4-FMA Powder

€57

Price is per gram

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Buy 4‑FMA Powder Online – (4‑Fluoromethamphetamine) — Analytical‑Grade Powder Reference Standard

Buy 4‑FMA powder is an N‑methyl‑substituted amphetamine featuring a para‑fluoro phenyl substitution.
It attracts research interest for its aromatic‑halogen structure–activity variations and neurochemical transporter interactions, compared with methamphetamine and 4‑fluoroamphetamine.

Organic and Inorganic Chemistry

Property	Details
IUPAC Name	1‑(4‑fluorophenyl)‑N‑methylpropan‑2‑amine
Molecular Formula	C₁₀H₁₄FN
Molecular Weight	167.22 g · mol⁻¹
Functional Groups	Primary amine (free base), aryl fluoride, secondary carbon center
Physical Form	Crystalline powder (HCl salt): white to off‑white
Melting Point (HCl)	166 – 169 °C
Boiling Point (free base)	≈ 210 °C (decomposes)
Solubility	Freely soluble in alcohols and chloroform; partially aqueous soluble
Stability	Oxidation‑sensitive; requires dry, light‑protected storage; amine prone to degradation under UV.

Chemical Biology

Pharmacological class: Amphetamine analogue; ring‑fluorinated stimulant.
Mechanistic hypothesis: Acts as a substrate‑type monoamine releaser (DAT, NET, SERT).
SAR note: Fluorination increases lipophilicity and reduces dopaminergic potency relative to methamphetamine, enhancing serotonergic bias.
In vitro use: Binding assays, receptor docking models, reference calibration standards.
Metabolic profile: Oxidative deamination → 4‑fluorophenyl‑2‑propanone and acidic metabolites.
Toxicological signals: Increased ROS and MAO‑dependent stress in dopaminergic cells in vitro.

Computational Chemistry

Descriptor	Value (DFT B3LYP/6‑31G*)
Dipole Moment	2.43 D
HOMO–LUMO Gap	≈ 6.0 eV
Predicted log P	2.4 ± 0.1
pKa (amine)	9.9
Topological Polar Surface Area (TPSA)	26 Å²
Docking energy @ DAT	≈ –9.0 kcal · mol⁻¹
Interpretation: Electron‑withdrawing fluorine reduces ring electron density, influencing π–π and cation–π interactions in transporter binding cavities.

Environmental Chemistry

Photochemical fate: Generates fluorinated benzyl and ketone intermediates under UV; Forms persistent aromatic residues.
Hydrolysis: Stable in neutral pH; hydrolyzes slowly under acidic or basic conditions.
Biodegradability: Moderate (aerobic half‑life ≈ 1 week); fluoroaromatic core is resistant to rapid breakdown.
Volatility: Low vapor pressure (≈ 1 × 10⁻⁴ Pa @ 25 °C).
Waste Management: Collect as hazardous amine; incinerate ≥ 1100 °C via licensed channel.

Laboratory Equipment

Instrument	Analytical Use / Observation
GC–MS (EI)	M⁺ = 167 m/z; diagnostic ions at 135, 119, 91 m/z.
LC–MS/MS	[M+H]⁺ = 168 m/z; fragments 119 (4‑fluorobenzyl ion), 91 (tropylium).
FTIR (ATR)	C–F stretch ≈ 1130 cm⁻¹, amine N–H band ≈ 3350 cm⁻¹, aromatic C=C ≈ 1600 cm⁻¹.
¹H NMR (400 MHz, DMSO‑d₆)	δ 7.10–7.30 (aromatic H), 2.95 (CH₂N), 1.06 (–CH‑CH₃).
Chromatography column type	C18 reverse‑phase (2.6 µm) for qualitative profiling.

Consumables

HPLC‑grade methanol and water.
Ammonium‑formate buffer (5 mM, pH 3.5) for LC–MS analysis.
Amber autosampler vials, PTFE syringe filters (0.22 µm).
Certified weighing boats and safety spatulas.
PPE: lab coat, nitrile gloves, P2 respirator, safety goggles.

Regulation & Safety

Classification	Information
Controlled Status	Schedule I / Class A amphetamine analogue in most nations.
Permitted Usage	Analytical or forensic calibration within licensed laboratories only.
GHS Signal Word	Danger
Hazard Statements	H301 (Toxic if swallowed), H311 (Toxic in contact with skin), H370 (Causes organ damage).
Precautionary Notes	Avoid dust/vapor inhalation, handle within fume hood.
Storage Conditions	≤ –20 °C in vacuum‑sealed, light‑shielded vial in locked facility.
Disposal	Confirmed destruction by licensed hazardous waste contractor.

Chemical Informatics

Field	Data
SMILES	`CC(CC1=CC=C(F)C=C1)NC`
InChIKey	`BMOUKADCBOSAKQ‑UHFFFAOYSA‑N`
Molecular Mass	167.22 g · mol⁻¹
TPSA	26 Å²
Rotatable Bonds	3
log P (predicted)	2.4
CAS Number	351‑03‑7 (reference code for fluoro substituted analogues; verify per salt form)
Use in databases	QSAR/QSPR modelling, forensic profiling, MS library identification.

Legal & Ethical Notice

⚠️ Controlled‑Substance Statement
4‑Fluoromethamphetamine is a regulated psychostimulant analogue whose manufacture, supply, or possession is illegal without appropriate licenses.
This entry serves strictly for academic and forensic reference or informatics integration within authorized institutions.
It must not be interpreted as sales or promotion material.