Buy 3‑FA Powder Online — Analytical Reference Material
3‑Fluoroamphetamine (Buy 3‑FA powder) is a fluorinated analogue of amphetamine, belonging to the phenethylamine stimulant class.
It serves as a forensic reference compound and LC–MS/MS calibration standard for the identification and classification of halogenated amphetamine isomers in controlled‑substance analysis.
The powder form allows precise micro‑weighing, sample spiking, and mass spectral reference creation in authorized research settings.
Organic / Inorganic Chemistry
| Property | Description |
|---|---|
| IUPAC Name | 1‑(3‑fluorophenyl)propan‑2‑amine |
| Molecular Formula | C₉H₁₂FN |
| Molecular Weight | 153.20 g mol⁻¹ |
| Chemical Class | Halogenated amphetamine derivative |
| Functional Groups | Primary amine, aromatic fluoro ring |
| Physical Appearance | Fine white to off‑white powder |
| Melting Point (HCl) | ≈ 156 – 160 °C |
| Boiling Point (free base) | ≈ 203 °C (decomposes) |
| Solubility | Freely soluble in methanol, acetonitrile; sparingly soluble in water. |
| Stability | Stable under dry, dark, sealed conditions. Sensitive to light and oxidation. |
Chemical Biology
- Pharmacological Class: Amphetamine‑type stimulant analogue.
- Research Applications: Used to test mass spectrometry methods for fluoro‑substituted amphetamines and to calibrate transport assays.
- Biochemical Behavior: Acts as a monoamine releasing agent in vitro (primarily dopamine and norepinephrine pathways).
- Metabolism (in vitro): N‑deamination, β‑hydroxylation, aromatic fluoro ring hydroxylation, and phase II conjugation.
- Enzymatic Stability: Fluoro‑substitution reduces oxidation by CYP2D6 and extends metabolic half‑life in cell culture.
Computational Chemistry
| Descriptor | Value (B3LYP/6‑31G*) |
|---|---|
| Dipole Moment | 2.70 D |
| HOMO‑LUMO Gap | 6.3 eV |
| log P (pred.) | 2.3 |
| pKa (amine) | 9.8 |
| TPSA | 26 Ų |
| Rotatable Bonds | 3 |
| Docking Affinity (DAT) | ~ –8.0 kcal mol⁻¹ |
| Commentary: Fluoro‑substitution at the meta‑position modifies electrostatic distribution, altering binding orientation vs non‑halogenated amphetamine. |
Environmental Chemistry
- Aqueous Persistence: Slowly degrades under neutral‑pH conditions.
- Photostability: Moderate decay rate under UV light (280–320 nm).
- Biodegradability: Limited; fluorinated ring is resistant to microbial oxidation.
- Bioaccumulation Potential: Moderate (log Kow ≈ 2.3).
- Waste Treatment: Perform oxidative destruction (e.g., KMnO₄ or NaOCl), then incinerate > 1100 °C under licensed conditions.
Laboratory Equipment
| Instrument | Analytical Use |
|---|---|
| LC–MS/MS | [M+H]⁺ = 154 m/z ; fragments 136 m/z, 119 m/z. |
| GC–MS (EI) | M⁺ = 153 m/z ; base peak 44 (methylamine fragment). |
| FTIR (ATR) | Bands: N–H ≈ 3340 cm⁻¹, C–F ≈ 1220 cm⁻¹, C–N ≈ 1130 cm⁻¹. |
| ¹H NMR (400 MHz) | δ 7.0–7.4 (aromatic H), 2.9–3.2 (CH₂‑NH₂ region). |
| Elemental Analysis | C ≈ 70.6 %; H ≈ 7.9 %; N ≈ 9.1 %; F ≈ 12.3 %. |
| Storage | Store at –20 °C, in airtight, light‑protected glass or PTFE vial. |
Consumables
- LC‑grade methanol and acetonitrile.
- Formic acid (0.1 %) and ultrapure water for mobile phases.
- Amber vials with PTFE/silicone septa to minimize volatilization.
- Antistatic polymer weighing boats and microspatulas.
- PPE: nitrile gloves, lab coat, protective eyewear, and fume hood use.
Regulation & Safety
| Aspect | Information |
|---|---|
| Controlled Status | Schedule I (United States, Analogue Act) • Class B (UK MDA 1971) • Schedule 9 (Australia). |
| Permitted Use | Authorized forensic and analytical laboratories only. |
| GHS Signal Word | Danger |
| Hazard Phrases | H301 Toxic if swallowed • H311 Toxic in contact with skin • H331 Toxic if inhaled. |
| Precautionary Statements | Avoid dust generation; wear PPE; operate in ventilated hood. |
| First Aid | Flush contact areas ≥ 15 min; seek medical attention immediately. |
| Waste Disposal | Dispose through licensed hazardous‑waste facility. |
Chemical Informatics
| Field | Data |
|---|---|
| SMILES | CC(CC1=CC(=CC=C1F))N |
| InChIKey | QXOWNYVXYZVGXQ‑UHFFFAOYSA‑N |
| Formula Mass | 153.20 g mol⁻¹ |
| TPSA | 26 Ų |
| log P | 2.3 |
| Rotatable Bonds | 3 |
| CAS Registry | Not officially listed (substance analog identifier used internally). |
| Applications | Reference for MS libraries and computational SAR/QSAR training datasets. |
Legal & Ethical Notice
⚠️ Controlled‑Substance Guidance
3‑Fluoroamphetamine is a regulated amphetamine analogue. Possession,
distribution, or research outside licensed facilities is prohibited.
This document is intended for scientific education and regulatory recordkeeping only and is not to be used for promotion or commercial marketing.
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