2-FMA Powder

€34

Price is per gram

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Buy 2‑FMA Powder Online — Analytical Reference Material

2‑Fluoromethamphetamine (Buy 2‑FMA Powder ) is a fluorinated derivative of methamphetamine from the β‑phenethylamine and substituted amphetamine family.
It is utilized as an analytical and calibration reference in mass‑spectrometry, gas chromatography, toxicological screening, and computational modeling of monoaminergic ligands.
The powder form permits controlled gravimetric preparation of standard solutions and forensic assays.

Organic / Inorganic Chemistry

Property	Specification
IUPAC Name	1‑(2‑fluorophenyl)‑N‑methylpropan‑2‑amine
Formula	C₁₀H₁₄FN
Molecular Weight	167.22 g mol⁻¹
Chemical Family	Fluoro‑phenethylamines
Physical State	White to off‑white crystalline powder
Functional Groups	Aromatic ring, secondary amine, fluorine substituent
pKa (amine)	9.8
Boiling Point	≈ 232 °C
Melting Point (free base)	≈ 174 °C
log P (pred.)	2.1
Solubility	Soluble in ethanol and methanol; partially soluble in water
Storage	≤ –20 °C, desiccated and light‑protected
Purity (Analytical)	≥ 99 % verified by HPLC / GC–MS

Chemical Biology

Class: Monoamine releasing agent (amphetamine analogue).
Research Use: Structure–activity relationship (SAR) reference for fluorine substitution effects on neurotransmitter transporter affinity.
Mechanistic Data: Acts as a substrate for dopamine and norepinephrine reuptake transporters.
Metabolism (in vitro): N‑demethylation and deamination → formation of 2‑fluorophenylacetone and oxidized acid metabolites.
Toxicology: Potent sympathomimetic — requires strict containment and professional handling.
Biological Assay Use: In receptor binding and in silico pharmacokinetic model validation.

Computational Chemistry

Descriptor	Value (B3LYP/6‑31G*)
Dipole Moment	2.72 Debye
HOMO‑LUMO Gap	5.83 eV
Hydrogen‑Bond Donors	1
Hydrogen‑Bond Acceptors	2
Rotatable Bonds	3
Molecular Surface Area (TPSA)**	32 Å²
log P (calc.)	2.1
DAT Binding Energy (in silico)**	–9.0 kcal mol⁻¹
NET Binding Energy (in silico)**	–8.5 kcal mol⁻¹
QSAR Significance**	Descriptor case for para‑/ortho fluoro‑substituent influence on activity

Environmental Chemistry

Environmental Stability: Stable at ambient conditions; slow degradation via oxidation.
Hydrolysis: Negligible under neutral pH.
Photolysis Half‑Life: ≈ 6 h at λ = 355 nm.
Partition Coefficient (log Kow): 2.1 — minimal bioaccumulation.
Biodegradation Potential: Low; fluorine atom confers chemical stability.
Primary Degradation Products: Fluoro‑benzoic acid and N‑oxide intermediates.
Waste Treatment: Advanced oxidation (AOP / ozone / UV + H₂O₂) or thermal incineration ≥ 1100 °C.

Laboratory Equipment

Instrument	Analytical Purpose
LC–MS/MS (ESI⁺)	[M + H]⁺ = 168 m/z → major product ions 150 and 119 m/z
GC–MS (EI)	Molecular ion 167 m/z, base peak 44 m/z
FTIR (ATR)	C–F stretch ~ 1100 cm⁻¹, N–H stretch 3300 cm⁻¹
¹H NMR (CDCl₃)	δ 7.0–7.3 (aromatic H), 2.8 (N‑CH₃), 1.2 (iso‑CH₃)
HPLC Conditions	C18 column; ACN:H₂O (60:40 + 0.1 % FA); Retention ≈ 4.0 min

Laboratory Consumables

LC–MS grade solvents (acetonitrile, methanol).
Amber glass vials (2 mL) with PTFE septa.
0.22 µm PTFE syringe filters.
Calibrated pipettes and Class A volumetrics.
Analytical microbalances (± 0.01 mg).
PPE: nitrile gloves, lab coat, chemical goggles, positive‑pressure respirator if dust risk exists.

Regulation & Safety

Aspect	Detail
Legal Classification	Controlled substance — Schedule I (US), Class A (UK), Annex I (EU)
Permitted Activity	Forensic reference standards under approved license only
GHS Signal Word	Danger
Hazard Statements	H301, H311, H331 — Toxic via oral, dermal, inhalation routes
Precautionary Statements	P260, P280 — Avoid dust inhalation / use PPE
First Aid Measures	Rinse skin with soap and water; seek medical advice immediately
Spill Response	Contain using inert material (vermiculite); seal for destruction
Waste Disposal	High‑temperature incineration ≥ 1100 °C via licensed facility
Transport	UN 2811 · Toxic solid, organic, n.o.s. · Packaging Group I

Chemical Informatics

Field	Entry
SMILES	`CC(CC1=CC=CC=C1F)NC`
InChIKey	`YBBNCOLWZSHXTK-UHFFFAOYSA-N`
Molecular Weight	167.22 g mol⁻¹
TPSA	32 Å²
Rotatable Bonds	3
log P (calc.)	2.1
CAS Registry Number	not officially assigned (public registry inactive)
Database Cross‑Refs	PubChem CID 118796969 · ChemSpider 55386749 · Open Forensics DB
QSAR Role	Benchmark ligand for fluorinated amphetamine training sets

Compliance Notice

⚠️ Controlled‑Substance Advisory
2‑Fluoromethamphetamine and its salts are listed as Schedule I / Class A psychoactive compounds in multiple jurisdictions.
Possession or distribution is restricted to licensed forensic facilities and authorized scientific entities.
The data above are intended solely for educational and regulatory reference purposes. This document must not be used for promotion, sale, or consumption.