4-HO-MET 20mg Pellets

€6

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Buy 4‑HO‑MET 20mg Pellets Online – (4‑Hydroxy‑N‑methyl‑N‑ethyltryptamine)  — Analytical Reference Standard

Buy 4‑HO‑MET 20mg pellets is a structural analogue of psilocin (4‑HO‑DMT) and belongs to the indole‑based tryptamine family.
It is typically prepared as a fumarate or hydrochloride salt and used in forensic toxicology or receptor‑binding simulation studies.
Researchers investigate how side‑chain substitutions (ethyl vs dimethyl) affect serotonin receptor interactions and metabolism.

Organic / Inorganic Chemistry – Buy 4‑HO‑MET 20mg Pellets

Property	Details
IUPAC Name	3‑(2‑(ethyl(methyl)amino)ethyl)‑1H‑indol‑4‑ol
Molecular Formula	C₁₃H₁₈N₂O
Molecular Weight	218.30 g · mol⁻¹
Functional Groups	Secondary amine, indolic aromatic ring, phenolic hydroxyl, ethyl alkyl substituent
Physical Form	Off‑white to beige crystalline solid (salt form)
Melting Point (fumarate)	≈ 148–150 °C
Solubility	Freely soluble in methanol, ethanol, chloroform; limited in water
Stability	Sensitive to oxidation and UV light; store cold and inert atmosphere (< –20 °C).

Chemical Biology

Pharmacological class: Tryptamine serotonergic agonist.
Mechanism of action: Partial agonism at 5‑HT₂A/2C and 5‑HT₁A receptors; minimal dopaminergic activity.
SAR Observation: Ethyl substitution on the amine increases hydrophobic interaction energy (~0.3 kcal mol⁻¹ more than psilocin).
Metabolism: Likely phase I oxidative deamination and glucuronidation of the 4‑hydroxy group.
Laboratory use: Spectral reference for MS libraries and QSAR studies of indole derivatives.
Toxicological note: Low acute in‑vitro cytotoxicity but considered Class A psychedelic risk compound.

Computational Chemistry

Parameter	B3LYP/6‑31G* Estimate
Dipole Moment	3.1 Debye
HOMO–LUMO Gap	≈ 5.7 eV
Predicted log P	1.7–1.9
pKa	9.9 (amino group) / 10.1 (phenolic OH)
TPSA	54 Å²
Rotatable Bonds	5
Docking Energy (5‑HT₂A)	≈ –9.6 kcal · mol⁻¹
Interpretation: The 4‑hydroxyl bonding and ethyl‑methyl amine moiety adjust π‑stacking geometry within the indole pocket differently than psilocin.

Environmental Chemistry

Hydrolysis: Stable under neutral pH; degrades in strong acidic media.
Photodegradation: Produces indole‑quinone derivatives upon UV exposure.
Biodegradability: Moderate; natural microbial enzymes can oxidize indole groups over weeks.
Waste Code: Hazardous organic amine category.
Waste Treatment: Controlled incineration (≥ 1100 °C) under licensed protocols.
Environmental Impact: Trace aromatic amines are aqueous toxins at < µg/L levels; avoid drain discharge.

Laboratory Equipment

Instrument	Use
LC‑MS/MS	[M+H]⁺ = 219.149 m/z; dominant fragment 160 m/z (indole break).
GC–MS (EI)	M⁺ = 218 m/z; chromatographic derivatization often required.
FTIR	Broad 3400 cm⁻¹ (–OH), 1620 cm⁻¹ (indole C=C), 1220 cm⁻¹ (C–N).
UV‑Vis	λₘₐₓ ≈ 278 nm (indole π→π* transition).
NMR (¹H, 400 MHz)	δ 7.0–7.3 (aromatic H), 2.8–3.5 (CH₂N), 1.0–1.2 (ethyl CH₃).
Storage	Light‑protected glass vials, nitrogen flushed, ≤ –20 °C.

Consumables

- HPLC‑grade methanol & water
- Ammonium‑formate buffer (5 mM, pH 3.5)
- Amber autosampler vials to reduce UV oxidation
- PTFE syringe filters (0.22 µm)
- Analytical weighing boats and pipette tips
- PPE: nitrile gloves, spectacles, lab coat, fume‑hood operations mandatory

Regulation & Safety

Classification	Information
Controlled Status	Often listed with psilocin and its analogues (Class A / Schedule I substance).
Permitted Use	Analytical reference and forensic toxicology under controlled‑drug licenses.
GHS Hazards	H301 (Toxic if swallowed) • H317 (May cause allergic skin reaction) • H370 (Causes organ damage).
Pictograms	☠️ ⚠️ 🌡️
Precautions	Do not inhale dust or vapor; avoid oxidation sources; use grounded equipment.
First Aid	Rinse affected areas with water ≥ 15 min; seek medical attention.
Storage	Locked safe under cool dry conditions; inventory log per local authority rules.
Disposal	Transfer to licensed hazardous waste incinerator only.

Chemical Informatics

Identifier	Data
SMILES	`CCN(C)CCc1c[nH]c2cccc(O)c12`
InChIKey	`ZCFFVIDGUGUKLB‑UHFFFAOYSA‑N`
Molecular Weight	218.30 g · mol⁻¹
TPSA	54 Å²
Rotatable Bonds	5
Predicted log P	1.8
CAS Number	122760‑83‑8
Database Application	Molecular descriptor generation, psychedelic SAR modelling, and MS spectral reference entries.

Legal & Ethical Statement

⚠️ Controlled Substance Notice
4‑HO‑MET is analogous to psilocin and is regulated under Schedule I / Class A acts in most jurisdictions.
This document serves only for chemical informatics, toxicology, and forensic education within licensed research entities.
Its production, distribution, or use outside authorized laboratories is illegal and punishable under drug‑control laws.