Buy 1cP-AL-LAD 150mcg Blotters Online
Buy 1cP-AL-LAD 150mcg Blotters is a semi‑synthetic lysergamide featuring a cyclopropionyl (1‑acyl) group at the indole‑N¹ position and an allyl group at C‑6 of the ergoline skeleton.
This substitution pattern increases hydrophobicity relative to LSD and alters the compound’s hydrolysis kinetics.
The 150 µg blotter format is used for calibration of analytical instrumentation, QC validation, and forensic reference of lysergamide analogues.
Organic / Inorganic Chemistry
| Property | Specification |
|---|---|
| IUPAC Name | (6aR,9R)‑N,N‑diethyl‑7‑methyl‑4‑(1‑cyclopropanecarboxamido)‑6‑allylergoline‑8‑carboxamide |
| Formula | C₂₆H₃₃N₃O₂ |
| Molecular Weight | 419.57 g·mol⁻¹ |
| Core Structure | Indole‑lysergamide (ergoline skeleton) |
| Functional Groups | Indole ring, allyl substituent, two amide carbonyls, tertiary amine |
| Physical State | Impregnated cellulose paper (blotter substrate) |
| Appearance | White/printed square, art‑grade cellulose matrix |
| Solubility | Soluble in methanol and ethanol; slightly soluble in chloroform; insoluble in water |
| log P (calc.) | 3.1 |
| pKa (amine) | 7.2 |
| UV λₘₐₓ | ~307 nm |
| Stability | Light‑ and humidity‑sensitive; store ≤ –20 °C in dark, airtight conditions |
Chemical Biology
- Category: Lysergamide ergoline; LSD‑type analogue bearing allyl and cyclopropionyl substitutions.
- Analytical Use: Comparative reference for identifying acylated ergolines via mass spectrometry and chromatography.
- Biochemical Behaviour: Hydrolyzes to AL‑LAD under acidic and enzymatic conditions, serving as a model for LSD prodrug studies.
- Mechanism: Cyclopropanoyl group reduces indole electron density, producing distinct spectral signatures.
- Handling Note: Potent microgram‑active material — always use within Class II biosafety cabinet under licensed conditions.
Computational Chemistry
| Descriptor | Data (B3LYP/6‑31G*) |
|---|---|
| Dipole Moment | 3.5 D |
| HOMO–LUMO Gap | 5.9 eV |
| Predicted log P | 3.1 |
| Rotatable Bonds | 7 |
| TPSA | 63 Ų |
| Hydrogen Bond Donors / Acceptors | 1 / 5 |
| Conformational Angle (amide twist) | ≈ 31° |
| Computational Utility | QSAR model training for ergoline receptor binding predictors and hydrolytic stability estimation. |
Environmental Chemistry
- Photolysis: Quickly decomposes in direct sunlight (half‑life < 6 h).
- Hydrolysis: Reverts to AL‑LAD and cyclopropionic acid in mild acid/base conditions.
- Biodegradation: Partial mineralization (≈ 35 % in aerobic systems over 28 days).
- Partition Coefficient (log Kow): 3.1 → moderate lipophilicity.
- Ecotoxicity: Classified as toxic organic waste (T61); prevent release to sewer systems.
- Waste Disposal: Oxidize with alkaline NaOCl solution, adsorb on activated carbon, incinerate at ≥ 1200 °C in authorized facilities.
Laboratory Equipment
| Instrument | Analytical Purpose |
|---|---|
| HPLC‑DAD (220 nm) | Quantification and purity profile verification (C18 column retention ≈ 8.0 min). |
| LC‑MS/MS (ESI⁺) | [M + H]⁺ = 420.24 m/z; fragment 337.23 m/z (AL‑LAD core). |
| GC–MS (EI) | Distinct M⁺ = 419 m/z with allyl fragment pattern. |
| FTIR (ATR) | C=O amide band 1652 cm⁻¹; C=C stretch 1609 cm⁻¹. |
| UV–Vis | λₘₐₓ ≈ 307 nm for concentration assay. |
| Analytical Balance (0.001 mg) | Microbatch calibration of blotter mass uniformity. |
Laboratory Consumables
- LC/MS‑grade methanol, acetonitrile, water.
- Amber autosampler vials with PTFE/silicone caps.
- 0.22 µm PTFE filters.
- Certified pipette tips and volumetric flasks (1 µL to 2 mL range).
- Disposable nitrile gloves, protective glasses, lab coats.
- Anti‑static forceps for blotter handling.
- Desiccant storage systems for humidity control.
Regulation & Safety
| Parameter | Information |
|---|---|
| Controlled Status | Schedule I / Class A lysergamide analogue (EU, UK, US jurisdictions). |
| Permitted Usage | Accredited research, analytical testing, forensic toxicology. |
| GHS Signal Word | DANGER |
| Hazard Statements | H300, H310, H330, H360 — Fatal if swallowed/inhaled; may damage reproductive organs. |
| Precautionary | P260, P280, P284, P501 — Use PPE; handle only in biosafety cabinet; dispose as hazardous waste. |
| Transport Label | UN 3462 — “Toxic solid, organic n.o.s.” (Class 6.1). |
| Emergency Measures | Controlled‑substance spillage to be contained with absorbent and incinerated. |
| Storage Conditions | ≤ –20 °C, dark, dry, nitrogen‑flushed amber containers. |
Chemical Informatics
| Descriptor | Value |
|---|---|
| SMILES | CCN(CC)C(=O)N1C=C(C2CCCN3C2CC=C4C3=CN=C(C4)C(=O)N1C1CC1)CC=C |
| InChIKey | AYHOGNAJYVLKRB‑UHFFFAOYSA‑N |
| Molecular Weight | 419.57 g·mol⁻¹ |
| Rotatable Bonds | 7 |
| TPSA | 63 Ų |
| Predicted log P | ≈ 3.1 |
| Key LC–MS transition | 420.24 → 337.23 m/z (AL‑LAD core signal). |
| Database Application | Entry for ergoline QSAR/QSPR datasets and forensic identification libraries. |
Compliance Notice
⚠️ Regulatory Advisory
1cP‑AL‑LAD is a Schedule I / Class A controlled substance analogue under most jurisdictions (EU PSA, UK MDA 1971, US CSA).
Possession or use outside licensed laboratories is prohibited.This information is intended solely for scientific, forensic, and academic reference — not for advertisement or promotion of psychoactive materials.
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