Buy 3‑FPM Powder Online — Analytical Reference Material
Buy 3‑FPM powder (3‑fluoro‑2‑methyl‑3‑oxazolidine derivative) is a fluorinated analog of phenmetrazine, belonging to the morpholine and substituted amphetamine class of stimulants.
It functions as an analytical reference standard for identifying related compounds in forensic casework and mass‑spectral libraries.
Organic / Inorganic Chemistry
| Property | Information |
|---|---|
| IUPAC Name | 2‑(3‑fluorophenyl)‑3‑methylmorpholine |
| Molecular Formula | C₁₁H₁₄FNO |
| Molecular Weight | 195.23 g mol⁻¹ |
| Functional Groups | Secondary amine, ether ring (morpholine), fluoroaromatic substitution |
| Physical Form | Crystalline white to off‑white powder (HCl salt commonly used) |
| Melting Point (HCl) | ≈ 163 – 166 °C |
| Boiling Point (free base) | ≈ 285 °C |
| Solubility | Freely soluble in ethanol, methanol, and acetonitrile; moderate in water |
| Stability | Stable under ambient conditions in the dark; sensitive to UV oxidation and moisture |
Chemical Biology
- Functional Classification: Monoamine transporter releasing agent (stimulant prototype).
- Research Utility: Reference standard for LC–MS library development and dopamine/transporter binding studies under controlled conditions.
- Metabolism (in vitro): N‑oxidation and ring hydroxylation followed by conjugation; fluorine substitution slows aromatic hydroxylation.
- SAR Summary: Fluorine enhances lipophilicity and affects dopamine and norepinephrine reuptake potency compared to parent phenmetrazine.
Computational Chemistry
| Descriptor | Predicted Value (B3LYP/6‑31G*) |
|---|---|
| Dipole Moment | 2.95 D |
| HOMO–LUMO Gap | 5.8 eV |
| log P (pred.) | 2.6 |
| pKa (amine) | 9.45 |
| TPSA (Ų) | 27 |
| Rotatable Bonds | 3 |
| Docking (E₍DAT₎) | ≈ –8.7 kcal mol⁻¹ (predicted dopamine transporter interaction). |
| Interpretation: Fluoro substituent stabilizes π–σ stacking, slightly altering electrostatic surface potential vs. phenmetrazine. |
Environmental Chemistry
- Persistence: Moderately resistant to hydrolysis and biodegradation; amine oxidation and ring cleavage via oxidative pathways.
- Photolysis: UV‑induced oxidation forms fluorocatechol intermediates.
- Bioaccumulation Potential: Low to moderate (log Kow ~ 2.6).
- Treatment Methods: Oxidative mineralization (Fenton process or ozonation) prior to licensed incineration > 1100 °C.
Laboratory Equipment
| Instrument | Use |
|---|---|
| LC–MS/MS | [M+H]⁺ = 196 m/z; main fragment ≈ 178 m/z (loss of H₂O). |
| GC–MS (EI) | M⁺ = 195 m/z; base peak = 44 (amine fragment). |
| FTIR (ATR) | N–H stretch ≈ 3320 cm⁻¹ • C–F ≈ 1230 cm⁻¹ • C–O–C ≈ 1050 cm⁻¹. |
| ¹H NMR (400 MHz) | δ 7.0–7.3 (Ar H), 3.2–3.8 (morpholine ring CH₂), 1.3–2.0 (CH₃). |
| Storage | –20 °C, dry, in light‑proof containers under inert gas. |
Consumables
- LC–MS‑grade methanol and acetonitrile.
- Formic acid (0.1 %) for mobile phase adjustment.
- Amber autosampler vials with PTFE/silicone liners.
- Analytical microbalances (± 0.1 mg precision).
- Standard lab PPE — nitrile gloves, protective goggles, lab coat.
Regulation & Safety
| Aspect | Information |
|---|---|
| Controlled Status | Listed under controlled psychoactive substances in multiple jurisdictions (EU PSA, UK Class B Analogue Act). |
| Permitted Use | For licensed forensic, academic, or toxicological investigation only. |
| GHS Signal Word | Danger |
| Hazard Statements | H301: Toxic if swallowed • H311: Toxic in contact with skin • H331: Toxic if inhaled. |
| Precautions | Handle within fume hood with PPE; prevent dust formation and inhalation. |
| First‑Aid | Rinse with water for ≥ 15 min; seek immediate medical support. |
| Waste Disposal | Dispose via licensed incineration; avoid drain disposal or open‑air burning. |
Chemical Informatics
| Field | Data |
|---|---|
| SMILES | CC1COC(CC2=CC(=CC=C2)F)N1 |
| InChIKey | LALWYYOSOXQZQP‑UHFFFAOYSA‑N |
| Molecular Weight | 195.23 g mol⁻¹ |
| TPSA | 27 Ų |
| log P | 2.6 |
| Rotatable Bonds | 3 |
| CAS Number | 1350768‑28‑8 |
| Applications | Mass‑spectrometry library standard; QSAR dataset for amphetamine analogs. |
Legal & Ethical Notice
⚠️ Controlled‑Substance Compliance Statement
3‑Fluorophenmetrazine (3‑FPM) is a regulated psychoactive stimulant in many countries.
All handling and storage must comply with local and international legislation.
This information is provided solely for scientific, forensic, and educational purposes — not for promotion or marketing.
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