GW-0742 Powder

Buy GW-0742 Powder Online

Buy GW-0742 Powder is a potent and highly selective agonist of peroxisome proliferator-activated receptor delta (PPARδ), utilized in scientific research to investigate lipid metabolism, cardiovascular health, and neuroprotection. Available in powder form, GW-0742 is intended strictly for laboratory and analytical purposes.

Chemical Composition and Properties

• Chemical Name: 2-[4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]-acetic acid
• Molecular Formula: C₂₁H₁₇F₄NO₃S₂
• Molecular Weight: 471.49 g/mol
• CAS Number: 317318-84-6
• Appearance: White to off-white crystalline powder
• Solubility: Soluble in DMSO (≥47.1 mg/mL) and ethanol (≥49.7 mg/mL with ultrasonic and warming); insoluble in water
• Storage Conditions: Store at -20°C in a dry environment

These properties are crucial for researchers to consider when designing experiments and handling the compound.

Mechanism of Action

GW-0742 functions as a selective PPARδ agonist with an EC₅₀ value of 1.1 nM, exhibiting 1,000-fold selectivity over other human PPAR subtypes. Activation of PPARδ by GW-0742 influences gene expression involved in lipid metabolism, energy homeostasis, and inflammation. Studies have demonstrated its neuroprotective effects in rat cerebellar granule neuronal cultures; however, prolonged exposure (48 hours) has been associated with inherent toxicity.

Laboratory Equipment and Consumables

When conducting research with GW-0742 powder, it’s essential to utilize appropriate laboratory equipment and consumables to ensure accurate and safe experimentation. This includes:

• Precision Balances: For accurate weighing of the compound.
• Solvent-Resistant Containers: For dissolution and storage of solutions.
• Personal Protective Equipment (PPE): Gloves, safety goggles, and lab coats to prevent exposure.
• Storage Solutions: Desiccators and temperature-controlled environments to maintain compound stability.

Regulation and Safety

GW-0742 is intended for research use only and is not approved for human or veterinary use. Researchers should adhere to the following safety protocols:

• Handling: Use protective equipment when handling the powder to prevent inhalation or skin contact.
• Ventilation: Ensure proper laboratory ventilation to minimize exposure to dust or vapors.
• Storage: Store the compound at -20°C in a dry environment to maintain stability.
• Disposal: Dispose of GW-0742 and related materials in accordance with local regulations regarding hazardous waste.

Refer to the Material Safety Data Sheet (MSDS) for detailed information on hazards and safety measures.

Chemical Informatics

Utilizing chemical informatics tools can aid researchers in understanding GW-0742’s properties, interactions, and potential applications. Databases such as PubChem provide comprehensive information on chemical structures, biological activities, safety, and toxicity data. These resources are invaluable for designing experiments and predicting outcomes.

Conclusion

GW-0742 powder serves as a valuable tool in the study of PPARδ-related pathways and their implications in various physiological processes. Due to its potent biological activity and regulatory status, it is imperative that researchers handle this compound with caution, adhere to safety protocols, and stay informed about legal considerations.