Buy 4F-MPH 30mg Pellets Online - (4′‑Fluoro‑Methylphenidate) — Analytical Reference (30 mg Pellet Equivalent)
Buy 4F-MPH 30mg pellets is a fluorinated analog of methylphenidate (Ritalin®) belonging to the piperidine‑based phenethylamine family.
It is used under schedule‑licensed research settings to investigate dopaminergic and noradrenergic reuptake inhibition, QSAR relationships, and forensic toxicology calibration.
The “30 mg pellet” format designates a precisely weighed laboratory unit — not a pharmaceutical dosage.
Organic / Inorganic Chemistry
| Property | Details |
|---|---|
| IUPAC Name | Methyl 2‑(4‑fluorophenyl)‑2‑(piperidin‑2‑yl)acetate |
| Formula | C₁₄H₁₈FNO₂ |
| Molar mass | 251.30 g · mol⁻¹ |
| Molecular type | Halogenated methylphenidate analogue |
| Functional groups | Ester (C=O–O–CH₃), tertiary amine (piperidine), fluoro‑aryl substitution |
| Physical form | White/off‑white crystalline powder compressed into pellet for mass precision |
| Boiling point (est.) | ≈ 340 °C (decomp.) |
| Solubility | Moderate in methanol and ethanol; low in water; soluble in dilute HCl. |
Chemical Biology
- Mechanistic activity: Potent dopamine and norepinephrine reuptake inhibitor (DAT/NET); minimal activity at serotonin transporter.
- Binding affinity ratios: DAT ≫ SERT; Ki (DAT) ≈ 35 nM vs methylphenidate ≈ 100 nM.
- In vitro application: Used to model halogen substitution effects on psychostimulant potency.
- Metabolism: Ester hydrolysis → 4‑fluoro‑ritalinic acid + methanol; oxidative dealkylation pathways.
- Toxicology: Observed hyperthermia, tachycardia, and stimulant‑like neurotoxicity in animal models.
- Research Use: Behavioural pharmacology and molecular docking studies only.
Computational Chemistry
| Descriptor | Calculated (B3LYP/6‑31G*) |
|---|---|
| Dipole moment | 2.8 D |
| HOMO–LUMO gap | ≈ 5.3 eV |
| Pred. log P | 2.0 – 2.3 |
| TPSA | 38 Ų |
| Rotatable bonds | 4 |
| pKa (piperidine N) | 8.6 |
| Docking energy @ hDAT | –9.1 kcal mol⁻¹ |
| Observation: Fluoro‑substitution enhances π‑stacking and DAT affinity vs. parent methylphenidate. |
Environmental Chemistry
- Chemical stability: Stable in neutral aqueous solution; slow hydrolysis in alkaline media.
- Photolysis: Degrades to 4‑fluorophenol and piperidine‑based esters.
- Biodegradation: Low; persists in sediments and organic‑rich soils.
- Bioaccumulation: Moderate (log Kow ≈ 2.1).
- Containment: Collect organic waste for destruction — do not drain.
- Disposal: High‑temperature (> 1100 °C) licensed incineration or chemical oxidation (NaOCl/H₂O₂).
Laboratory Equipment
| Instrument | Analytical Purpose |
|---|---|
| LC‑MS/MS | [M+H]⁺ = 252.134; fragments 84, 234, 175 m/z. |
| GC‑MS (EI) | M⁺ = 251; base peak = 84 (piperidinium fragment). |
| FTIR | 1730 cm⁻¹ (C=O), 1230 cm⁻¹ C–O, 1090 cm⁻¹ C–F. |
| ¹H NMR (500 MHz) | δ 7.2 (Ar 4H), 4.1 (CH–COOCH₃), 2.3 piperidine CH₂, 3.6 (OCH₃). |
| Pellet standardization | Mass uniformity testing ± 2 %; HPLC content verification. |
| Storage | ≤ –20 °C, amber sealed, controlled‑substance safe. |
Consumables
- HPLC/LC‑MS grade methanol, acetonitrile, and formic acid.
- Analytical reagent water, 0.22 µm filters, amber sample vials.
- Nitrile gloves, lab coat, chemical safety goggles.
- Disposable spatulas and weighing boats for controlled substance handling.
- Certified microbalance and Class A glassware for precision weighing.
Regulation & Safety
| Aspect | Specification |
|---|---|
| Legal status | Schedule I (USA analogue to methylphenidate), Class B (UK PSA 2016). |
| Permitted use | Analytical reference and toxicology only under controlled licence. |
| GHS Hazards | H301 Toxic if swallowed; H331 Toxic if inhaled; H370 Causes organ damage. |
| Pictograms | ☠️ ⚠️ 🌡️ |
| Storage class | Controlled narcotic safe, double locked; temperature‑monitored. |
| PPE | Nitrile gloves, respirator mask for powders, safety eye protection. |
| Spill response | Adsorb onto activated carbon; dispose in hazardous waste container. |
| Disposal | Via licensed contractor — thermal destruction. |
Chemical Informatics
| Identifier | Value |
|---|---|
| SMILES | COC(=O)C(C1CCCCN1)C2=CC=C(F)C=C2 |
| InChIKey | VIGXNXDNAOHARM‑UHFFFAOYSA‑N |
| CAS Number | 1354631‑73‑0 |
| Molecular Weight | 251.30 g mol⁻¹ |
| log P | ≈ 2.1 |
| TPSA | 38 Ų |
| Rotatable bonds | 4 |
| Data applications | QSAR modelling, mass‑spectral databases, regulatory screening systems. |
Ethical & Legal Notice
⚠️ Controlled‑Substance Disclaimer
4F‑MPH is a restricted psychostimulant substance under the U.S. Federal Analogue Act and EU Psychoactive Substance Regulations.
Manufacture, sale, or use outside licensed research is illegal and punishable under national law.
The above data serve only scientific, educational, and toxicological documentation purposes.
Be the first to review “4F-MPH 30mg Pellets”
Related products
Research Chemicals
Research Chemicals
Research Chemicals
Research Chemicals
Research Chemicals
Research Chemicals
Research Chemicals
Research Chemicals
Reviews
There are no reviews yet.