Buy 3‑FMC Powder Online — Analytical Reference Material
Buy 3‑FMC powder is a fluorinated synthetic cathinone, structurally related to methcathinone and 3‑MMC.
It belongs to the β‑keto‑phenethylamine class.
As a forensic and reference compound, it aids in spectral library development for fluorinated cathinone analogs.
Organic / Inorganic Chemistry
| Property | Information |
|---|---|
| IUPAC Name | 1‑(3‑fluorophenyl)‑2‑methylamino‑1‑propan‑1‑one |
| Molecular Formula | C₁₀H₁₂FNO |
| Molecular Weight | 181.21 g mol⁻¹ |
| Chemical Family | Synthetic cathinones (β‑keto amphetamines) |
| Functional Groups | Aromatic fluoro substituent, secondary amine, carbonyl (ketone) |
| Physical Form | White to off‑white crystalline powder (often as hydrochloride salt) |
| Solubility | Soluble in methanol and acetonitrile; moderately soluble in water |
| Melting Point (HCl) | ≈ 172 – 176 °C |
| Boiling Point (free base) | ≈ 270 °C (decomposes) |
| Chemical Stability | Stable under ambient conditions if dry and light‑protected. |
Chemical Biology
- Pharmacological Class: Monoamine transporter substrate (stimulant prototype).
- Research Applications: Forensic toxicology calibration; structure–activity relationship (SAR) investigations on β‑keto phenethylamines.
- Metabolism (in vitro): N‑demethylation, reduction of the keto group to alcohol, and fluorinated ring hydroxylation.
- SAR Discussion: Para/Meta fluorination modulates dopamine transporter affinity and increases lipophilicity compared to unsubstituted methcathinone.
Computational Chemistry
| Parameter | Predicted Value (B3LYP/6‑31G*) |
|---|---|
| Dipole Moment | 2.84 D |
| HOMO–LUMO Gap | 6.0 eV |
| log P (pred.) | 1.9 |
| pKa (amine) | 9.85 |
| TPSA (Ų) | 32 |
| Rotatable Bonds | 3 |
| Docking (E₍DAT₎) | ≈ –8.4 kcal mol⁻¹ |
| Interpretation: Fluorine enhances π‑stacking and slightly stabilizes interaction with dopamine transporter binding site. |
Environmental Chemistry
- Hydrolysis: Resistant at neutral pH; amine oxidation dominant degradation pathway.
- Photolysis: Aromatic fluoro ring confers moderate UV stability.
- Biodegradability: Slow under aerobic conditions; more rapid under oxidative treatment (Fenton process).
- Bioaccumulation Potential: Moderate (log Kow ~ 1.9).
- Waste Disposal: Controlled destruction via high‑temperature incineration or approved oxidative neutralization.
Laboratory Equipment
| Instrument | Analytical Application |
|---|---|
| LC–MS/MS | [M+H]⁺ = 182 m/z; main fragments ≈ 164, 105 m/z. |
| GC–MS (EI) | M⁺ = 181 m/z; fragments 58 (amine), 105 (aromatic fluoro fragment). |
| FTIR (ATR) | C=O ≈ 1690 cm⁻¹ |
| ¹H NMR (400 MHz) | δ 7.1–7.4 (Ar H), 3.4 (CH–NH), 1.2–1.5 (CH₃). |
| Storage | –20 °C in sealed amber vial under dry atmosphere. |
Consumables
- LC-grade methanol, acetonitrile, and formic acid solutions.
- Analytical autosampler vials (amber glass, PTFE/silicone septa).
- High‑precision balances (≥ 0.1 mg accuracy).
- Certified reference standards for internal calibration.
- PPE: nitrile gloves, face shield, lab‑coat.
Regulation & Safety
| Aspect | Information |
|---|---|
| Controlled Status | Listed under Schedule I (USA DEA) • Class B (UK MDA 1971) • Schedule 9 (Australia). |
| Authorized Use | Laboratory use only under appropriate licenses. |
| GHS Signal Word | Danger |
| Hazard Statements | H301: Toxic if swallowed • H331: Toxic if inhaled • H311: Toxic on skin contact. |
| Precautionary Measures | Handle in fume hood; avoid dust and aerosol formation. |
| First Aid | Rinse exposed area with water ≥ 15 min; seek medical support immediately. |
| Waste Procedure | Dispose via licensed hazardous chemical incinerator. |
Chemical Informatics
| Field | Data |
|---|---|
| SMILES | CC(C(=O)C1=CC(=CC=C1)F)NC |
| InChIKey | MERJFIZOGFLWDW‑UHFFFAOYSA‑N |
| Molecular Weight | 181.21 g mol⁻¹ |
| TPSA | 32 Ų |
| log P | 1.9 |
| Rotatable Bonds | 3 |
| CAS Number | 1082119‑33‑1 |
| Applications | Analytical reference standard for forensic screening, SAR training datasets. |
Legal & Ethical Notice
⚠️ Controlled‑Substance Statement
3‑Fluoromethcathinone (3‑FMC) is classified as a psychoactive stimulant under controlled‑substance legislation in many countries.
Handling and use must comply with national and international regulations.
The data given below are for forensic and scientific uses only and not for promotion or sale to the public.
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