GW-0742 Capsules

Buy GW-0742 Capsules Online

Buy GW-0742, also known as GW0742, is a potent and highly selective agonist of peroxisome proliferator-activated receptor delta (PPARδ). It is utilized in research settings to investigate its effects on lipid metabolism, neuroprotection, and cardiovascular health. GW-0742 is available in capsule form for research purposes.

Chemical Composition and Properties

• Chemical Name: 2-[4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]-acetic acid
• Molecular Formula: C₂₁H₁₇F₄NO₃S₂
• Molecular Weight: 471.49 g/mol
• CAS Number: 317318-84-6
• Chemical Structure: GW-0742 features a thiazolylmethylthio group attached to a fluorinated phenyl ring, contributing to its high affinity and selectivity for PPARδ receptors.

Organic and Inorganic Chemistry

The synthesis of GW-0742 involves complex organic reactions, including the formation of thiazole and phenoxyacetic acid moieties. Precise control over reaction conditions is essential to ensure the purity and efficacy of the final product.

Chemical Biology

In chemical biology, GW-0742 serves as a valuable tool for studying the role of PPARδ in regulating lipid metabolism, inflammation, and energy homeostasis. By activating PPARδ, GW-0742 has been shown to increase fatty acid oxidation and protect against ischemia/reperfusion injury in cardiomyocytes.

Computational Chemistry

Computational chemistry techniques, such as molecular docking and dynamic simulations, are employed to model the interaction between GW-0742 and PPARδ receptors. These studies help elucidate binding affinities and conformational changes induced by the compound, aiding in the design of more effective PPARδ agonists.

Environmental Chemistry

While GW-0742 is primarily used in controlled laboratory environments, it is essential to consider its environmental impact. Proper disposal methods should be followed to prevent any potential contamination, adhering to environmental safety guidelines.

Laboratory Equipment and Consumables

Handling GW-0742 requires standard laboratory equipment, including precision balances, glassware, and personal protective equipment (PPE) to ensure safe and accurate experimentation. Consumables such as solvents and reagents used in the synthesis and analysis of GW-0742 should be of high purity to maintain experimental integrity.

Regulation and Safety

As a research chemical, GW-0742 is subject to regulations governing the use of experimental compounds. Researchers must comply with institutional and governmental guidelines, including obtaining necessary approvals and ensuring proper documentation. Safety data sheets (SDS) should be reviewed to understand the hazards associated with GW-0742, and appropriate safety measures must be implemented during its handling and disposal.

Hazard Statements:

• GW-0742: Harmful if swallowed. Causes skin irritation. Causes serious eye irritation.

In case of contact with eyes, rinse gently with water for several minutes. If contact lenses are present and easy to remove, do so. For skin contact, wash thoroughly with soap and water. In the event of inhalation, move the affected person to fresh air and ensure easy breathing.

Chemical Informatics

Chemical informatics databases provide comprehensive information on GW-0742, including its chemical properties, biological activities, and synthesis protocols. Utilizing these resources facilitates efficient research planning and data analysis, contributing to the advancement of knowledge in the field.

In summary, GW-0742 capsules are utilized in research to explore the compound’s effects on PPARδ activation and its potential applications in metabolic and cardiovascular health. Due to regulatory concerns and potential safety issues, it is crucial to handle this compound with appropriate precautions and in compliance with all relevant regulations.