Buy 5‑Bromo‑DMT Powder Online – (5‑Bromo‑N,N‑Dimethyltryptamine) — Analytical Reference Profile
Buy 5‑Bromo‑DMT powder is a halogenated tryptamine derivative, belonging to the indole alkaloid family.
It occurs naturally in certain marine sponges (Smenospongia aurea, Smenospongia echina) and is also synthesized for neurochemical and receptor‑binding studies.
In research form, it is handled as a powdered freebase or hydrobromide salt, typically < 100 mg aliquots under controlled‑substance licence.
Organic / Inorganic Chemistry
| Property | Details |
|---|---|
| IUPAC Name | 2‑(5‑Bromo‑1H‑indol‑3‑yl)‑N,N‑dimethylethanamine |
| Formula | C₁₂H₁₅BrN₂ |
| Molecular mass | 267.17 g · mol⁻¹ |
| Type | Substituted indole (tryptamine) |
| Functional groups | Tertiary amine, indole NH, aryl bromide |
| Appearance | Beige–tan crystalline powder |
| Boiling point | ≈ 325 °C (decomp.) |
| Solubility | Low in water; soluble in methanol, ethanol, chloroform |
| Reactivity | Sensitive to UV light and oxidation; halogen reactive in Grignard conditions |
Chemical Biology
- Pharmacological class: Tryptamine derivative with 5‑HT receptor activity.
- Mechanism (analytical level): Partial agonist at 5‑HT₂A and 5‑HT₁A in vitro.
- Physiological origin: Found in marine sponges — hypothesized chemical defense metabolite.
- Neurochemistry: Halogen substitution alters lipophilicity and receptor bias compared to DMT.
- Metabolism (model): Deamination via MAO‑A, O‑demethylation, and bromine retention in major metabolites.
- Laboratory application: Used for receptor‑binding assays and pharmacophore modelling studies.
- ⚠️ Potential psychoactive properties – human use prohibited.
Computational Chemistry
| Descriptor | Value (B3LYP/6‑31G*) |
|---|---|
| Dipole moment | 3.1 D |
| HOMO–LUMO gap | ≈ 4.8 eV |
| Pred. log P | 3.1–3.3 |
| TPSA | 41 Ų |
| Rotatable bonds | 4 |
| pKa (amine) | 8.9 |
| Docking energy at 5‑HT₂A | ~ –8.9 kcal mol⁻¹ |
| Comment: Bromo‑substitution enhances binding affinity via halogen π interactions. |
Environmental Chemistry
- Natural occurrence: Produced by marine sponges as secondary metabolite.
- Degradation: Photolabile; decomposes to indole‑2‑carboxaldehyde and bromide ions.
- Persistence: Low under UV and oxidative seawater conditions.
- Bioaccumulation: Moderate due to lipophilic character (log Kow ≈ 3.1).
- Environmental handling: Collect waste in halogenated organic containers for licensed destruction.
Laboratory Equipment
| Equipment | Purpose |
|---|---|
| LC‑MS/MS | [M+H]⁺ = 267.045; characteristic ions [250], [72]. |
| GC‑MS (EI) | M⁺ = 267; fragments 58, 130, 156. |
| FTIR | 3400 cm⁻¹ (indole NH), 1690 cm⁻¹ aromatic C═C, 500 cm⁻¹ C–Br stretch. |
| ¹H NMR (500 MHz) | δ 7.1–7.5 ppm aromatic, 3.1 ppm N‑CH₃, 2.8 ppm CH₂CH₂N. |
| Storage | Deep freeze (–20 °C), light‑protected, nitrogen‑purged bottle in locked vault. |
Consumables
- LC‑MS‑grade methanol and water.
- Formic acid (0.1 %), ammonium formate mobile phase.
- Amber autosampler vials, PTFE caps.
- Nitrile gloves, lab coat, safety glasses, fume hood.
- Class A volumetric glassware and calibrated micropipettes.
Regulation & Safety
| Category | Specification |
|---|---|
| Legal status | Schedule I (USA), Class A (UK Psychoactive Substances Act 2016) |
| Permitted use | Analytical and forensic research under controlled licence. |
| GHS classification | Acute Toxic Cat 3 – H301/H331; STOT SE Cat 1 – H370. |
| Pictograms | ☠️ ⚠️ 🌡️ |
| Storage class | Controlled substance safe – restricted key access. |
| PPE | Lab coat, nitrile gloves, eye protection, fume hood use only. |
| Disposal | Licensed incineration at ≥ 1100 °C; no solvent drains or general waste disposal. |
Chemical Informatics
| Identifier | Value |
|---|---|
| SMILES | CN(C)CCC1=CNC2=C1C=C(C=C2)Br |
| InChIKey | KULUJBRLFCGQKZ‑UHFFFAOYSA‑N |
| CAS Registry | 434‑90‑2 |
| Molecular weight | 267.17 g mol⁻¹ |
| log P | 3.12 (estimated) |
| TPSA | 41.1 Ų |
| Rotatable bonds | 4 |
| Applications | Spectral database entries, halogen SAR computations, marine metabolite comparisons. |
Ethical & Legal Notice
⚠️ Controlled‑Substance Disclaimer
5‑Bromo‑DMT and its derivatives are regulated under Schedule I and Class A drug laws in multiple jurisdictions.
Possession, manufacture, or distribution without authorisation is a criminal offence.
The information presented here is for scientific, environmental, and safety documentation only.
No claims are made about human or veterinary use.
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