Buy 4F-MPH 15mg Pellets Online – (4′‑Fluoromethylphenidate) – Research Reference Material (Pellets 15 mg)
Buy 4F-MPH 15mg pellets is the para‑fluorinated analogue of methylphenidate, included in research programs investigating monoamine reuptake inhibition, SAR optimization, and toxicological detection protocols.
The 15 mg pellet format provides precise mass dosing for instrument calibration, sample validation, and method development under properly licensed laboratory conditions.
Organic / Inorganic Chemistry
| Property | Specification |
|---|---|
| IUPAC Name | Methyl 2‑(4‑fluorophenyl)‑2‑(piperidin‑2‑yl)acetate |
| Formula | C₁₄H₁₈FNO₂ |
| Molecular mass | 251.30 g · mol⁻¹ |
| Functional groups | Ester (C=O–O–CH₃), tertiary amine (piperidine), para‑fluoro‑aryl moiety |
| Chemical class | Halogenated phenidate / piperidine stimulant analogues |
| Physical state | Crystalline powder compressed in pellet form (15 mg) |
| Melting point (HCl salt) | ≈ 190–192 °C |
| Solubility | Moderate in ethanol and methanol; low in water. |
| Reactivity | Stable under dry conditions; hydrolyses under strong alkaline pH. |
Chemical Biology
- Mechanistic focus: Selective dopamine transporter (DAT) and norepinephrine transporter (NET) inhibition.
- In vitro data: Higher affinity to DAT (~35 nM) than methylphenidate (~100 nM).
- Relevance: Serves as a probe for structure‑activity studies on C4‑substituted methylphenidate derivatives.
- Metabolic pathways: Ester hydrolysis → 4‑fluoro‑ritalinic acid + methanol; further oxidative dealkylation via CYP450 enzymes.
- Observed effects in model systems: Increased dopamine uptake blockade; potential neurotoxic risk at high concentrations.
- Research use: Toxicological calibration and neurochemical transport studies only.
Computational Chemistry
| Parameter | Calculated (B3LYP/6‑31G*) |
|---|---|
| Dipole moment | ≈ 2.8 Debye |
| HOMO–LUMO Gap | 5.25 eV |
| log P (pred.) | 2.05 – 2.3 |
| pKa (piperidine N) | 8.6 |
| Topological polar surface area | 38 Ų |
| Docking binding energy (hDAT) | ≈ –9.0 kcal · mol⁻¹ |
| Interpretation: Fluoro‑substitution strengthens π–π interactions and DAT binding affinity. |
Environmental Chemistry
- Stability: Resistant to ambient oxidation; slow degradation under ultraviolet radiation.
- Hydrolysis: Gradual in alkaline solution; forms fluoro‑benzoate and piperidine products.
- Mobility: Low aqueous solubility, moderate sorption on organic soils.
- Persistence: Moderate (weeks to months) in ambient water.
- Bioaccumulation potential: log Kow ≈ 2.1 (moderate).
- Disposal guidance: Collect as hazardous organic waste; destroy via authorized high‑temperature incineration (> 1100 °C).
Laboratory Equipment
| Equipment | Purpose |
|---|---|
| LC‑MS/MS | Quantification at [M+H]⁺ = 252.134; qualitative fragments 84 & 234. |
| GC‑MS (EI) | M⁺ = 251; base ion 84 m/z (piperidine). |
| FTIR | Major bands: 1730 cm⁻¹ (C=O), 1240 cm⁻¹ C–O, 1110 cm⁻¹ C–F. |
| NMR (¹H 500 MHz) | δ 7.2 (ArH), 4.1 (CH–COOCH₃), 2.3 (piperidine CH₂), 3.6 (OCH₃). |
| Weighing apparatus | Microbalance ± 0.1 mg accuracy for pellet calibration. |
| Storage | Desiccated, light‑protected, ≤ –20 °C in controlled substance safe. |
Consumables
- LC‑MS grade methanol and acetonitrile.
- Formic acid (> 99 %), ammonium formate buffers.
- 0.22 µm PTFE filters, amber autosampler vials.
- Certified analytical balances, volumetric flasks, pipette tips.
- PPE requirements: nitrile gloves, lab coat, chemical safety goggles, fume hood.
Regulation & Safety
| Classification | Details |
|---|---|
| Legal status | United States – Schedule I analogue (controlled under Federal Analogue Act); UK – Class B (2016 Psychoactive Substances Regulations); EU – restricted. |
| Permitted applications | Analytical and forensic use under licence only. |
| GHS hazards | H301 (Toxic if swallowed) ∙ H331 (Toxic if inhaled) ∙ H370 (Causes organ damage). |
| Pictograms | ☠️ ⚠️ 🌡️ |
| Precautions | Avoid inhalation; use fume hood; wear double gloves; no public handling. |
| Spill management | Absorb with activated carbon or vermiculite; dispose as hazardous waste. |
| Waste disposal | Certified hazardous waste contractor – incineration >1000 °C. |
Chemical Informatics
| Identifier | Value |
|---|---|
| SMILES | COC(=O)C(C1CCCCN1)C2=CC=C(F)C=C2 |
| InChIKey | VIGXNXDNAOHARM‑UHFFFAOYSA‑N |
| CAS Number | 1354631‑73‑0 |
| Mol Wt. | 251.30 g · mol⁻¹ |
| log P | ≈ 2.1 |
| TPSA | 38 Ų |
| Rotatable bonds | 4 |
| Primary use: Analytical reference and spectral library entry for controlled stimulant screening. |
Ethical & Legal Notice
⚠️ Controlled‑Substance Disclaimer
4F‑MPH (4‑fluoromethylphenidate) is a regulated psychostimulant and may be treated as a Schedule I/Class B substance depending on jurisdiction.
Possession, production, or distribution outside licensed laboratory authorization is illegal.
The information here is for chemical education, forensic research, and regulatory documentation only.
No medical, consumption, or commercial claims are made or implied.
Be the first to review “4F-MPH 15mg Pellets”
Related products
Research Chemicals
Research Chemicals
Research Chemicals
Research Chemicals
Research Chemicals
Research Chemicals
Research Chemicals
Research Chemicals
Reviews
There are no reviews yet.