MK-677 Powder (Istobal/Nutrobal)

Buy MK-677 Powder (Istobal/Nutrobal) Online 

Chemical Composition and Properties

• Chemical Name: 2-Amino-2-methyl-N-[1-(1-methylsulfonylspiro[2H-indole-3,4′-piperidine]-1′-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide
• Molecular Formula: C₂₈H₄₀N₄O₈S₂
• Molecular Weight: 624.77 g/mol
• CAS Number: 159752-10-0
• Appearance: White to off-white crystalline powder
• Solubility: Soluble in water (≥50 mg/mL), DMSO (50 mg/mL), ethanol (~10 mg/mL), and PBS (pH 7.2) (~10 mg/mL)

Biological Significance

Buy MK-677 Powder, also known as Ibutamoren, is a non-peptidic, potent, and selective agonist of the ghrelin receptor. It stimulates the secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), mimicking the GH-stimulating action of the endogenous hormone ghrelin. This compound has been investigated for its potential to increase lean body mass and improve bone density. However, it is important to note that MK-677 is not approved for human therapeutic use in most jurisdictions and remains an investigational compound.

Regulatory Status and Safety Considerations

In the United States, MK-677 is classified as an unapproved new drug by the Food and Drug Administration (FDA). Its sale for human consumption is illegal, and the FDA has issued warning letters to companies illegally selling products containing MK-677. Additionally, the World Anti-Doping Agency (WADA) includes MK-677 on its Prohibited List, banning its use in competitive sports.

Safety concerns associated with MK-677 include increased appetite, fluid retention, elevated blood glucose levels, and potential cardiovascular effects. A clinical trial was halted early due to concerns that MK-677 may increase the risk of congestive heart failure in certain populations.

Laboratory Handling and Equipment

When handling MK-677 powder in a laboratory setting, it is essential to:

• Personal Protective Equipment (PPE): Wear appropriate PPE, including gloves, safety goggles, and lab coats, to prevent inhalation, ingestion, and skin contact.
• Engineering Controls: Utilize fume hoods and ensure proper ventilation to minimize exposure to dust or vapors.
• Storage: Store the compound at room temperature in a tightly closed container, in a dry and well-ventilated place.

Environmental Impact

There is limited information on the environmental impact of MK-677. As with all chemical compounds, proper disposal procedures should be followed to minimize potential environmental contamination.

Chemical Informatics

For computational chemistry applications, MK-677’s molecular structure and properties can be analyzed using various chemical informatics tools. Its IUPAC name is 2-amino-2-methyl-N-[1-(1-methylsulfonylspiro[2H-indole-3,4′-piperidine]-1′-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide, and it has a molecular weight of 624.77 g/mol.

Conclusion

MK-677 Powder is utilized in research settings to explore its pharmacological properties and potential therapeutic applications. Due to regulatory concerns and safety considerations, it is crucial to handle this compound with care and adhere to appropriate safety protocols in laboratory environments.