Buy 6‑APB Powder Online – (6‑(2‑Aminopropyl)benzofuran) — Scientific & Regulatory Reference
Buy 6‑APB Powder is a benzofuran derivative with a structural core resembling MDMA but incorporating a fused oxygen heterocycle.
It first appeared in analytical and toxicology casework as a novel psychoactive substance (NPS) in the early 2010s.
It has no lawful medicinal or consumer use and is Schedule I/Class A in most countries.
Organic / Inorganic Chemistry
| Property | Description |
|---|---|
| IUPAC name | 1‑(benzofuran‑6‑yl)‑propan‑2‑amine |
| Molecular formula | C₁₁H₁₃NO |
| Molar mass | 175.23 g · mol⁻¹ |
| Functional groups | Aromatic furan oxygen, secondary amine (–NH–), alkyl chain |
| Physical form | Crystalline powder (off‑white to tan); HCl salt is hygroscopic |
| Reactivity | Forms hydrochloride and oxalate salts; oxidizes to quinone/furanone products; amine acetylation possible. |
Chemical Biology
- Pharmacodynamics: Indirect monoamine‑releasing agent acting primarily on 5‑HT, DA, and NE transporters (by analogy with MDMA).
- Toxicological interest: Studied in forensic and clinical settings for acute sympathomimetic overdose profiles.
- Biotransformation: Primary hepatic metabolites include O‑desmethyl‑6‑APB and hydroxybenzofuran derivatives.
- Scientific use: Analytical standard in LC–MS and NMR libraries for law‑enforcement toxicology.
Computational Chemistry
| Parameter | Computational Observation |
|---|---|
| Geometry optimization | B3LYP / 6‑31G* predicts planar benzofuran with amine side‑chain dihedral ≈ 65° (sterically favored). |
| HOMO–LUMO gap | 4.3 eV (DFT prediction) — moderate stability. |
| Dipole moment | ≈ 2.1 D for neutral form. |
| Docking models | Used in computational studies of monoamine transporter binding as part of SAR series; not experimental bioassay. |
| QSAR features | A log P = 2.5; TPSA = 32 Ų; H‑bond acceptors = 2; donors = 1. |
Environmental Chemistry
- Persistence: Moderate; aromatic ring resistant to microbial cleavage.
- Degradation: Oxidation → carboxybenzofuran and quinone products.
- Photolysis: UV exposure reduces amine and ring integrity; half‑life ≈ 48 h in surface water.
- Waste category: Organic hazard (UN 2811 – Toxic solid, organic, n.o.s.).
- Treatment: High‑temperature incineration or advanced oxidation (H₂O₂ / UV).
Laboratory Equipment (Licensed Forensic Facilities)
| Technique | Application |
|---|---|
| LC–MS/MS (QqQ) | Quantitation in blood, urine, or powder extracts; MRM transitions e.g., m/z 176 → 159 → 131. |
| GC–MS | Characteristic fragment ions m/z 44, 77, 105 (benzofuran core). |
| FTIR / Raman | Diagnostic bands: νC–O 1260 cm⁻¹, νN–H 3400 cm⁻¹, aromatic C=C 1600 cm⁻¹. |
| NMR (¹H, ¹³C) | Confirms benzofuran substitution pattern and amine side‑chain connectivity. |
| UV‑Vis | λₘₐₓ ≈ 275 nm (π→π*). |
Required laboratory controls
- Class II fume hood or negative‑pressure glovebox
- 0.1 mg precision balance
- Hazardous organic waste segregation
Consumables and Sample Handling
- Amber autosampler vials, PTFE caps.
- HPLC‑grade methanol / acetonitrile.
- PTFE 0.22 µm filters.
- Certified reference weights and pipettes.
- Sample solvent normally acidified (0.1 % formic acid) to stabilize amine salt.
Regulation & Safety
| Category | Information |
|---|---|
| Controlled status | Schedule I (USA DEA); Class B → Class A (EU/UK Misuse of Drugs Act); listed on UN NPS database. |
| Authorized use | Forensic, toxicology, and law‑enforcement research only. |
| GHS classification | Acute Toxicity Cat. 3 (H301/H331); STOT (SE) Cat. 1 (H370). |
| PPE | Lab coat, nitrile gloves, respirator (P3 filter), goggles. |
| Storage | –20 °C, desiccated, in locked controlled substance cabinet. |
Chemical Informatics
| Descriptor | Value |
|---|---|
| SMILES | CC(N)CC1=CC2=C(O1)C=CC=C2 |
| InChI Key | QWUWCCQZLGKZHM‑UHFFFAOYSA‑N |
| Molecular Weight | 175.23 g /mol |
| Log P | 2.48 (pred.) |
| TPSA | 32.3 Ų |
| Rotatable bonds | 2 |
| FAIR data uses | Spectral indexing, AI‑toxicology datasets, and cross‑reference in forensic chemical registries. |
Legal and Ethical Notice
⚠️ Strict Compliance Reminder:
6‑APB is a controlled entactogen with no recognized safe or legal human use.
Information above serves educational, forensic, and regulatory documentation only.
Possession, manufacture, or sale without a license is a criminal offense.
Laboratories must adhere to national drug control laws, ISO 17025 standards, and GLP practice.
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