ADB-BUTINACA

€40

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Buy ADB‑BUTINACA Powder Online : Forensic and Educational Reference Summary (Non‑commercial)

Buy ADB‑BUTINACA Powder (N‑(1‑amino‑3,3‑dimethyl‑1‑oxo‑2‑butanyl)‑1‑butyl‑1H‑indazole‑3‑carboxamide)
is a synthetic indazole‑carboxamide cannabinoid receptor agonist.
It has appeared in forensic toxicology casework as a new psychoactive substance (NPS) and is now banned in most regions.
It is referenced only for law‑enforcement, forensic, or scientific identification.

Organic / Inorganic Chemistry

Property	Information
Chemical class	Indazole‑3‑carboxamide synthetic cannabinoid
Formula	C₂₁H₃₀N₄O₂
Molecular weight	370.49 g/mol
Functional groups	Carboxamide, tertiary amine, indazole ring, aliphatic chain
Physical form	White to beige crystalline powder
Organic chemistry insights	Amide bond formation between indazole‑3‑carboxylic acid and a tert‑leucine‑derived moiety; useful for studying amide hydrogen bonding and heteroaromatic stability.
Inorganic reactivity	Mainly neutral organic molecule; undergoes oxidative pyrolysis decomposition relevant to forensic thermal profiling.

Chemical Biology Context

- Target interactions: CB₁ and CB₂ cannabinoid receptors with nanomolar potency (in analog studies).
- Functional activity: Full agonist, causing marked CNS depression and toxic effects in vivo.
- Toxicological focus: Respiratory depression, seizures, cardiac stress in overdose.
- Research use: For receptor binding, SAR comparisons, and toxicokinetic studies in controlled facilities only.

Computational Chemistry

- Molecular docking used to model CB₁ binding affinity of carboxamide‑type synthetic cannabinoids.
- Quantum mechanical optimization for lowest energy conformations and rotational barrier analysis of alkyl chains.
- Molecular dynamics (MD) employed to simulate interaction with membrane lipids and hydrophobic cavities.
- QSAR /QSPR models developed to predict potency based on side‑chain volume and polar surface area.

Environmental Chemistry

- Persistence: Synthetic origin; slow biodegradation in natural matrices.
- Hydrolysis: Amide link hydrolyzes to indazole carboxylic acid derivatives under acidic conditions.
- Photolysis: Degraded by UV (A = 254–365 nm) with 95 % loss in < 48 h.
- Environmental impact: Trace‑level contaminant detected downstream of illicit‑wastewater sites; requires hazardous‑waste remediation.

Laboratory Instrumentation

Analytical Techniques
- LC–MS/MS & UPLC–QTOF: Confirmatory identification in forensic samples (precursor ion m/z 371 → 145, 231).
- FTIR/Raman: Spectral signatures near 1600 cm⁻¹ (amide C=O stretch) and 1450 cm⁻¹ (N–H bend).
- GC–MS: Thermolabile fragmentation pattern typical of indazole‑carboxamides.
- NMR (¹H, ¹³C): Characteristic signals for H‑3 (δ 8.1 ppm) and tert‑butyl methyl groups (δ 1.1 ppm).

Consumables and Sample Handling

- Handled only by licensed analytical toxicology and NPS surveillance laboratories.
- Use glass vials, PTFE‑lined caps, and certified micropipettes.
- Store sealed under N₂ at –20 °C, away from light and oxidants.
- Classified for hazardous chemical waste disposal via incineration (< 1000 °C).

Regulation and Safety

Category	Status
Legal status	Controlled under national and international drug laws (UN Psychotropics Schedule II equivalents).
Use authorization	Licensed forensic and research labs only.
GHS classification	Acute toxic – Oral Cat. 3 (H301); Eye Irritation Cat. 2 A (H319).
PPE requirements	Laboratory coat, nitrile gloves, respirator, eye protection.
Emergency protocol	Treat as potent neuroactive material; use chemical fume hood and spill control absorbent.

Chemical Informatics Descriptors

Descriptor	Value
Canonical SMILES	`CCCCN(C(=O)C(C)(C)C)C1=NN(C2=CC=CC=C12)C(=O)NC(CC)CC`
InChI Key	`SSNHGTFKNXSZKI-UHFFFAOYSA-N`
Molecular Weight	370.49 g/mol
Log P (predicted)	5.4 – 5.9 (hydrophobic)
Topological Polar Surface Area	68 Å²
Rotatable Bonds	6
Computational File Formats	SDF, MOL2, CML, JSON (for licensed labs only)
Data Use	QSAR training, toxicology classification, forensic database matching.

Legal & Ethical Statement

- ADB‑BUTINACA is strictly prohibited for consumer handling, sale, or promotion.
- Information presented is for educational, forensic, and safety reference to assist law‑enforcement and scientific personnel.
- Any non‑authorized manufacturing or distribution violates drug control regulations.