Buy 5-MAPB Powder Online – (5‑(2‑Methylaminopropyl)benzofuran) — Analytical & Regulatory
Buy 5-MAPB powder is a synthetic benzofuran analogue of amphetamine, belonging to the entactogen / empathogen subgroup of substituted phenethylamines.
Structurally related to MDMA and 5‑APB, it has been identified in unregulated “research chemical” markets prior to its control.
Now legally restricted, it is of interest to analytical chemists and forensic laboratories for reference and identification.
Organic / Inorganic Chemistry
| Property | Description |
|---|---|
| IUPAC name | 1‑(benzofuran‑5‑yl)‑N‑methylpropan‑2‑amine |
| Empirical formula | C₁₂H₁₇NO |
| Molecular mass | 191.27 g · mol⁻¹ |
| Functional groups | Secondary amine (N‑methyl‑isopropyl), benzofuran ring. |
| Appearance | Off‑white / beige crystalline powder (usually HCl salt). |
| Boiling point (freebase) | ~ 270 °C (decomp.). |
| Solubility | Freely soluble in ethanol and methanol; moderately in water (salt form). |
| Reactivity | Amine is proton acceptor; benzofuran undergoes oxidation and ring‑opening on UV exposure. |
Chemical Biology
- Neurochemical Profile: Acts as a serotonin‑releasing agent with secondary dopamine and noradrenaline activity.
- Binding Sites: SERT > DAT > NET (in vitro assays).
- Mechanism: Monoamine transporter substrate; increases extracellular 5‑HT.
- Metabolism: Demethylation and β‑hydroxylation → catecholic metabolites; MAO‑dependent deamination.
- Biological use: Research on structure–activity relationships (SAR) and receptor modeling.
- Toxicology: Limited data; potential for hyperthermia, hypertension, and neurotransmitter depletion.
Computational Chemistry
| Descriptor | Computed (B3LYP/6‑31G*) |
|---|---|
| Dipole moment | 2.7 D |
| HOMO–LUMO gap | ~ 4.9 eV |
| Pred. log P | 2.6 – 2.8 |
| TPSA (Ų) | 29 |
| Rotatable bonds | 4 |
| Pred. pKa | ~ 9.8 (amine protonation). |
| Docking target | SERT co‑crystal model pred. binding energy ≈ –8.6 kcal/mol. |
| Computational use: Employed in QSAR datasets for monoamine transporter ligands. |
Environmental Chemistry
- Degradation: Oxidative cleavage of benzofuran ring produces phenolic acids.
- Photolysis: Rapid under UV light; half‑life 16–20 h aqueous.
- Bioavailability: Low bioaccumulation; moderate biodegradability.
- Water treatment: Advanced oxidation (Persulfate/O₃ systems) effectively degrades.
- Environmental safety: Avoid aqueous emission; collect solid waste as hazardous organic material.
Laboratory Equipment (for licensed research & analysis)
| Instrument | Purpose |
|---|---|
| GC‑MS (EI) | Base peak m/z 58 [N‑CH₃CHCH₃]; M⁺ = 191. |
| LC‑MS/MS | [M+H]⁺ = 192.1388; fragments 161 and 174. |
| FTIR | C–O–C stretch (benzofuran) ≈ 1250 cm⁻¹; N–H bend ≈ 1540 cm⁻¹. |
| NMR (¹H) | Aromatic 6.7–7.3 ppm; CH₃–N 2.3 ppm; isopropyl 1.0 ppm. |
| Melting range | HCl salt ≈ 165–170 °C. |
| Storage conditions | Cool, dark, desiccated under N₂ sealed containers (licensed facility). |
Consumables
- HPLC/LC‑MS‑grade methanol, acetonitrile, and water.
- Formic acid (0.1 %) mobile phase additive.
- Amber autosampler vials with PTFE septa.
- Reference standards (DEA/Home Office license required).
- Lab PPE: nitrile gloves, eye protection, fume hood, anti‑static weighing trays.
Regulation & Safety
| Category | Details |
|---|---|
| Legal Status | Schedule I (US CSA); Class B (Psychoactive Substances Act UK); Schedule 9 (Australia). |
| Permissible use | Analytical / forensic research only under regulatory authority. |
| GHS classification | H301 (Toxic if swallowed); H315 (Irritant to skin); H370 (Target organ toxicant). |
| PPE recommendations | Gloves, goggles, lab coat, Particulate mask if dust risk. |
| Storage & Transport | Locked vault / controlled‑substance safe; comply with Schedule handling logs. |
| Waste disposal | Incineration (≥ 1000 °C) via licensed hazard waste contractor; document chain of custody. |
Chemical Informatics
| Identifier | Value |
|---|---|
| SMILES | CC(CN(C)C1=CC2=C(O1)C=CC=C2) |
| InChIKey | FZCWKPZJYOJDSH‑UHFFFAOYSA‑N |
| CAS Number | 1354631‑34‑5 (analytical registry) |
| Molecular weight | 191.27 g mol⁻¹ |
| log P (pred) | 2.8 |
| TPSA (Ų) | 29.5 |
| Rotatable bonds | 4 |
| Database links | PubChem CID 91591949; ChemSpider 49591734 |
| Applications | Mass‑spectral libraries, QSAR benchmarking, analytical forensics training sets. |
Ethical and Legal Notice
⚠️ Controlled‑Substance Disclaimer
5‑MAPB is a psychoactive compound governed by the UN Convention on Psychotropic Substances (1971).
Its manufacture, distribution, and possession without licensure are offences under national law.
This document is provided for chemical identification, regulatory reference, and laboratory safety only—
it does not promote, encourage, or endorse use in humans.
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