Buy 4‑HO‑MiPT 20mg Pellets Online – (4‑Hydroxy‑N‑methyl‑N‑isopropyltryptamine) — Analytical Reference Material
Buy 4‑HO‑MiPT 20mg pellets is the 4‑hydroxy analogue of MiPT (N‑methyl‑N‑isopropyltryptamine) and closely related to psilocin (4‑HO‑DMT).
It is studied within controlled laboratories to investigate:
- Serotonin‑receptor binding and structure–activity relationships (SAR) of tertiary tryptamines.
- In‑vitro metabolic pathways, enzymatic dephosphorylation, and detoxification mechanisms.
- Spectral calibration in LC–MS/MS and FTIR assays for psychedelic substance identification.
Organic / Inorganic Chemistry
| Property | Details |
|---|---|
| IUPAC Name | 3‑(2‑(isopropyl(methyl)amino)ethyl)‑1H‑indol‑4‑ol |
| Formula | C₁₄H₂₀N₂O |
| Molecular Weight | 232.33 g · mol⁻¹ |
| Functional Groups | Phenolic (4‑OH), indole, secondary amine, isopropyl moiety |
| Physical Form | White to light‑tan crystalline solid (fumarate salt) |
| Melting Point (fumarate) | ≈ 156 – 158 °C |
| Solubility | Soluble in alcohols and chloroform; low in water |
| Reactivity | Prone to oxidation in air and UV light; protection under nitrogen recommended. |
Chemical Biology
- Pharmacological class: Tryptamine serotonergic agonist.
- Mechanism: Partial agonism at 5‑HT₂A and 5‑HT₁A receptors.
- SAR notes: The isopropyl substituent increases lipophilicity and molecular volume, producing slightly stronger 5‑HT₂A binding (approx. –10.1 kcal mol⁻¹ vs –9.7 for 4‑HO‑DMT).
- Metabolism: Monoamine oxidase deamination → 4‑hydroxyindol‑3‑acetaldehyde → acidic metabolites and glucuronides.
- In‑vitro index: Cytotoxicity low at micromolar range; non‑mutagenic per Ames test models.
- Analytical function: Mass‑spectral reference for tryptamine screening and receptor model training.
Computational Chemistry
| Parameter | DFT (B3LYP/6‑31G*) Value |
|---|---|
| Dipole Moment | 3.0 Debye |
| HOMO–LUMO Gap | ≈ 5.5 eV |
| Predicted log P | 2.0–2.2 |
| pKa (amine N) | 9.7 |
| TPSA | 54 Ų |
| Rotatable Bonds | 5 |
| Docking Energy (5‑HT₂A) | ≈ –10.1 kcal · mol⁻¹ |
| Interpretation: Isopropyl bulk induces a rotational constraint that aligns the amine nitrogen favorably for π‑stacking with Trp336 in the 5‑HT₂A binding site. |
Environmental Chemistry
- Hydrolysis: Stable at neutral pH; decomposes fast under acidic or basic conditions.
- Photodegradation: Indole oxidizes to quinone species under UV.
- Biodegradability: Moderate (half‑life ≈ 9 days, aerobic).
- Soil adsorption: Intermediate Koc value (~360).
- Waste treatment: Classified as hazardous organic amine; dispose via high‑temperature incineration only.
Laboratory Equipment
| Instrument | Analytical Use / Data |
|---|---|
| LC–MS/MS | [M+H]⁺ = 233.164 m/z; fragment at 174 and 160 m/z. |
| GC–MS (EI) | M⁺ = 232 m/z; derivatization recommended for volatility. |
| FTIR | Broad O–H (3400 cm⁻¹), C=C (1620 cm⁻¹), C–N (1220 cm⁻¹). |
| ¹H NMR (400 MHz) | δ 7.0–7.2 (aromatic H), 3.0–3.6 (CH₂N), 1.1–1.3 (isopropyl CH₃). |
| Safety Equipment | Category‑3 fume hood, nitrile gloves, eye protection, anti‑static handling tools. |
Consumables
- LC‑MS‑grade methanol and water.
- Ammonium‑formate buffer (0.01 M, pH 3.5).
- Amber autosampler vials to limit UV oxidation.
- PTFE syringe filters (0.22 µm).
- Cryogenic tubes for low‑temp storage.
- PPE: nitrile gloves, lab coat, goggles.
Regulation & Safety
| Category | Information |
|---|---|
| Controlled Status | Schedule I / Class A psychedelic analogue in most jurisdictions. |
| Permitted Use | Licensed analytical and forensic research only. |
| GHS Signal Word | Danger |
| GHS Hazards | H301 (Toxic if swallowed) • H311 (Toxic in contact with skin) • H370 (Causes organ damage). |
| Pictograms | ☠️ ⚠️ 🌡️ |
| Storage | Light‑resistant vial, ≤ –20 °C, locked facility. |
| First Aid | Inhalation → Fresh air; Skin/Eye → Rinse 15 min; Seek medical help. |
| Spill Response | Inert absorbent (vermiculite); dispose to hazardous waste. |
Chemical Informatics
| Identifier | Value |
|---|---|
| SMILES | CC(C)N(C)CCc1c[nH]c2cccc(O)c12 |
| InChIKey | PZGUSPAORZZJGE‑UHFFFAOYSA‑N |
| Molecular Mass | 232.33 g · mol⁻¹ |
| TPSA | 54 Ų |
| Rotatable Bonds | 5 |
| Predicted log P | 2.1 |
| CAS Number | 96096‑55‑8 |
| Typical Applications | QSAR/QSPR dataset training, AI molecular descriptors, as a reference spectrum in LC–MS libraries. |
Legal & Ethical Notice
⚠️ Controlled‑Substance Notice
4‑HO‑MiPT is a controlled psychedelic tryptamine analogue in most countries (worldwide Schedule I equivalent).
This information is provided only for licensed research, forensic toxicology, and chemical‑informatics documentation.
It must not be used to advertise, promote, or distribute the compound outside of legal contexts.
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