Buy 3‑MMA Powder Online — Analytical Reference Standard
Buy 3‑MMA powder (3‑methyl‑N‑methyl‑1‑phenylpropan‑2‑amine) is a structural analogue of methamphetamine, distinguished by a methyl substitution at the meta position of the phenyl ring.
Its analytical relevance lies in comparative chromatographic, spectroscopic, and QSAR analysis within amphetamine series research, as well as forensic method validation.
Organic / Inorganic Chemistry
| Property | Information |
|---|---|
| IUPAC Name | N‑methyl‑1‑(3‑methylphenyl)propan‑2‑amine |
| Molecular Formula | C₁₁H₁₇N |
| Molecular Weight | 163.26 g · mol⁻¹ |
| Chemical Class | Substituted phenethylamine / amphetamine derivative |
| Functional Groups | Secondary amine, aromatic ring, alkyl substituents |
| Appearance | White to off‑white crystalline powder (HCl salt) |
| Melting Point | ≈ 172 – 175 °C (HCl salt) |
| Solubility | Freely soluble in water, ethanol, and isopropanol |
| Stability | Stable under dry, anoxic conditions; oxidatively sensitive in light or moist air. |
Chemical Biology
- Pharmacological classification: Stimulant amine analog acting as monoamine transporter substrate (DAT, SERT, NET).
- Structure–Activity Rationale: 3‑methyl substitution modifies π‑electron density of the phenyl ring, reducing SERT affinity compared with para analogues.
- Metabolism (in vitro): Aromatic hydroxylation (ω‑1), N‑demethylation, and β‑hydroxylation yielding 3‑hydroxymethylamphetamine analogs.
- Research use: Method validation and forensic comparison with amphetamine isomers via GC–MS and LC–MS.
Computational Chemistry
| Descriptor | Predicted Value (DFT B3LYP/6‑31G*) |
|---|---|
| Dipole Moment | 2.72 D |
| HOMO–LUMO Gap | 6.5 eV |
| log P (pred.) | 2.4 ± 0.2 |
| pKa (amine) | 9.8 |
| TPSA | 26 Ų |
| Rotatable Bonds | 3 |
| Docking Energy (DAT) | ≈ –9.1 kcal · mol⁻¹ |
| Computational Summary: The meta‑methyl group alters the rotational freedom and affects binding orientation at the dopamine transporter, reducing potency relative to methamphetamine. |
Environmental Chemistry
- Hydrolysis Stability: Stable at neutral pH; amine degradation under strong oxidizing conditions.
- Photolysis: Forms aromatic ketones and amine oxides.
- Biodegradability: Moderate; amine group readily oxidized by soil bacteria.
- Bioaccumulation Potential: Low (log Kow ≈ 2.4).
- Disposal: Oxidative neutralization or licensed hazardous organic waste incineration (>1100 °C).
Laboratory Equipment
| Method | Analytical Use |
|---|---|
| GC–MS (EI 70 eV) | M⁺ = 163 m/z; key ions 58 (amine fragment), 91 (tropylium ion). |
| LC–MS/MS | [M+H]⁺ = 164 m/z; fragment → 119 m/z (benzyl cation). |
| FTIR (ATR) | N–H stretch ≈ 3360 cm⁻¹; C–H aromatic ≈ 3040 cm⁻¹; C–N ≈ 1250 cm⁻¹. |
| ¹H NMR (400 MHz) | δ 7.1 (Ar H), 2.9 (CH–NH CH₃), 2.2 (Ar–CH₃), 1.25 (CH₃ amine). |
| Storage Conditions | Dry, dark, cool (≤ –20 °C), in sealed amber vials. |
Consumables
- HPLC grade methanol and acetonitrile.
- Formic acid or ammonium formate buffers for mobile phases.
- Amber autosampler vials (1.5 mL PTFE‑lined caps).
- Analytical balances (± 0.1 mg) with antistatic shielding.
- PPE: lab coat, nitrile gloves, chemical goggles, respiratory mask when powders weighing.
Regulation & Safety
| Aspect | Information |
|---|---|
| Controlled Status | Schedule I (US CSA); Class A or B (UK and EU equivalents). |
| Permitted Use | Toxicological or forensic reference material under license. |
| GHS Signal Word | Danger |
| Hazard Statements | H301: Toxic if swallowed; H331: Toxic if inhaled; H370: Causes damage to organs. |
| Precautions | Handle in chemical fume hood, minimize dust formation; keep under secure lock and inventory. |
| First Aid | Flush contact areas with water ≥ 15 min; seek medical attention immediately. |
| Waste Disposal | Collect in designated secondary amine organic waste container → licensed destruction. |
Chemical Informatics
| Field | Data |
|---|---|
| SMILES | CC(C)NC(C)C1=CC(=CC=C1)C |
| InChIKey | CBFUGKOSCCXHGV‑UHFFFAOYSA‑N |
| Molecular Weight | 163.26 g · mol⁻¹ |
| TPSA | 26 Ų |
| log P | 2.4 |
| Rotatable Bonds | 3 |
| CAS Ref. No. | (Analogue group designation: Not unique in CAS registry due to scheduling.) |
| Applications | Spectral libraries, forensic data comparison, SAR/QSAR model benchmarking. |
Legal & Ethical Notice
⚠️ Controlled‑Substance Statement
3‑Methylmethamphetamine (3‑MMA) is classified as a Schedule I controlled amphetamine derivative.
Possession, synthesis, use, or distribution is restricted to licensed and authorized facilities for analytical or regulatory purposes only.
This information is provided solely for scientific documentation, compliance, and education — not for promotion, sale, or human use.
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