Buy 4‑HO‑MET 20mg Pellets Online – (4‑Hydroxy‑N‑methyl‑N‑ethyltryptamine) — Analytical Reference Standard
Buy 4‑HO‑MET 20mg pellets is a structural analogue of psilocin (4‑HO‑DMT) and belongs to the indole‑based tryptamine family.
It is typically prepared as a fumarate or hydrochloride salt and used in forensic toxicology or receptor‑binding simulation studies.
Researchers investigate how side‑chain substitutions (ethyl vs dimethyl) affect serotonin receptor interactions and metabolism.
Organic / Inorganic Chemistry – Buy 4‑HO‑MET 20mg Pellets
| Property | Details |
|---|---|
| IUPAC Name | 3‑(2‑(ethyl(methyl)amino)ethyl)‑1H‑indol‑4‑ol |
| Molecular Formula | C₁₃H₁₈N₂O |
| Molecular Weight | 218.30 g · mol⁻¹ |
| Functional Groups | Secondary amine, indolic aromatic ring, phenolic hydroxyl, ethyl alkyl substituent |
| Physical Form | Off‑white to beige crystalline solid (salt form) |
| Melting Point (fumarate) | ≈ 148–150 °C |
| Solubility | Freely soluble in methanol, ethanol, chloroform; limited in water |
| Stability | Sensitive to oxidation and UV light; store cold and inert atmosphere (< –20 °C). |
Chemical Biology
- Pharmacological class: Tryptamine serotonergic agonist.
- Mechanism of action: Partial agonism at 5‑HT₂A/2C and 5‑HT₁A receptors; minimal dopaminergic activity.
- SAR Observation: Ethyl substitution on the amine increases hydrophobic interaction energy (~0.3 kcal mol⁻¹ more than psilocin).
- Metabolism: Likely phase I oxidative deamination and glucuronidation of the 4‑hydroxy group.
- Laboratory use: Spectral reference for MS libraries and QSAR studies of indole derivatives.
- Toxicological note: Low acute in‑vitro cytotoxicity but considered Class A psychedelic risk compound.
Computational Chemistry
| Parameter | B3LYP/6‑31G* Estimate |
|---|---|
| Dipole Moment | 3.1 Debye |
| HOMO–LUMO Gap | ≈ 5.7 eV |
| Predicted log P | 1.7–1.9 |
| pKa | 9.9 (amino group) / 10.1 (phenolic OH) |
| TPSA | 54 Ų |
| Rotatable Bonds | 5 |
| Docking Energy (5‑HT₂A) | ≈ –9.6 kcal · mol⁻¹ |
| Interpretation: The 4‑hydroxyl bonding and ethyl‑methyl amine moiety adjust π‑stacking geometry within the indole pocket differently than psilocin. |
Environmental Chemistry
- Hydrolysis: Stable under neutral pH; degrades in strong acidic media.
- Photodegradation: Produces indole‑quinone derivatives upon UV exposure.
- Biodegradability: Moderate; natural microbial enzymes can oxidize indole groups over weeks.
- Waste Code: Hazardous organic amine category.
- Waste Treatment: Controlled incineration (≥ 1100 °C) under licensed protocols.
- Environmental Impact: Trace aromatic amines are aqueous toxins at < µg/L levels; avoid drain discharge.
Laboratory Equipment
| Instrument | Use |
|---|---|
| LC‑MS/MS | [M+H]⁺ = 219.149 m/z; dominant fragment 160 m/z (indole break). |
| GC–MS (EI) | M⁺ = 218 m/z; chromatographic derivatization often required. |
| FTIR | Broad 3400 cm⁻¹ (–OH), 1620 cm⁻¹ (indole C=C), 1220 cm⁻¹ (C–N). |
| UV‑Vis | λₘₐₓ ≈ 278 nm (indole π→π* transition). |
| NMR (¹H, 400 MHz) | δ 7.0–7.3 (aromatic H), 2.8–3.5 (CH₂N), 1.0–1.2 (ethyl CH₃). |
| Storage | Light‑protected glass vials, nitrogen flushed, ≤ –20 °C. |
Consumables
- HPLC‑grade methanol & water
- Ammonium‑formate buffer (5 mM, pH 3.5)
- Amber autosampler vials to reduce UV oxidation
- PTFE syringe filters (0.22 µm)
- Analytical weighing boats and pipette tips
- PPE: nitrile gloves, spectacles, lab coat, fume‑hood operations mandatory
Regulation & Safety
| Classification | Information |
|---|---|
| Controlled Status | Often listed with psilocin and its analogues (Class A / Schedule I substance). |
| Permitted Use | Analytical reference and forensic toxicology under controlled‑drug licenses. |
| GHS Hazards | H301 (Toxic if swallowed) • H317 (May cause allergic skin reaction) • H370 (Causes organ damage). |
| Pictograms | ☠️ ⚠️ 🌡️ |
| Precautions | Do not inhale dust or vapor; avoid oxidation sources; use grounded equipment. |
| First Aid | Rinse affected areas with water ≥ 15 min; seek medical attention. |
| Storage | Locked safe under cool dry conditions; inventory log per local authority rules. |
| Disposal | Transfer to licensed hazardous waste incinerator only. |
Chemical Informatics
| Identifier | Data |
|---|---|
| SMILES | CCN(C)CCc1c[nH]c2cccc(O)c12 |
| InChIKey | ZCFFVIDGUGUKLB‑UHFFFAOYSA‑N |
| Molecular Weight | 218.30 g · mol⁻¹ |
| TPSA | 54 Ų |
| Rotatable Bonds | 5 |
| Predicted log P | 1.8 |
| CAS Number | 122760‑83‑8 |
| Database Application | Molecular descriptor generation, psychedelic SAR modelling, and MS spectral reference entries. |
Legal & Ethical Statement
⚠️ Controlled Substance Notice
4‑HO‑MET is analogous to psilocin and is regulated under Schedule I / Class A acts in most jurisdictions.
This document serves only for chemical informatics, toxicology, and forensic education within licensed research entities.
Its production, distribution, or use outside authorized laboratories is illegal and punishable under drug‑control laws.
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