Buy 3‑FMA Pellets 50mg Online — Analytical Reference Material
3‑Fluoromethamphetamine (Buy 3‑FMA Pellets 50mg) is a fluorinated amphetamine derivative, belonging to the phenethylamine stimulant family.
It’s primarily used as a calibration standard in forensic toxicology and analytical chemistry to identify fluorinated amphetamine isomers by spectroscopic or MS methods.
Pellet preparation (e.g., 50 mg compressed units) supports mass consistency and ease of handling in controlled research protocols.
Organic / Inorganic Chemistry
| Property | Information |
|---|---|
| IUPAC Name | 1‑(3‑fluorophenyl)‑N‑methylpropan‑2‑amine |
| Molecular Formula | C₁₀H₁₄FN |
| Molecular Weight | 167.22 g mol⁻¹ |
| Chemical Class | Fluoro‑substituted amphetamine |
| Functional Groups | Secondary amine, aromatic fluoro, alkyl chain |
| Appearance | White/off‑white solid pellets pressed to 50 mg ± 2 % |
| Solubility | Freely soluble in methanol and acetonitrile; limited solubility in water. |
| Boiling Point | ≈ 203 – 205 °C (free base decomposes). |
| Melting Point (HCl) | ≈ 159 – 163 °C |
| Stability | Stable at ambient temperature if dry and protected from light. |
Chemical Biology
- Research Class: Monoamine releasing agent (amphetamine‑type).
- Applications: Used for LC–MS/MS method validation of fluorinated amphetamine metabolites.
- In Vitro Activity Profiles: Partial dopamine/norepinephrine transporter substrate; serotonin activity moderate—data for cell culture only.
- Metabolism (in vitro): N‑dealkylation, β‑hydroxylation, para/ortho oxidation on fluorophenyl ring, formation of oxime derivatives.
- Biological Stability: Resistant to oxidative hydroxylation due to fluoro substitution.
Computational Chemistry
| Descriptor | Predicted Value (B3LYP/6‑31G*) |
|---|---|
| Dipole Moment | 2.73 D |
| HOMO–LUMO Gap | 6.2 eV |
| log P (pred.) | 2.7 |
| pKa (amine) | 9.8 |
| TPSA (Ų) | 26 |
| Rotatable Bonds | 3 |
| Docking (E₍DAT₎) | ~ –8.2 kcal mol⁻¹ |
| Interpretation: 3‑fluorine substitution shifts electron density and lipophilicity, altering monoamine transporter affinity vs. methamphetamine. |
Environmental Chemistry
- Hydrolysis: Stable under neutral aqueous conditions.
- Photodegradation: Moderate rate under UV exposure (λ < 300 nm).
- Biodegradation: Slow to moderate; fluoroaromatic residues resist microbial oxidation.
- Bioaccumulation Potential: Moderate (log Kow ≈ 2.7).
- Disposal Method: Oxidative destruction (e.g., KMnO₄ oxidation) or incineration > 1100 °C in licensed facility.
Laboratory Equipment
| Instrument | Analytical Use |
|---|---|
| LC–MS/MS | [M+H]⁺ = 168 m/z; fragments: 150 m/z (loss H₂O), 119 m/z (benzyl fragment). |
| GC–MS (EI) | M⁺ = 167 m/z; base peak 44 (methylamine fragment). |
| FTIR (ATR) | C–N stretch ≈ 1140 cm⁻¹ • C–F ≈ 1220 cm⁻¹ • N–H ≈ 3300 cm⁻¹ |
| ¹H NMR (400 MHz) | δ 7.0–7.4 (aromatic H), 2.8–3.1 (CH–NH protons). |
| Pellet Verification | Weight uniformity ± 0.5 mg by microbalance. |
| Storage | –20 °C dry, light‑protected polymer tube under nitrogen atmosphere. |
Consumables
- LC‑grade solvents (methanol, acetonitrile, formic acid 0.1 % aq.).
- Amber HPLC/GC vials with PTFE/silicone septa.
- Analytical micro spatulas, anti‑static polymer tweezers, weighing boats.
- PPE — gloves, lab coat, protective eyewear, and fume‑hood operation.
Regulation & Safety
| Aspect | Information |
|---|---|
| Controlled Status | Schedule I (US Analogue Act coverage); Class B (UK MDA 1971); Schedule 9 (Australia). |
| Laboratory Use | Authorized analytical and toxicological investigation only under license. |
| GHS Signal Word | Danger |
| Hazard Phrases | H301: Toxic if swallowed • H311: Toxic in contact with skin • H331: Toxic if inhaled. |
| Precautionary Measures | Operate in ventilated fume hood; wear PPE and observe dust control. |
| First Aid | Flush exposure areas ≥ 15 minutes; seek medical attention. |
| Waste Disposal | Send sealed residues to permitted hazardous waste destruction facility. |
Chemical Informatics
| Field | Data |
|---|---|
| SMILES | CC(CC1=CC(=CC=C1)F)NC |
| InChIKey | CRYQINOUSPVWLC‑UHFFFAOYSA‑N |
| Formula Weight | 167.22 g mol⁻¹ |
| TPSA | 26 Ų |
| log P | 2.7 |
| Rotatable Bonds | 3 |
| CAS Number | 1537‑49‑9 |
| Applications | Reference standard for forensic MS libraries and SAR/QSAR data training. |
Legal & Ethical Notice
⚠️ Controlled‑Substance Compliance Statement
3‑Fluoromethamphetamine (3‑FMA) is controlled under stimulant regulations in many countries. All handling must comply with national and international law.
This documentation is for scientific reference only and must not be used for marketing or promotional purposes.
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