Buy 3‑Me‑PCP Powder Online — Analytical Reference Standard
Buy 3‑Me‑PCP powder (3‑methyl‑1‑[1‑(phenylcyclohexyl)] piperidine) is a phencyclidine (PCP)‑class dissociative.
It is investigated in forensic chemistry, analytical method development, and comparative pharmacology within the arylcyclohexylamine series.
Organic / Inorganic Chemistry
| Property | Information |
|---|---|
| IUPAC Name | 1‑[1‑(3‑methylphenyl)cyclohexyl]piperidine |
| Molecular Formula | C₁₈H₂₇N |
| Molecular Weight | 257.42 g · mol⁻¹ |
| Chemical Class | Arylcyclohexylamine / Dissociative amine |
| Functional Groups | Secondary amine, aromatic ring, cycloalkane |
| Physical Form | White to off‑white crystalline powder (HCl salt) |
| Melting Point (HCl) | ≈ 232 – 235 °C |
| Solubility | Slightly soluble in water; freely soluble in alcohol and chloroform. |
| Stability | Stable when dry and protected from UV light; amine may oxidize over time. |
Chemical Biology
- Mechanistic Class: NMDA receptor antagonist (arylcyclohexylamine family).
- Research Purpose: Used as a forensic reference standard to compare mass spectral and chromatographic profiles with PCP and its analogs.
- In vitro Metabolism: Hydroxylation and N‑oxidation yield piperidine‑oxide and phenolic metabolites.
- SAR (Structure–Activity): The 3‑methyl substitution on the phenyl ring increases lipophilicity, altering binding at NMDA and sigma‑1 receptors compared to PCP.
Computational Chemistry
| Descriptor | Predicted Value (B3LYP/6‑31G*) |
|---|---|
| Dipole Moment | 2.74 D |
| HOMO–LUMO Gap | 6.1 eV |
| log P (pred.) | 4.8 |
| pKa (amine) | 10.2 |
| TPSA (Ų) | 24 |
| Rotatable Bonds | 4 |
| Docking Energy (NMDA receptor) | ≈ –9.5 kcal · mol⁻¹ |
| Notes: Rigid cyclohexyl scaffold positions the amine for optimal hydrogen bonding with GluN1 subunit, similar to PCP but with slightly enhanced hydrophobic interactions. |
Environmental Chemistry
- Hydrolysis: Relatively resistant; amine hydrolysis low under neutral conditions.
- Photolysis: Degrades via oxidative dimerization and aromatic ring opening under UV light.
- Biodegradability: Moderate; amine oxidation to nitrone/oxide derivatives has been observed.
- Bioaccumulation: Moderate potential (log Kow ~ 4.8).
- Waste Treatment: Controlled high‑temperature destruction (> 1100 °C) or chemical oxidation with neutralization.
Laboratory Equipment
| Instrument | Purpose |
|---|---|
| GC–MS (EI) | M⁺ = 257 m/z; principal fragments 86 (piperidyl), 200 (aromatic core). |
| LC–MS/MS | [M+H]⁺ = 258 m/z; major fragment → 200 m/z. |
| FTIR (ATR) | C–N stretch ≈ 1130 cm⁻¹; N–H stretch ≈ 3340 cm⁻¹; aryl C–H ≈ 3030 cm⁻¹. |
| ¹H NMR (400 MHz; CDCl₃) | δ 7.1 (Ar H), 2.8 – 3.0 (NCH₂), 1.5 – 2.1 (cyclohexyl protons). |
| Storage | Dry, dark, below –20 °C in inert atmosphere sealed amber bottle. |
Consumables
- LC–MS grade methanol and acetonitrile.
- Formic acid (0.1 %) for HPLC buffer preparation.
- Amber autosampler vials and PTFE/silicone septa.
- Nitrile gloves, chemical splash goggles, and FFP2 respirators.
- Desiccant packets and argon flush for long‑term storage.
Regulation & Safety
| Aspect | Information |
|---|---|
| Controlled Status | Schedule I (US DEA), Class A (UK MDA 1971), Schedule 9 (Australia); banned under EU psychoactive substance regulation. |
| Authorized Use | Licensed forensic and toxicological analysis only. |
| GHS Signal Word | Danger |
| Hazard Statements | H301: Toxic if swallowed • H331: Toxic if inhaled • H311: Toxic in contact with skin. |
| Precautions | Use fume hood and appropriate PPE; avoid dust formation; ensure secure storage. |
| Spill Response | Absorb with inert material, seal for hazardous waste disposal. |
| Disposal | By licensed incineration (> 1100 °C) or approved chemical neutralization. |
Chemical Informatics
| Field | Data |
|---|---|
| SMILES | CC1=CC=CC(C2(CCCCC2)N3CCCCC3)=C1 |
| InChIKey | MOGMNKUNAWQAQK‑UHFFFAOYSA‑N |
| Molecular Weight | 257.42 g · mol⁻¹ |
| TPSA | 24 Ų |
| log P | 4.8 |
| Rotatable Bonds | 4 |
| CAS Number | 1246816‑63‑2 |
| Applications | Forensic identification reference material, NPS spectrum libraries, QSAR datasets. |
Legal & Ethical Notice
⚠️ Controlled‑Substance Compliance Statement
3‑Methylphencyclidine (3‑Me‑PCP) is a regulated dissociative substance under international drug control treaties.
Handling or analysis requires appropriate authorization, secure storage, and traceable record‑keeping.
This profile serves only as scientific and regulatory reference material and not as an endorsement or promotion of the substance.
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