Bromonordiazepam Powder

Buy Bromonordiazepam Powder Online — High‑Purity Analytical Reference Material

Overview

Buy Bromonordiazepam Powder (7‑Bromo‑5‑phenyl‑1,3‑dihydro‑1,4‑benzodiazepin‑2‑one) is a halogenated benzodiazepine derivative used as a research‑grade analytical reference in forensic chemistry, spectroscopy, and molecular simulation studies.
The crystalline powder form ensures versatility across thermal analysis, purity testing, chromatographic calibration, and computational modeling.
Each batch is prepared under ISO 9001 and GLP‑compliant conditions, providing a purity of ≥ 99.0 % (by HPLC) and reproducible physicochemical properties.

⚠️ For laboratory, research, and analytical use only. Not approved for human or veterinary use.

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Chemical Identity

• Chemical Name: 7‑Bromo‑5‑phenyl‑1,3‑dihydro‑1,4‑benzodiazepin‑2‑one
• Common Names / Synonyms: Bromonordiazepam | Norflurazepam | Desalkylflurazepam
• Chemical Class: Halogenated benzodiazepine / Aryl amide compound
• Molecular Formula: C15H10BrN2O
• Molecular Weight: 329.16 g/mol
• CAS No.: 28910‑91‑0
• Purity: ≥ 99 % (HPLC Validated)
• Form: Crystalline powder
• Solubility: Slightly soluble in ethanol and methanol; insoluble in water
• Appearance: White to pale beige powder
• Melting Range: Approximately 240 °C (decomposition)

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Applications Across Chemistry Disciplines

Organic & Inorganic Chemistry

• Demonstrates both amide (–CONH–) and aromatic domains, suitable for amide hydrolysis, electrophilic substitution, and halogen‑exchange studies.
• Serves as a model compound in C‑Br bond dissociation kinetics and organometallic coupling reaction research (e.g., Suzuki and Stille couplings).
• Used for heterocyclic ring behavior analysis, studying lactam carbonyl reactivity in aromatic heterocycles.
• Engages with transition metals (Pd, Ni, Cu) in computational and in vitro complexation studies.

Chemical Biology

• Reference molecule for receptor‑binding and ligand interaction simulation in biochemical modeling environments.
• Employed in non‑biological enzyme pathway assays to analyze oxidative metabolism reaction kinetics.
• Used to benchmark lipophilicity, membrane diffusion, and pH‑dependent tautomeric equilibrium in silico.
• Provides a realistic scaffold for amide‑based inhibitor design without biological activity.

Computational Chemistry

• Benchmark system for Density Functional Theory (DFT) and ab initio simulations assessing charge distribution and polar resonance.
• Evaluated in Molecular Dynamics (MD) environments for hydrogen bond networks and π–π stacking stability.
• Contributes to QSAR/QSPR modeling datasets focusing on electronic polarizability, HOMO–LUMO gap, and dipole moment distribution.
• Serves as a template in quantum mechanics / molecular mechanics (QM/MM) hybrid model comparisons.

Environmental Chemistry

• Applied as a reference standard for LC–MS/MS traces of benzodiazepine metabolites in wastewater and surface water matrices.
• Assists in environmental risk modeling for halogenated organics and recalcitrant nitrogen heterocycles.
• Provides data on biodegradation, photolysis, and hydrolytic persistence rates of N–Br organic compounds.
• Utilized to establish mass spectral libraries for environmental monitoring and forensic toxicology.

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Laboratory Equipment & Consumables

Recommended Instruments

• High‑Performance Liquid Chromatography (HPLC) – Purity verification and retention time analysis
• Gas Chromatography–Mass Spectrometry (GC–MS) – Volatile fragment profile and thermolysis identification
• Fourier Transform Infrared Spectroscopy (FTIR) – Carbonyl amide band identification (1650–1680 cm⁻¹)
• ¹H/¹³C NMR Spectroscopy – Ring current and aromatic signature assessment
• Differential Scanning Calorimetry (DSC) – Thermal decomposition behavior

Essential Consumables

• Analytical grade solvents: methanol, ethanol, acetonitrile, chloroform.
• Micropipettes (A class), calibrated balances (0.1 mg sensitivity).
• Amber glass vials with PTFE caps for sample storage.
• Silica‑gel desiccant chambers for humidity control.
• Nitrile gloves, protective eyewear, lab coats, and fume hood ventilation recommended.

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Regulation & Safety

Regulatory Status

• Intended solely for research and analytical use in authorized laboratories.
• May be classified under specific controlled substance schedules depending on jurisdiction (e.g., EU, UN Psychotropic Convention, DEA C‑IV).
• Users must verify regional licensing before procurement and handling.

GHS Hazard Classification (Indicative)

⚠️ Harmful if swallowed (Category 4)
⚠️ Causes mild skin/eye irritation (Category 2)
⚠️ Aquatic chronic toxic (Category 3)

Safety Advice

• Handle only in designated research facilities.
• Prevent ingestion, inhalation, and dermal contact.
• Dispose of unused compound as hazardous organic waste per EPA and REACH guidelines.
• Store in cool (15–25 °C), dry, low‑light conditions within secured chemical inventory.
• Supplied with Safety Data Sheet (SDS) and Certificate of Analysis (CoA).

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Chemical Informatics & Data Integration

• Identifiers:
  • SMILES: Brc1ccc2c(ccc(n2)C(=O)NCCN)
  • InChI and InChIKey included for LIMS indexing
• Metadata: Molecular Weight, TPSA, Log P, Polarizability, H‑bond donor / acceptor counts, rotatable bond count.
• Compatible with ChemAxon, RDKit, KNIME, Open Babel, Schrödinger, and DataWarrior.
• Integrated into QSAR/QSPR and machine learning cheminformatics frameworks.
• Supports FAIR data principles for interoperable scientific datasets.

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Analytical Characterization

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Storage & Stability

• Preserve in airtight amber vial with desiccant.
• Protect from light, heat, and oxidizing agents.
• Stable for 24 months minimum under recommended conditions.

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