Buy 4C-MAR Powder Online - (4‑Chloromethamphetamine) Powder — Analytical Reference Standard
Buy 4C-MAR Powder (4‑chloromethamphetamine) is a ring‑chlorinated phenethylamine derivative, part of the amphetamine chemical family.
It is examined in toxicological investigations and comparative SAR (structure–activity relationship) research to understand halogen effects on transporter affinity and metabolic fate.
Organic / Inorganic Chemistry
| Property | Specification |
|---|---|
| IUPAC Name | N‑methyl‑1‑(4‑chlorophenyl)propan‑2‑amine |
| Formula | C₁₀H₁₄ClN |
| Molecular Weight | 183.68 g · mol⁻¹ |
| Functional Groups | Secondary amine (N‑CH₃), para‑chloro‑substituted aryl ring, aliphatic hydrocarbon chain |
| Physical Form | Crystalline powder (often HCl salt in research grade) |
| Melting Point (HCl salt) | ≈ 172–174 °C |
| Solubility | Polar organic solvents (EtOH, MeOH); limited aqueous solubility. |
| Chemical Stability | Stable under dry neutral storage conditions; avoid UV and moisture. |
Chemical Biology
- Classification: Substituted amphetamine analog with psychostimulant properties.
- Mechanism: Monoamine transporter substrate — stimulates dopamine (DA) and norepinephrine (NE) release.
- SAR Insight: Chloro‑substitution increases lipophilicity and extends half‑life relative to methamphetamine.
- Metabolism: N‑demethylation → 4‑chloramphetamine; oxidative deamination by MAO → 4‑chlorophenyl‑acetone intermediate; further oxidation to benzoic acids.
- In vitro use: Standard for mass‑spectral method validation and forensic toxicology training.
- Safety note: Neurotoxic to serotonergic and dopaminergic cells in biological systems — for research use only.
Computational Chemistry
| Parameter | B3LYP/6‑31G* Prediction |
|---|---|
| Dipole Moment | 2.7 Debye |
| HOMO–LUMO Gap | ≈ 5.1 eV |
| Predicted log P | 2.75 – 2.9 |
| pKa (amine) | 9.6 |
| TPSA | 27 Ų |
| Rotatable Bonds | 3 |
| Docking energy (hDAT) | ≈ –8.8 kcal · mol⁻¹ |
| Insights: Chlorine atom improves membrane partitioning and moderately enhances dopamine transporter affinity over non‑halogenated analogues. |
Environmental Chemistry
- Hydrolysis: Minimal under neutral conditions.
- Photolysis: Degrades slowly under UV, producing 4‑chlorobenzaldehyde and amine residues.
- Soil Mobility: Low (volatility) and moderate organic sorption.
- Biodegradability: Limited; potential persistence in aquatic sediments.
- Waste Handling: Treat as hazardous organic compound — incineration at > 1100 °C.
- Hazard: Persistent organic pollutant potential under improper disposal.
Laboratory Equipment
| Equipment | Analytical Role |
|---|---|
| GC‑MS (EI) | M⁺ = 183 m/z (Cl isotopic pair 183/185), base fragment at 44 m/z (CH₂NHCH₃). |
| LC‑MS/MS | [M+H]⁺ = 184.103 m/z; fragment ion = 44 m/z (N‑methyl amine fragment). |
| FTIR | 3360 cm⁻¹ (N–H stretch), 1490 cm⁻¹ C–Cl, 1250 cm⁻¹ C–N. |
| ¹H NMR (400 MHz) | δ 7.2 (Ar H), 2.9 (CH₂), 2.3 (N‑CH₃), 1.3 (CH₃). |
| Storage Requirements | Dry, dark, ≤ –20 °C, airtight amber container with desiccant. |
Consumables
- Analytical‑grade solvents (Acetonitrile, Methanol, Water 18.2 MΩ cm).
- PTFE membrane filters (0.22 µm).
- Certified HPLC vials (amber).
- Calibrated pipettes and microsyringes.
- Personal Protective Equipment (PPE): chemical nitrile gloves, lab coat, respiratory protection when powder handling.
Regulation & Safety
| Category | Specification |
|---|---|
| Legal Status | Schedule I controlled substance (USA Analogue Act); Class A (UK Misuse of Drugs Act); controlled in EU, CA, AU. |
| Permitted Use | For analytical, toxicological, or academic research within licensed institutes only. |
| GHS Hazard Statements | H301 – Toxic if swallowed; H331 – Toxic if inhaled; H370 – Causes organ damage. |
| Hazard Pictograms | ☠️ ⚠️ 🌡️ |
| Precautions | Use fume hood; avoid direct contact; secure storage in controlled substance safe. |
| Spill Response | Cover with activated carbon, wipe with 70% ethanol, dispose as toxic waste. |
| Waste Disposal | Licensed hazard waste contractor — thermal destruction. |
| Emergency | Accidental exposure → seek medical help immediately; symptoms include tachycardia and hypertension. |
Chemical Informatics
| Identifier | Details |
|---|---|
| SMILES | CC(CC1=CC=C(Cl)C=C1)NC |
| InChIKey | MHJWUEJZXYEGDQ‑UHFFFAOYSA‑N |
| CAS Number | 5581‑96‑8 (related 4‑chloramphetamine listing) |
| Formula Weight | 183.68 g · mol⁻¹ |
| TPSA | 27 Ų |
| Predicted log P | 2.8 |
| Rotatable Bonds | 3 |
| Use in informatics | QSAR/QSPR training, MS reference databases, controlled substance screening libraries. |
Regulatory & Ethical Notice
⚠️ Controlled Substance Disclaimer
4C‑MAR (4‑chloromethamphetamine) is classified as a prohibited stimulant under international drug‑control laws.
Its manufacture, possession, or distribution without authorization is illegal.
This information exists solely for scientific documentation, regulatory compliance, and educational reference.
No portion of this text constitutes a recommendation or promotion for use in humans or commerce.
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