5‑MeO‑MiPT 15mg Pellets – (5‑Methoxy‑N‑methyl‑N‑isopropyltryptamine) — Analytical & Regulatory Overview
5‑MeO‑MiPT 15mg Pellets is a synthetic indole‑alkylamine belonging to the tryptamine class.
It has been identified in “research chemical” samples formatted as tablets or pellets (e.g., nominal 15 mg each), intended for unregulated use before scheduling.
All such materials are now prohibited substances, controlled under Schedule I (US) and Class A (UK) law.
Organic / Inorganic Chemistry
| Property | Description |
|---|---|
| IUPAC name | N‑[2 ‑(5‑methoxy‑1H‑indol‑3‑yl) ethyl] ‑ N‑methylpropan‑2‑amine |
| Empirical formula | C₁₅H₂₂N₂O |
| Molar mass | 246.35 g · mol⁻¹ |
| Functional groups | Indole ring, secondary amine (N‑methyl‑N‑isopropyl), methoxy ether. |
| Physical form | Crystalline solid (white–beige). |
| Solubility | Freely soluble in methanol, ethanol, or chloroform. |
| Salt form used | Commonly hydrochloride or fumarate for analytical reference. |
Chemical Biology
- Mechanism: Agonist activity at 5‑HT₁A and 5‑HT₂A/2C receptors.
- Metabolism: O‑demethylation → 5‑HO‑MiPT; oxidative de‑amination via MAO.
- Pharmacology: Produces psychoactive mind‑altering effects; no approved medical indication.
- Toxicology: Limited data; potential CNS over‑stimulation and hyperthermia.
Computational Chemistry
| Descriptor | Typical Value |
|---|---|
| HOMO‑LUMO gap | ≈ 4.6 eV |
| Dipole moment | 2.5 D |
| Pred. log P | 2.9 |
| Polar surface area | 42 Ų |
| Rotatable bonds | 5 |
| Cytochrome P450 binding (virtual) | Predicted CYP2D6 substrate likelihood > 0.7 |
| QSAR applications | Used for indole family structure‑activity studies. |
Environmental Chemistry
- Degradation: Photolysis and oxidation to indole‑2‑ones and methoxyphenols.
- Bioaccumulation factor: Low (moderate lipophilicity and rapid oxidation).
- Persistence: Decomposes slowly in neutral soil at ambient temperatures.
- Disposal: High‑temperature combustion (≥ 1000 °C) in licensed facility.
Laboratory Equipment (for licensed analysis)
| Instrument | Purpose |
|---|---|
| GC‑MS (EI) | Screening and identification — base ion m/z 58. |
| LC‑QTOF‑MS | High‑resolution confirmation [M+H]⁺ = 247.1802. |
| ¹H‑NMR | Methyl resonances ~1.2 ppm; aromatic protons 6.8–7.5 ppm. |
| FTIR | N–H stretch ≈ 3330 cm⁻¹; C–O ≈ 1250 cm⁻¹. |
| UV–Vis | λₘₐₓ ~ 278 nm (aromatic π→π*). |
Facility requirements: DEA/Home Office research licence, Class II fume hood, trace‑quantity balances.
Consumables
- LC‑grade acetonitrile / water + 0.1 % formic acid.
- Amber autosampler vials (PTFE liners).
- 0.22 µm PTFE syringe filters.
- Reference standard solutions (≤ 1 mg · mL⁻¹ under licence).
- Nitrile gloves, safety glasses, lab coats.
Regulation & Safety
| Category | Details |
|---|---|
| Controlled status | Schedule I (US Controlled Substances Act); Class A (Psychoactive Substances Act UK). |
| Permitted use | Forensic and scientific research in approved facilities only. |
| GHS classification | H301 (Toxic if swallowed) · H331 (Toxic if inhaled) · H370 (Target‑organ toxicant). |
| Handling precautions | Avoid dust; use local exhaust ventilation and PPE. |
| Storage | ≤ –20 °C, protected from light, in locked controlled‑substance safe. |
| Waste | Incineration with acid gas scrubbing; document chain of custody. |
Chemical Informatics
| Descriptor | Representative Value |
|---|---|
| SMILES | CC(C)N(C)CCC1=CNC2=CC=C(OC)C=C12 |
| InChIKey | CHZVERDGACCTDJ‑UHFFFAOYSA‑N |
| Molecular weight | 246.35 g mol⁻¹ |
| log P | 2.9 |
| TPSA | 42 Ų |
| Rotatable bonds | 5 |
| Applications | Forensic mass‑spectral libraries; QSAR training sets for serotonergic ligands. |
Ethical and Legal Notice
⚠️ Controlled‑Substance Advisory
5‑MeO‑MiPT is an internationally scheduled psychedelic compound.
Its manufacture, distribution, or possession is illegal without explicit research authorization.
This document serves only as a scientific and regulatory reference for chemical and forensic professionals.




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