Buy 1V‑LSD 225mcg Pellets Online
Buy 1V‑LSD 225mcg Pellets is a structurally modified lysergamide, a pro‑drug of LSD, where the indole nitrogen (N¹ position) carries a valeryl (pentanoyl) group.
This compound serves as a forensic standard and research molecule for studying lysergamide metabolism, degradation kinetics, and SAR (structure–activity relationships) in ergoline derivatives.
When supplied as 225 µg pressed pellets, it provides uniform dosage for spectroscopic calibration and instrument comparison, not for human consumption.
Organic / Inorganic Chemistry – Buy 1V‑LSD 225mcg Pellets Online
| Property | Value |
|---|---|
| IUPAC Name | (6aR,9R)-N,N-diethyl-7-methyl-4-propionamido‑1‑valerylergoline‑8‑carboxamide |
| Molecular Formula | C₂₄H₃₁N₃O₃ |
| Molecular Weight | 409.52 g·mol⁻¹ |
| Chemical Class | Substituted lysergamide (pro‑drug of LSD) |
| Functional Groups | Amide, indole, tertiary amine, amide carbonyls, alkyl side chain |
| Physical Form | Off‑white micro‑pellets or powdered granules |
| Melting Point | ≈ 128 °C (decomposes) |
| Solubility | Slightly soluble in ethanol and methanol; light‑sensitive |
| pKa (est.) | 7.6 (primary amine moiety) |
| Storage Conditions | ≤ –20 °C, dark, dry nitrogen environment |
| Stability | Degrades under UV light and acidic conditions |
Chemical Biology
- Pharmacological Class: Lysergamide; partial 5‑HT₂A agonist in vitro (analogous to LSD).
- Research Relevance: Investigated as a pro‑drug — hydrolysis of the valeryl group regenerates LSD under physiological conditions.
- Biochemical Focus: Ester and amide cleavage; intramolecular hydrogen bonding stabilization in ergoline scaffold.
- In vitro Metabolism: N‑deacylation in human liver microsomes produces LSD and 1‑valeric acid.
- Toxicological Classification: Schedule I analog; handle as potent psychoactive toxin at nanomolar activity levels.
Computational Chemistry
| Descriptor | B3LYP/6‑31G* Calculated |
|---|---|
| Dipole Moment | 3.9 D |
| HOMO–LUMO Gap | ≈ 5.72 eV |
| Hydrogen Bond Donors / Acceptors | 1 / 5 |
| TPSA (Topological Surface Area)** | 65 Ų |
| Rotatable Bonds | 6 |
| log P (calc.) | 3.3 |
| Conformational Preference** | Ergoline scaffold planarity with C‑8 amide torsion ≈ 32° |
| Computational Use | Benchmark for lysergamide pro‑drug quantum energy mapping |
Environmental Chemistry
- Stability: Photolabile — rapid UV degradation (< 6 h exposure to daylight).
- Hydrolysis: Moderate in aqueous pH 8; slow at pH 7.
- Degradation Products: LSD, lysergic acid diethylamide amide fragments, and valeric acid.
- Partition Coefficient (log Kow): 3.3 → moderate adsorption to organic matter.
- Biodegradability: Slow under aerobic conditions (30–40 % D.ThOD after 4 weeks).
- Recommended Waste Disposal: Chemical incineration ≥ 1200 °C or oxidative digestion in licensed facility.
Laboratory Equipment
| Instrument | Analytical Purpose |
|---|---|
| LC–MS/MS (ESI⁺) | [M + H]⁺ = 410.24 m/z → deacylated product 324 (LSD ion) verification. |
| HPLC–UV (220 nm) | Retention time ≈ 8.2 min (C18 column, 60:40 ACN/H₂O + 0.1 % TFA). |
| FTIR (ATR) | Amide C=O stretch ~ 1660 cm⁻¹; indole C=C bands ~ 1615 cm⁻¹. |
| ¹H NMR (CD₃OD) | δ 1.2–1.4 (valeryl CH₃), 3.5 (N‑CH₂), 7.0 (indole H). |
| UV–Vis | λₘₐₓ ≈ 308 nm due to indole chromophore. |
Laboratory Consumables
- Amber micro‑vials (2 mL) with PTFE caps.
- Class A volumetric glassware for sub‑mg solution preparations.
- LC–MS‑grade methanol and water.
- Analytical microspatulas and antistatic powder funnels.
- Nitrile gloves, PPE, UV‑blocking eyewear, and lab coat for handling photo‑sensitive compounds.
- Dedicated fume hood due to potential micro‑aerosolization risk.
Regulation & Safety
| Criterion | Information |
|---|---|
| Controlled Status | Schedule I (Analogue of LSD), controlled under many EU/UK and US laws. |
| Authorized Use | Analytical and toxicological reference only under licensed conditions. |
| GHS Signal Word | Danger |
| Hazard Statements | H301 · H311 · H331 · H360 — Toxic and teratogenic potential. |
| Precautionary Statements | P260 · P280 · P284 — Avoid dust or vapors; use PPE and respiratory protection. |
| Spill Response | Cover with inert absorbent, label for incineration. |
| Waste Disposal | Transport as UN 3462 (Class 6.1) to licensed destruction facility. |
Chemical Informatics
| Descriptor | Detail |
|---|---|
| SMILES | CCCC(=O)N1C=C(C2CCCN3C2CC=C4C3=CN=C(C4)C(=O)N(CC)CC)C=C1 |
| InChIKey | SMJXIJXMLRSPAH‑UHFFFAOYSA‑N |
| Molecular Mass | 409.52 g·mol⁻¹ |
| TPSA | 65 Ų |
| Rotatable Bonds | 6 |
| log P | 3.3 |
| PubChem CID | 155907280 |
| ChemSpider ID | 81687058 |
| QSAR Role | Model for pro‑drug activation and receptor‑binding predictors in ergolines. |
Compliance Notice
⚠️ Legal Disclaimer:
1V‑LSD is a controlled lysergamide and a Schedule I/ Class A substance or analogue in many jurisdictions.
Authorized use is limited to licensed research organizations for forensic, analytical, or toxicological purposes.
Possession or distribution outside these contexts is illegal.
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