability: Moderate — UV exposure causes fluoro‑phenol by‑products.
Biodegradability: Poor; may persist and adsorb to organic matter.
Bioaccumulation potential: Moderate (log Kow ≈ 2.1).
Waste disposal: Oxidative digestion or licensed high‑temperature incineration only.
Environmental concern: Persistent organic micro‑pollutant potential if mismanaged.

Laboratory Equipment

Instrumentation	Purpose
HPLC / LC‑MS/MS	Detection of [M+H]⁺ = 252.134 m/z and characteristic fragment ions 84 and 234.
GC‑MS	M⁺ = 251; base peak at 84 (piperidine fragment).
FTIR	1730 cm⁻¹ (C=O), 1240 cm⁻¹ C–O–C, 1100 cm⁻¹ C–F stretch.
NMR (¹H)	δ 7.2 (Ar 4H), 4.1 (CH–COOCH₃), 2.3 (piperidine CH₂), 3.6 (OCH₃).
Melting point test	Capillary method at controlled rate 1 °C ∕ min.
Storage	Sealed amber vials; –20 °C; inert atmosphere; controlled access.

Consumables

- HPLC‑grade methanol / acetonitrile / water.
- Formic acid (0.1 %) mobile phase modifier.
- PTFE syringe filters (0.22 µm).
- Amber autosampler vials, pipette tips, analytical weighing paper.
- Certified micropipettes and balances (0.1 mg accuracy).
- PPE: gloves (nitrile), lab coat, goggles, fume hood usage.

Regulation & Safety

Category	Information
Legal status	Schedule I analogue (USA); Class B (UK Psychoactive Act); controlled EU NPS listing.
Permitted use	Forensic / chemical research under appropriate licence only.
GHS hazard code	H301 Toxic if swallowed · H331 Toxic if inhaled · H370 Causes organ damage.
Pictograms	☠️  ⚠️  🌡️
Storage	Controlled substance safe · dark · dry · ≤ –20 °C.
Spill procedure	Absorb on activated carbon; bag for hazard waste removal.
Disposal	Certified hazardous chemical waste incineration (> 1100 °C).

Chemical Informatics

Identifier	Value
SMILES	`COC(=O)C(C1CCCCN1)C2=CC=C(F)C=C2`
InChIKey	`VIGXNXDNAOHARM‑UHFFFAOYSA‑N`
CAS Registry No.	1354631‑73‑0
Molecular weight	251.30 g · mol⁻¹
log P (calc.)	2.05
TPSA	38.0 Å²
Rotatable bonds	4
Primary application	Spectral library reference and QSAR database training set component.

Ethical & Legal Notice

⚠️ Controlled‑Substance Disclaimer
4F‑MPH (4′‑fluoro‑methylphenidate) is a restricted stimulant analog governed by the U.S. Federal Analogue Act, UN Psychotropic Substances Schedules, and various national drug control laws.
Possession, production, or distribution outside licensed research violates criminal law.
The data above are presented solely for regulatory, forensic, and educational reference, not for promotion or consumption guidance.