Buy 2F‑Ketamine Crystalline Powder Online

2F-Ketamine Crystal powder

€10

Prices is per 0.5 gram

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Buy 2F‑Ketamine Crystalline Powder Online — Analytical Reference Substance

Buy 2f‑ketamine crystalline powder (2‑fluorodeschloroketamine, 2‑FDCK) is a fluorinated analogue of ketamine, belonging to the arylcyclohexylamine family.
It is used exclusively as a calibration reference and instrumental standard in controlled arylcyclohexylamine analysis by forensic and environmental chemistry laboratories.

The crystalline powder form ensures high purity and consistent calibration for LC–MS/MS, GC–MS, and NMR spectroscopy.

Organic / Inorganic Chemistry

Property	Details
IUPAC Name	2‑(2‑fluorophenyl)‑2‑(methylamino)cyclohexan‑1‑one
Molecular Formula	C₁₃H₁₆FNO
Molecular Weight	221.27 g mol⁻¹
Functional Groups	β‑ketone (C=O), secondary amine, aryl fluoride
Chemical Classification	Organic compound – Cyclohexanone derivative
Appearance	Off‑white microcrystalline powder
Melting Point (HCl salt)	≈ 184 – 186 °C
Boiling Point (free base)	> 340 °C (decomp.)
Solubility	Freely soluble in ethanol and acetonitrile; sparingly soluble in water (< 10 mg mL⁻¹)
pKa (amine)	≈ 8.45
log P (pred.)	≈ 3.1
Purity Range	≥ 98 % (by HPLC)

Chemical Biology

Pharmacological class: Arylcyclohexylamine NMDA receptor antagonist analog used in binding‑site model studies.
Research Application: Referenced for spectral comparison and metabolic simulation of arylcyclohexylamines.
Enzymatic Interactions: Target CYP2B6, CYP2D6, and CYP3A4 in vitro microsomal conversions → 2F‑norketamine metabolite.
Structural Characteristic: Fluoro substitution reduces hydrogen‑bond acceptor density and alters lipophilicity versus ketamine.
Use Restriction: Not evaluated for therapeutic or clinical applications.

Computational Chemistry

Parameter	Value (B3LYP/6‑31G*)
Dipole Moment	3.42 Debye
HOMO–LUMO Gap	5.75 eV
Topological Polar Surface Area (TPSA)**	29 Å²
Rotatable Bonds	2
Binding Energy (NMDA receptor model)**	–9.1 kcal·mol⁻¹
LogP (pred.)	3.1
Optimized Ring Torsion	12.7° due to ortho‑F steric effect
Interpretation	Fluorine increases electron density on aromatic ring and modifies dipole moment, affecting membrane permeability prediction.

Environmental Chemistry

Persistence: Moderate due to C–F bond stability.
Photostability: Partial UV degradation (half‑life ≈ 6 h at 280 nm).
Hydrolysis: Stable pH 4–8; slow oxidative decomposition in alkaline media.
Partition Coefficient (log Kow): ≈ 3.0 → medium bioaccumulation potential.
Biodegradability: Limited; requires chemical oxidative destruction before disposal.
Environmental Treatment: Advanced oxidation (e.g., Fenton process, KMnO₄), then authorized high‑temperature incineration (≥ 1100 °C).

Laboratory Equipment

Equipment	Purpose
LC–MS/MS (ESI⁺)	[M+H]⁺ = 222 m/z → fragments 204 and 186; quantitative calibration.
GC–MS (EI)	Parent ion = 221 m/z; base peak = 179 m/z.
FTIR (ATR)	C=O stretch ≈ 1680 cm⁻¹; C–F stretch ≈ 1225 cm⁻¹.
¹H NMR (CDCl₃)	δ 7.0–7.3 ppm (aromatic H) · δ 2.8–3.0 (N‑CH₃).
HPLC Q‑Control	C18 column; MeOH/H₂O (70:30 + 0.1% formic acid); Rt ≈ 4.4 min.
Storage	≤ –20 °C; desiccated; protected from light and air exposure.

Laboratory Consumables

Analytical balance (accuracy ±0.01 mg).
LC–MS grade methanol and acetonitrile.
Certified reference standards (Ketamine and Deschloroketamine comparators).
Amber storage vials with PTFE‑lined seals.
PPE: nitrile gloves, safety goggles, lab coat, P3 respirator.

Regulation & Safety

Category	Information
Legal Status	Class B (UK MDA 1971); Schedule I Analogue (US); Schedule 9 (Australia).
Authorized Use	Forensic and analytical research under license only.
UN Classification	UN 2811 · Toxic solid, organic, n.o.s.
GHS Signal Word	Danger
Hazard Codes	H301 · H311 · H331 · H370 — Toxic if swallowed, inhaled, or through skin; may cause organ damage.
Precautions	Avoid dust generation; conduct work in fume hood; label and segregate storage.
Disposal	Collect sealed waste containers; certified incineration facility required.
First Aid	Flush affected area ≥ 15 min; seek immediate medical assistance.

Chemical Informatics

Descriptor	Value
SMILES	`CN(C1(CCCCC1)C(=O)C2=CC=CC=C2F)`
InChIKey	`LQKQZQVISTWWTH‑UHFFFAOYSA‑N`
Molecular Mass	221.27 g mol⁻¹
TPSA	29 Å²
log P	3.1
Rotatable Bonds	2
CAS RN (reference)	[Not officially designated in CAS open registry]
Relevance	Used in QSAR, mass‑fragmentation, and computational toxicology databases.

Legal & Ethical Statement

⚠️ Controlled‑Substance Notice
2F‑Ketamine (2‑FDCK) is subject to national and international drug control regulations. Any use outside licensed research is illegal. This document is intended for educational, regulatory, and forensic reference only — not promotion, advertising, or distribution purposes.